Fundamental Research About Nerve Network Around Flap Pedicle Vessels

• Project/Area Number: 12671747
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Nagoya University
• Principal Investigator: TORIYAMA Kazuhiro University Hospital,Nagoya University,Assistant Professor, 医学部・附属病院, 講師 (40314017)
• Co-Investigator(Kenkyū-buntansha): TORII Shuhei Graduate Schook of Medicinef Nagoya University,Professor, 大学院・医学研究科, 教授 (60115607) ; HONDA Takashi Fukushima Med. University School of Medicine,Assistant Professor, 医学部, 講師 (20165608)
• Project Period (FY): 2000 – 2001
• Project Status: Completed (Fiscal Year 2001)
• Budget Amount: ¥3,500,000 (Direct Cost: ¥3,500,000); Fiscal Year 2001: ¥600,000 (Direct Cost: ¥600,000); Fiscal Year 2000: ¥2,900,000 (Direct Cost: ¥2,900,000)
• Keywords: calcitonin gene-related peptide / the femoral artery / the femoral nerve / the genitofemoral nerve / the sympathyetic nerve / reconstruction surgery / perivascular nerve / CGRP陽性神経 / 神経進入経路 / トレーサー

Research Abstract

It is important to know the anatomical relation between perivascular nerve fibers and blood vessels for the reconstruction surgery. The origin and innervating pathways of perivascular nerve fibers containing calcitonin gene related peptide (GGRP) around the femoral artery were examined by immunohistochemical staining combined with denervation methods and/or retrograde labeling methods.
CGRP-immunoreactive (CGRRr) fibers around the femoral artery formed a complicated network with numerous thin fibers branching from nerve fiber bundles in the perivascular connective tissue. These fibers were directly supplied from the peripheral nerves, mainly the femoral nerve, the genitofemoral nerve and the sympathetic nerve, which issued from the same segment (L1-L4 dorsal root ganglia) as the somatic sensory nerve fiber, although the innervating pathways to the femoral artery probably took different courses.