| Project/Area Number |
12671420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KATOH Shinsuke (2001) The University of Tokushima, School of Medicine, Associate Professor, 医学部, 助教授 (30243687)
武田 芳嗣 (2000) 徳島大学, 医学部・附属病院, 講師 (20243694)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Riichi The University of Tokushima, Faculty of Engineering, Professor, 工学部, 教授 (00112235)
SAIRYO Koichi The University of Tokushima, School of Medicine, Lecturer, 医学部, 講師 (10304528)
加藤 真介 徳島大学, 医学部, 助教授 (30243687)
酒巻 忠範 徳島大学, 医学部・附属病院, 医員(臨床)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | SPONDYLOLYSIS / SPONDYLOLISTHESIS / ENDPLATE-LESION / BIOMECHANICS / ADOLESCENTS |
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| Research Abstract |
In this study, we clarified when the slippage occurred in the pediatric spondylolysis clinically, and proposed the possible pathomechanism based on the biomechanical analysis using fresh cadaveric lumbar spines. The slippage was revealed to appear at the cartilaginous skeletal stage, which is the most immature stage of the vertebral body. The biomechanical study demonstrated that the growth plate of the vertebral body was mechanically weaker against the anterior shear force, as the skeletal stage was more immature. From those investigations, the vertebral anterior slippage in the spondylolytic spine among the pediatric popuration was shown to occur at the growth plate, and the mechanical weakness of growth plate was considered to be the key factor for the development of the slip. To understand the pathogenesis of the slippage clearly, we created an animal model mimicking, the slippage and wedging deformities in the pediatric spondylolysis. The radiographs three weeks after lumbar posterior destabilization surgery of 4-week-old immature rats showed that the vertebral anterior slippage and wedging deformity. Thus, this model was confirmed to be an appropriate animal model for investigate the pathogenesis ofpediatric isthmic spondylolisthesis. Histological analysis of this model obviously demonstrated growth plate injury three weeks after the surgery. Furthermore, normal growth plate disappeared at the anterior corner of the vertebral body. These results let us conclude that growth plate injury was the main lesion of the associated slippage and deformities with lumbar spondylolysis in pediatrics.
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