Gene therapy for thrombosis

Research Project

Project/Area Number	12671315
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Thoracic surgery
Research Institution	KYUSHU UNIVERSITY
Principal Investigator	NISHIDA Takahiro Faculty of Medicine, KYUSHU UNIVERSITY, Aso. Prof., 医学部・附属病院, 助手 (50284500)
Co-Investigator(Kenkyū-buntansha)	MASUDA Munetaka Faculty of Medicine, KYUSHU UNIVERSITY, Ass. Prof., 医学部・附属病院, 講師 (10190365) UENO Hikaru Univ. of Occupational and Environmental Health, KYUSHU UNIVERSITY, Prof., 医学部, 教授 (50260378) 富永隆治九州大学, 大学院・医学研究院, 助教授 (70136464)
Project Period (FY)	2000 – 2001
Project Status	Completed (Fiscal Year 2001)
Budget Amount *help	¥3,300,000 (Direct Cost: ¥3,300,000) Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000) Fiscal Year 2000: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywords	Thrombosis / Gene transfer / TFPI / 血栓予防 / 静脈グラフト / TFPI / 血栓症
Research Abstract	A combination of rTFPI irrigation and TFPI gene transfer overcomes the shortcomings shown by each method when used alone and achieves a full coverage of TF activity suppression, thereby enhancing their therapeutic effects without systemic side effects. This combination mya be an effective strategy for the prevention of thrombosis and proliferative changes after angioplasty in humans.