| Project/Area Number |
12670175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | DOKKYO UNIVERSITY SCHOOL OF MEDICINE |
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Principal Investigator |
MASAWA Nobuhide Dokkyo University School of Medicine, ProfessorA, 医学部, 教授 (60165694)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2000: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Vasucular Dementia / Cerebral Arteriosclerosis / Cerebral Arteriolosclerosis / Medial Necrosis / Medial Fibrosis / Morphometry / Three-Dimensional (3D) / Hemodynamics / 脳内最小動脈硬化 |
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| Research Abstract |
Artery size varied according to both the wall thickness and the composition (remodeling). Cerebral arteriosclerosis is regarded as a major contributing factor for diffuse white matter lesions of the brains in patients with vascular dementia. The pathogenesis of the lesions is still unknown. The aim of this study was to investigate the modality of the morphologic remodeling and to reveal three-dimensional (3D) distribution of the cerebrovascular lesions.
Twenty-six autopsy brains of patients with vascular dementia were investigated light- and electron- microscopically. Morphometric and 3D reconstructive study were carried out by means of computer-assisted analysis system (OZ for 3D reconstruction system, version 3.01, Rise Co.).
Small vessels in the white matter lesions were thickened with the increase of collagen fibers consisting largely of type I, III & V. Perivascular CD 68-positive cells in the white matter were much sparser than in the cortex (p<0.05). Proximal small arteries supplying the white matter lesions showed medial necrosis or atrophy without stenosis, which is characteristic of hypertensive arterial changes. The 3D analysis revealed the marked medial lesions adjacent to the curved portion of medullary artery (MA) or to the bifurcation of perforating artery (PA). In the arterial cross sections having less than 40% stenosis, there was a highly significant linear relationship between intimal thickening and arterial enlargement at the definite location of distal ICA, MCA (M2), PA and long MA. These findings suggest that the functional circulatory disorder of the proximal small arteries should cause the medial necrosis and marked fibrous thickening, and that the decreased clearance between blood and brain should play roles in the pathogenesis of the deep white matter lesions associated with vascular dementia.
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