| Project/Area Number |
12670450
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | ASAHIKAWA MEDICAL COLLEGE |
|---|
Principal Investigator |
SAITOH Yusuke ASAHIKAWA MEDICAL COLLEGE, THIRD DEPT. INT. MED., ASSOCIATE PROFESSOR, 医学部, 助教授 (30281900)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WATARI Jiro ASAHIKAWA MEDICAL COLLEGE, THIRD DEPT. INT. MED., INSTRUCTOR, 医学部, 助手 (10311531)
KOHGO Yutaka ASAHIKAWA MEDICAL COLLEGE, THIRD DEPT. INT. MED., PROFESSOR, 医学部, 教授 (10133183)
|
|---|
| Project Period (FY) |
2000 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
|
|---|
| Keywords | FLATAND DEPRESSED TYPE COLORECTAL TUMORS / DYE SPRAYING METHOD / AMERICAN POPULATION / 色素撒布 / 日米の頻度 |
|---|
| Research Abstract |
In order to assess the prevalence offlat and depressed (F&D) colorectal adenomas in this country, we performed a prospective study ot 211 American patients, using dye-assisted colonoscopy in the presence of both an American and a Japanese investigator 22.7 % of patients had flat and depressed lesions and these were more likely to be adenomatous as compared with polypoid lesions (82 % versus 67%; P = 0,03) and contained more cancer (6% versus 0%; P = 0.04), which also appeared to be at a disproportionately advanced stage. The average size of all F ＆ D advanced lesions (high grade dysplasia and cancer) was significantly smaller than comparable polypoid lesions (10.75 + 2.7 mm versus 20 + 2.9 mm; P < 0.05). F＆D adenomas exhibited significantly stronger FHTT (fragile histidine triad) expression and lower p53 reactivity than similarly sized polypoid adenomas whereas proliferative and apoptotic indices were similar in both groups. We conclude that there is a significant prevalence of colonic flat and depressed colorectal adenomas in this country and that these lesions have significantly different biological features as compared with polypoid lesions. The clinical and epidemiological implications of these findings for American patients needs to be addressed in further studies.
|
