| Project/Area Number |
12670631
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kurume University |
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Principal Investigator |
SHOJI Hiroshi Kurume University, Professor, 医学部, 教授 (90122621)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIYAMA Takashi Yamaguchi University, Lecturer, 医学部, 講師 (20263767)
EIZURU Yoshito Kurume University, Professor, 医学部, 教授 (00041351)
AYABE Mitsuyoshi Kurume University, Lecturer, 医学部, 講師 (40232003)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | acute encephalitis / limbic encephalitis / cytokine / 単純ヘルペス脳炎 / 急性辺縁系脳炎 / 傍腫瘍性辺縁系脳炎 |
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| Research Abstract |
Non-herpetic acute limbic encephalitis (non-herpetic ALE) is regarded as a new subgroup of limbic encephalitis. In the present study, clinical findings and cerebrospinal fluid (CSF) cytokines in non-herpetic ALE were investigated. For adult inpatients in our hospital and related hospitals from 1996 to 2001, non-herpetic ALE was examined according to our criteria. In CSF samples of the 6 patients with non-herpetic ALE and 6 patients with herpes simplex encephalitis (HSE), the concentrations of TNF- α, IL-1β, IL-6, and IFN)- γ in CSF were determined with sandwich-type ELISA kits. Six patients were newly diagnosed with non-herpetic ALE in this study. These patients revealed uniformly acute limbic encephalitis, and MRI abnormalities in the bilateral hippocampi and amygdala. Levels of CSF IL-6 and IFN- γ in patients with non-herpetic ALE were significantly lower than those in patients with HSE, probably reflecting an immunological process.
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