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The origin of sensory innernation of the peritoneum in the rat

Research Project

Project/Area Number 12670006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionHYOGO COLLEGE OF MEDICINE

Principal Investigator

TANAKA Koichi  Hyogo College of Medicine, Associate Professor, 医学部, 講師 (20125941)

Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
KeywordsPeritoneum / Sensory innervation / Dorsal Root Ganglion / Nodose ganglion / Automic nervous system / Rat / Neuronal tracer
Research Abstract

The distribution of sensory neurons innervating the peritoneum was studied using axonal transport of fluoro-gold. The tracer was injected to parietal peritoneum, diaphragm, mesentery, mesocolon, visceral peritoneum covering the stomach, small intestine, and colon. After ten days of survival period bilateral dorsal root ganglia from C2 to S6, and the nodose ganglia were dissected. The cryostat sections of these ganglia were mounted on glass slides and observed with a fluorescence microscope. In cases where the tracer was placed on the peritoneum covering the abdominal wall, labeled neurons were observed only in the ipsilateral dorsal root ganglia. A small number of neurons in nodose and cervical dorsal root ganglia of both sides were labeled after placing the tracer on the central part of diaphragm.When fluoro-gold was applied to the peripheral part of the diaphragm, nodose ganglion was negative, and dorsal root ganglia from T6 to T12 were positive. Many neurons in the nodose ganglia in addition to somata in the dorsal root ganglia from T4 to T13 were labeled when the tracer was placed on the peritoneum lining the stomach, small intestine or caecum. Labeled neurons were observed in the nodose and dorsal root ganglia from T13 to L2 and L5 to S1 after applying the tracer on to the colon. Ganglion cells in the nodose and dorsal root ganglia from T5 to T13 were positive when fluoro-gold was placed on the mesentery. These results suggest that most of the parietal peritoneum receives sensory nerves from dorsal root ganglia and the visceral peritoneum from both spinal nerves and the vagus nerve.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 田中宏一, 千葉胤道: "ラット腹膜の知覚神経の起始"解剖誌. 75. 128-128 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Tanaka, T.Matsugami, T.Chiba: "The sensory inner vation of peritoneum"Autonomic Neuroscience : Basic and Clinical. 82. 49-50 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koichi Tanaka, et al.: "The intrinsic origin of NOS-iv nerve fibers in the right atrium of the guinea pig"Neurosci.Lett.. 305. 111-114 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takimoto, Aoyama, K.tanaka, et al.: "Augmented erpression of neuronal NOS in the atria parasympathetically decreases heart vate during acute MI in rats"Civculation. 105. 490-496 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koichi Tanaka and Tanemichi Chiba: "The origin of sensory nerves supplying the peritoneum"Acta anatomica Nipponica. 75-1. 128 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koichi Tanaka, Toshiko Matsugami, and Tanemichi Chiba: "The sensory innervation of peritoneum"Autonomic Neuroscience : Basic and Clinical. 82. 49-50 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koichi Tanaka, Akinori Takanaga, Tetsu Hayakawa, Seishi Maeda, and Makoto Seki: "The intrinsic origin of nitric oxide synthase immuno-Reactive nerve fibers in the right atrium of the guinea Pig"Neurosci. Left. 305. 111-114 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshihilo Takimoto, Takeshi Aoyama, Koichi Tanaka, Reiko Keyamura, Yoshiki Yui, Shigetake Sasayania: "Augmented expression of ncuronal nctiric oxide synthase in the atria parasympathetically decreases heart rate during acute myocardial infarction in rats"Cerculation,. 105. 490-496 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 田中宏一, 千葉胤道: "ラット腹膜の知覚神経の起始"解剖誌. 75(1). 128 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Koichi Tanaka, T.Matsugami, T.Chiba: "The sensory innervation of peritoneum"Autonomic Neurosciencei Basic and Clinical. 82. 49-50 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Koichi Tanaka et al.: "The intrinsic origin of NOS-ir nerve fibers in the right atrium of the guinea pig"Neurosci Lett.. 305. 111-114 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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