| Project/Area Number |
12670809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAMURA Koichiro Faculty of Medicin, The University of Tokyo, Lecturer, 医学部・附属病院, 講師 (60175502)
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|---|
| Project Period (FY) |
2000 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | skin / Langerhans cells / prion / Thy-1 dendritic epidermal T cells / CD40 / TNF-α / プリオン |
|---|
| Research Abstract |
The modulation of expressions of cellular prion-related protein was examined in skine immune cells such as ep demal Langerhans cells (LC) and kesahisocyles (KC). The presence of prp^c on LC,DC in the skin, and KC was demonstrated in immunohis to chenical stauning, immunoblot and FACS, PrPc knock out mice showed negative PrPC expression on these cells and γδ^+TCR dendritic epidemal T cells (DETC ).In uitro examination revealed that TNFα, IL-1β uprequlated R-P^c expresnin on LC, and GM-CSF down requlated this expression. These data suggist that LC and KC may be the targets for peripheral in fection with prion proteins.
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