| Project/Area Number |
12671062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOZUMA Shiro The University of Tokyo, Obstetrics & Gynecology, A. Professor, 医学部・附属病院, 助教授 (10272569)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Akihiko The University of Tokyo, Obstetrics & Gynecology, research associate, 医学部・附属病院, 助手 (10280942)
FUJII Tomoyuki The University of Tokyo, Obstetrics & Gynecology, Lecturer, 医学部・附属病院, 講師 (40209010)
BABA Kazunori The University of Tokyo, Medical Engineering, A. Professor, 大学院・医学系研究科, 助教授 (30181035)
MARUMO Genzo The University of Tokyo, Obstetrics & Gynecology, research associate, 医学部・附属病院, 助手 (60282646)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | umbilical cord / periventricular leubomalacia / fetal sheep / 脳室周囲白室軟化症 |
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| Research Abstract |
We characterized the detailed hemodynamics of fetal blood pressure, heart rate, umbilical blood flow and carotid blood flow responses to partial compression of the umbilical cord and tested the hypothesis that repeated partial umbilical cord compression is a predisposing factor to genesis of periventricular leukomalacia. In chronically instrumented fetal sheep at 120-130 days of gestation, partial compression of the umbilical cord was induced 15 times, each for 2 min at 2 min intervals. Each cord copression reduced umbilical blood flow by 50%.
In an early stage of the compression experiment, carotid arterial blood flow increased and carotic arterial resistance decreased, however, the resistance was gradually raised by repetition of compression and finally higher than the basal level. This result demonstrates that fetal brain circulation may be modified by preexposure to repeated intrauterine challenges.
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