| Project/Area Number |
12670952
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University School of Medicine |
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Principal Investigator |
ISEKI Eizo Yokohama City University School of Medicine, associate professor, 医学部, 助教授 (30203061)
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| Co-Investigator(Kenkyū-buntansha) |
ODAWARA Toshinori Yokohama City University School of Medicine, the sane clove, associate professor, 医学部附属病院, 助教授 (00244426)
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| Project Period (FY) |
2000 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2003: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | dementia with Lewy bodies / Lewy body / α-synuclein / phosphorylated raw / frontotemporal / Pick's disease / ubiquitin / 皮質基底核変性症 / 進行性核上性麻痺 / シンフィリン-1 / タウ / 無性 / 遺伝子異常 / 診断基準 / 細胞骨格 |
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| Research Abstract |
The study concerning the pathogenesis of non-Alzheimer neurodegenerative dementias has been performed from the perspective of abnormal cytoskeletons. Cytopathological and clinicopathological studies of dementia with Lewy bodies (DLB) have been focused. In the cytopathological studies, formation process or degeneration process of Lewy bodies was investigated using α-synuclein immunohistochemistry. Lewy bodies were formed by the accumulation of α-synuclein in the abnormal cytoskeletons with axonal transport blockage, and degenerated with glial and immunological reaction. In the clinicopathological studies, Lewy pathology was graded from stage I to stage IV, and autopsied cases of DLB were classified into some subtypes according to the degree of Lewy pathology or Alzheimer pathology. In frontotemporal dementia (FTD), Pick's disease (PiD) was divided into two types of tauopathy and ubiquitinopathy.
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