| Project/Area Number |
12670191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
NAKAMURA Shigeo Aichi Cancer Center Research Institute, Researcher, 研究所, 研究員 (80180363)
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| Project Period (FY) |
2000 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 2001: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2000: ¥2,400,000 (Direct Cost: ¥2,400,000)
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| Keywords | Malignant lymphoma / MALT lymphoma / t(11;18) translocation / API2 / MALT1 / chimeric transcript / Helicobacter pylori / Eradication / T(11;18)(q21;q21) / paracaspase / 病理学 / 生物学 |
|---|
| Research Abstract |
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type constitutes a distinct disease entity. However, its molecular pathogenesis has remained to be elucidaeted. Recently we studied genetic alteration on t(11;18) chromosomal translocation sometimes found on MALT lymphoma, and have identified a novel gene, termed as MALT1 by us, on chromosome 18. Subsequently, we reported that an API2-MALT1 chimeric transcript was mediated by this chromosomal translocation. We further developed the detection system of API2-MALT1 chimeric transcript on the PCR method, and applied the clinisopthologic study of gastric MALT lymphoma. We succeeded to demonstrate that gastric API2-MALT1 chimeric transcript-positive MALT lymphoma generally features unresponsiveness to antibacterial treatment and that this lymphoma is thought to be unrelated to H.pylori infection in its pathogenesis. Further investigation is needed for clarifying the pathogenesis of MALT lymphoma.
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