| Project/Area Number |
12671024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
|
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| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
SEKI George Faculty of Medicin, The University of Tokyo, Assistant, 医学部・附属病院, 助手 (30206619)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NOIRI Eisei Faculty of Medicin, The University of Tokyo, Assistant, 医学部・附属病院, 助手 (00301820)
|
|---|
| Project Period (FY) |
2000 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,600,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | NBC-1 / RTA / Cataracts / glaucoma / band keratepathy / hand keratopathy / ナトリウム重炭酸共輸送体 / 近位尿細管性アシドーシス / 白内障 / 緑内障 / 帯状角膜変性症 |
|---|
| Research Abstract |
Mutations in Na-HCO3 cotransporter (NBC-1) cause proximal renal tubular acidosis with ocular abnormalities. We have examined the localization of NBC-1 in the eye, and found that NBC-1 is present in the corneal endothelium, ciliary epithelium, trabecular meshwork, and lens epithelium. We also found NBC-1 activity in human lens epithelial cells. These findings could explain the occurrence of ocular abnormalities associated with NBC-1 inactivation.
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