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Patho- and morphogenesis of Kikuchi's disease

Research Project

Project/Area Number 12670182
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionFukuoka University

Principal Investigator

KIKUCHI Masahiro  Fukuoka Univ. Sch. Med. Prof., 医学部, 教授 (80078774)

Co-Investigator(Kenkyū-buntansha) SUZUMIYA Junji  Fukuoka Univ. Sch. Med. Assoc. Prof., 医学部, 助教授 (70206556)
OHSHIMA Koichi  Fukuoka Univ. Sch. Med. Assoc. Prof., 医学部, 助教授 (50203766)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2002: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsKikuchi-Fujimoto disease / Histiocytic necrotizing lymphadenitis / Apoptosis / Lymph node / Cytokine / Plasmacytoid monocyte / Myeloperoxydase / Caspase 6 / caspase 19 / モノカインMig / IP-10 / IL-18 / Mig / インターフェロンγ / IL18 / アポトーシス / ミエロペロキシダーゼ
Research Abstract

Kikuchi's disease is the disease entity defined by histological findings, but the disease has characteristic clinical features such as occurrence of young and adolescence with preference of female, swelling of neck lymph nodes with tenderness, fever, leukopenia under 4000 /mm^3, occasional skin rashes and excellent prognosis. These clinical findings were similar during these investigated years, but male ratio was slightly increased recently. Investigated disease specific proteins in serum and DNA in affected site could not detected yet. Histological findings were constant, but some recent cases showed pronounced foamy histiocytes with no obvious necrosis. Immunohistochemically myeloperioxidase was positive for proliferating CD4 positive cells, probably of plasmacytoid monocytes and the findings were very useful for cytological diagnosis of the disease by aspiration biopsy. The disease related obviously apoptotic process and both fas and fas ligands, and perforin granzyme pathways and the process strongly related to morphogenesis of the disease. Fas pathway related CXC chemokine, IP-10, monokine and Mig and perforin pathway related chemokine IL 18 also expressed in the affected foci. For the apoptotic process examined by gene chip, many apoptosis promoting chemokine concerning such CDC 6, CASP 2 and RIRK1 domain containing adaptor, caspase 6, BCL2 antagonist were up-regulated and apoptosis suppressed chemokine such as cyclin-dependent kinase 5, glyceraldehyde-3-phosphate dehydrogenase, quiesin Q6 and BCL2-related myeloid cell leukemia sequence were down-regulated. From these findings Kikuchi's disease has very strong promoting process of apoptosis and it is very important to clear the inducible cause of this apoptotic process and also the disease is very useful for investigation of apoptotic process.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Ohshima, K., Haraoka, S., Harada, S., et al.: "Hepatosplenic γδ T-cell lymphoma : relation to Epstein-Barr virus and activated cytotoxic molecules"Histopathol.. 36. 127-135 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohshima, K., Haraoka, S., Suzumiya, J., et al.: "Cytoplasmic cytokines in lymphoproliferative disorders : multiple cytokine production in angioimmunoblastic lymphadenopathy with dysproteinemia"Leukemia and Lymphoma. 38. 541-545 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, K., Ohshima, K., Anzai, K., et al.: "Elevated stem-soluble Fas ligand in histiocytic necrotizing lymphadenitis"Int. J. Hematol.. 73. 84-86 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzumiya, J., Ohshima, K., Takada, T., et al.: "Prevalence of Bartonella henselae in granulomatous lymphadenitis : a useful tool for the diagnosis of cat-scratch disease by polymerase chain reaction"J. Clin. Exp. Hematol.. 41. 101-106 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohshima, K., Haraoka, S., Takahata, Y., et al.: "Interferon-γ, interleukin-18, monokine induced by interferon-γ and interferon-γ-inducible proetein-10 in histiocytic necrotizing lymphadenitis"Leukemia and Lymphoma. 43. 1115-1120 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 菊池 昌弘: "内科100年のあゆみ(血液) II.日本人の貢献 7.菊池病"日内会誌(創刊100周年記念号). 91. 103-104 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kikuchi, M.: ""Surgical Pathology Update 2001" Differential Diagnosis in Lymph Node Biopsy : Viral lesions in lymph nodes"ABW. Wissenschaftsverlag. 585 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohshima, K., Suzumiya, J., Kanda, M., Haraoka, S., Kawasaki, C., Shimazaki, K., Kikuchi, M.: "Genotypic and phenotypic alterations in Epstein-Barr virus-associated lymphoma"Histopathol.. 35. 539-550 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohshima, K., Haraoka, S., Harada, S., Kamumura, T., Suzumiya, J., Kanda, M., Kawasaki, C., Sugihara, M., Kikuchi, M.: "Hepatosplenic γδT-cell lymphoma: relation to Epstein-Barr virus and activated cytotoxic molecules"Histopathol.. 36. 127-135 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzumiya, J., Ohshima, K., Kanda, M., Kumagawa, M., Nagano, M., Hirata, M., Nawa, Y., Tamura, K., Kikuchi, M.: "Epstein-Barr virus (EBV)-induced B-cell proliferative disorder after chemotherapy in a patient with hemophagocytic lymphohistiocytosis with associated EBV-induced T-cell proliferation"Leuk. Lymph.. 37. 593-604 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Abe, Y., Muta, K., Ohshima, K., Yasumoto, S., Shiratsuchi, M., Saito, R., Tsuchiya, T., Shibata, T., Furue, M., Kikuchi, M., Nishimura, J., Nawata, H.: "Subcutaneous panniculitis by Epstein-Barr virus-infected natural killer (NK) cell proliferation terminating in aggressive subcutaneous NK cell lymphoma"Am. J. Hematol.. 64. 221-225 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohshima, K., Haraoka, S., Suzumiya, J., Kawasaki, C., Kanda, M., Kikuchi, M.: "Cytoplasmic cytokines in lymphoproliferative disorders: multiple cytokine production in angioimmunoblastic lymphadenopathy with dysproteinemia"Leuk. Lymph.. 38. 541-545 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Shimazaki, K., Ohshima, K., Suzumiya, J., Kawasaki, C., Kikuchi, M.: "Evaluation of apoptosis as a prognostic factor in myelodysplastic syndromes"Brit. J. Haematol.. 110. 584-590 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohshima, K., Haraoka, S., Sugihara, M., Suzumiya, J., Kawasaki, C., Kanda, M., Kikuchi, M.: "Amplification and expression of a receptor for Fas ligand (DcR3) in virus (EBV or HTLV-1) associated lymphomas"Cancer Letters. 160. 89-97 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kato, K., Ohshima, K., Anzai, K., Suzumiya, J., Kikuchi, M.: "Elevated stem-soluble Fas ligand in histiocytic necrotizing lymphadenitis"Int. J. Hematol.. 73. 84-86 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Suzumiya, J., Ohshima, K., Takada, T., Kanda, M., Tamura, K., Kikuchi, M.: "Prevalence of Bartonella henselae in granulomatous lymphadenitis: A useful tool for the diagnosis of cat-scratch disease by polymerase chain reaction"J. Clin. Exp. Hematol.. 41. 101-106 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohshima, K., Haraoka, S., Takahata, Y., Takada, H., Tsuchiya, T., Suzuki, K., Suzumiya, J., Kikuchi, M.: "Interferon-gamma, interleukin-18, monokine induced by Interferon-gamma and Interferon-gamma-inducible protein-10 in histiocytic necrotizing lymphadenitis"Leuk. Lymph.. 43. 1115-1120 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsutsumi, S., Ohga, S., Nomura, A., Takada, H., Sakai, S., Ohshima, K., Sumimoto, K., Hara, T.: "CD- CD8- T-cell polymyositis in a patient with chronic active Epstein-Barr virus infection"Am. J. Hematol.. 71. 211-215 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kikuchi, M.: "Differential Diagnosis in Lymph Node Biopsy: Viral lesions in lymph nodes, in Surgical Pathology Update 2001"ABW. Wissenschaftsverlag. 406-409 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohshima, K., Haraoka, S., Takahata, Y., Takada, H., Tsuchiya, T., Suzuki, K., Suzumiya, J., Kikuchi, M.: "Interferon-gamma, interleukin-18, monokine induced by interferon-gamma and interferon-gamma inducible protein-10 in histolytic necrotizing lymphadenitis"Leuk. Lymph.. 43(5). 1115-1120 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tsutumi, S., Ohga, S., Nomura, A., Takada, H., Sakai, S., Ohshima, K., Sumimoto, K., Hara, T.: "CD-4-CD-8-T-cell polymyositis in a patient with chronic active Epstein-Barr virus infetion"Am. J. Hematol.. 71. 211-215 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 菊池昌弘: "内科100年のあゆみ(血液)II. 日本人の貢献 7.菊池病"日内会誌(創刊100周年記念号). 91(7). 103-104 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 菊池昌弘: "「感染症:病態と病理診断へのアプローチ」リンパ節感染症 infection diseases on lymph nodes"文光堂:「病理と臨床」Vol.21(臨時増刊号). 408 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shimazaki K, Ohshima K, Suzumiya J, et al.: "Evaluation of apoptosis as a prognostic fator in myelodysplastic syndromes"Brit. J. Haematol.. 110. 584-590 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohshima K, Haraoka S, Sugihara M, et al.: "Amplification and expression of a decoy receptor for Fas ligand (DcR3) in virus (EBV or HTLV-I) associated lymphomas"Cancer Letters. 160. 89-97 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suzumiya J, Ohshima K, Takada T, et al.: "Prevalence of Bartonella henselae in granulomatou lymphadenitis : A useful tool for the diagnosis of cat-scratch disease by polymerase chain reaction"J. Clin. Exp. Hematol.. 41. 101-106 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kikuchi M.: ""Surgical Pathology Update 2001" Differential Diagnosis in Lymph Node Biopsy : Viral lesions in lymph nodes"ABW. Wissenschaftsverlag. 585 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ohshima,K., et al.: "Genotypic and phenotypic alterations in Epstein-Barr virus-associated lymphoma."Histopathol.. 35. 539-550 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohshima,K., et al.: "Hepatosplenic γδ T-cell lymphoma : relation to Epstein-Barr virus and activated cytotoxic molecules."Histopathol.. 36. 127-135 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Suzumiya,J., et al.: "Epstein-Barr virus (EBV)-induced B-cell proliferative disorder after chemotherapy in a patient with hemophagocytic lymphohistiocytosis with associated EBV-induced T-cell proliferation."Leukemia and Lymphoma. 37. 593-604 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Abe,Y., et al.: "Subcutaneous panniculitis by Epstein-Barr virus-infected natural killer (NK) cell proliferation terminating in aggressive subcutaneous NK cell lymphoma"Am.J.Hematol.. 64. 221-225 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohshima,K., et al.: "Cytoplasmic cytokines in lymphoproliferative disorders : multiple cytokine production in angioimmunoblastic lymphadenopathy with dysproteinemia."Leukemia and Lymphoma. 38. 541-545 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kato,K., et al.: "Elevated stem-soluble Fas ligand in histiocytic necrotizing lymphadenitis."Int.J.Hematol.. 73. 84-86 (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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