Transgenic Mouse of Hepatitis C Virus Infection
| Project/Area Number |
12670464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OHNISHI Shin The University of Tokyo, Department of Gastroenterology, Assistant Professor, 医学部・附属病院, 講師 (00183236)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Hepatitis C Virus / Transgenic Mouse / Virus Receptor / CD81 / C型肝炎ウイルス |
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| Research Abstract |
Hepatitis C virus (HCV) binds to human CD81 through the E2 glycoprotein. We produced transgenic mice (B6) expressing the human CD81 protein. Those mice lack expression of endogenous mouse CD81.
Those mice were resistant to HCV infection. We thought that expression of human CD81 alone is insufficient to confer susceptibility to HCV infection in the mouse or B6 mice were resistant to HCV infection. We try to make another strain transgenic mouse model. The presence of additional factors for HCV infection may be required.
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Report
(3 results)
Research Products
(12 results)
