• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Correlation of Vascular endothelial growth factor with metastasis of prostate cancer

Research Project

Project/Area Number 12671563
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionNihon University

Principal Investigator

HACHIYA Takahiko  School of medicine, Department of Urology, Nihon University, Lecturer, 医学部, 助手 (40228482)

Co-Investigator(Kenkyū-buntansha) OKADA Kiyoki  School of medicine, Department of Urology, Nihon University, Professor, 医学部, 教授 (70059301)
HIRANO Daisaku  School of medicine, Department of Urology, Nihon University, Lecturer, 医学部, 助手 (40228804)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2000: ¥3,000,000 (Direct Cost: ¥3,000,000)
KeywordsProstate cancer / Metastasis / VEGF / Progression / Risk factor of progression
Research Abstract

We evaluated the outcome following radical prostatectomy in Japanese men with clinically localized prostate cancer with special reference to vascular endothelial growth factor in order to provide information about long-term survival.
Seventy-eight otherwise healthy patients with clinically localized prostate cancer underwent radical prostatectomy. Immunohistochemical VEGF staining and labeling index were evaluated for statistical purposes. Treatment outcomes were measured in terms of PSA failure, clinical progression free survival and prostate cancer specific survival with special reference to VEGF. Cox proportional model was used to determine the most important factors including VEGF, which may influence progression prostate cancer specific-survival. Of the 78 patients, 25 had negative VEGF staining, 53 had positive VEGF.
In terms of PSA failure free survival, clinical progression free survival and prostate cancer specific-survival there was not a statistically significant difference between VEGF negative tumors and VEGF positive tumors. On Cox multivariate analysis, only tumor grade alone approached statistical significance. Cox multivariate analysis revealed that VEGF was not a statistically significant independent predictor of progression. VEGF was not significantly correlated with tumor extension, differentiation, progression and survival. Therefore VEGF expression was inadequate and failed to provide any additional prognostic information.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] 蜂矢隆彦, 岡田清己: "前立腺全摘除術、術式とQOL"日本臨床、2000年増刊. 58, 増刊号. 386-388 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岡田清己, 蜂矢隆彦: "V.前立腺癌の治療 手術療法 手術療法の歴史"日本臨床2000年増刊. 58, 増刊号. 239-246 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahiko Hachiya, Kiyoki Okada: "Prediction of organ-confined disease by PSA nadir after neoadjuvant therapy..."Int. J. Urol. 7, 11. 393-401 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 蜂矢隆彦, 岡田清己: "前立腺癌のホルモン療法の現況"Biotherapy. 14, 11. 1103-1110 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 蜂矢隆彦, 岡田清己: "前立腺癌の治療-Neoadjuvant療法,Adjuvant療法の臨床的意義"クリニカ. 28, 2. 51-55 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 蜂矢隆彦, 岡田清己: "偶発前立腺癌/限局性前立腺癌/局所進展前立腺癌の治療"Modern Physician. 21, 9. 1225-1258 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 蜂矢隆彦, 岡田清己: "第3章悪性腫瘍の病態と治療の最前線、4前立腺.先端医療シリーズ"泌尿器科、診断と治療の最前線(先端医療技術研究所.2000). 6 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahiko Hachiya, Kiyoki Okada.: "Radical prostatectomy, procedure and quality of life"Nipponrinsho, 2000. 58. 386-388 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahiko Hachiya, Kiyoki Okada: "Prediction of organ-confined diseae by PSA nadir after neoadjuvant therapy..."Int. J. Urol. 7, 11. 393-401 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahiko Hachiya. Kiyoki Okada.: "Recent perspectives of hormonal therapy for prostate cancer"Biotherapy. 14, 11. 1103-1110 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 蜂矢隆彦, 岡田清己: "前立腺全摘除術、術式とQOL"日本臨床、2000年増刊. 58,増刊号. 386-388 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 岡田清己, 蜂矢隆彦: "V.前立腺癌の治療 手術療法 手術療法の歴史"日本臨床2000年増刊. 58,増刊号. 239-246 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahiko Hachiya, Kiyoki Okada: "Prediction of organ-confined disease by PSA nadir after neoadjuvant therapy…"Int.J.Urol. 7, 11. 393-401 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 蜂矢隆彦, 岡田清己: "前立腺癌のホルモン療法の現況"Biotherapy. 14, 11. 1103-1110 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 蜂矢隆彦, 岡田清己: "前立腺癌の治療-Neoadjuvant療法,Adjuvant療法の臨床的意義"クリニカ. 28, 2. 51-55 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 蜂矢隆彦, 岡田清己: "偶発前立腺癌/限局性前立腺癌/局所進展前立腺癌の治療"Modern Physician. 21, 9. 1225-1258 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 蜂矢隆彦, 岡田清己: "泌尿器科、診断と治療の最前線、第3章悪性腫瘍の病態と治療の最前線、4 前立腺.先端医療シリーズ"先端医療技術研究所.2000. 6 (2000)

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2000-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi