Development of analyzing system for studying human dental pulp repair
| Project/Area Number |
12671856
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
NAGAOKA Shigetaka Kagoshima University, Dental School, Associate Professor, 歯学部, 助教授 (10155913)
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| Co-Investigator(Kenkyū-buntansha) |
MOTOO Kitano Kagoshima University, Dental School, Professor, 歯学部, 教授 (10142118)
TOKUDA Masayuki Kagoshima University, Dental School, Research Associate, 歯学部, 助手 (20253891)
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| Project Period (FY) |
2000 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | dentin-pulp complex / restorative material / pulp capping agent / 象牙質・歯髄複合体 |
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| Research Abstract |
In this study, we investigated the behavior of thick slices from human teeth drilled immediately after extraction and cultured from 3 days to 1 month. Results show that the damaged pulp beneath the cavity is able to develop, in vitro, some typical aspects correlated to tissue healing, evidenced by cell proliferation, neovascularization, and the presence of functional cuboidal cells close to the injured area. After 30 days of culture, elongated spindle-shaped cells can be seen aligned along the edges of the relevant dentin walls, whereas sound functional odontoblasts are well-preserved beneath healthy areas. Tissue recovery leads us to believe that such a culture model will be a useful system for testing factors regulating pulp repair.
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Report
(3 results)
Research Products
(10 results)
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[Publications] Matsusita,K., Motani,R., Sakuta,T., Yamaguchi,N., Koga,T., Matsuo,S., Nagaoka,S., Abeyama,K., Maruyama,I. & Torii,M.: "The role of vascular endolhelial growth factor in human dental pulp cells: Induction, proliferation, and differentiation and activation of the AP-1-dependent signaling pathway"J. Dent. Res.. 79. 1596-1603 (2000)
Description
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[Publications] Oyama,T., Sakuta,T., Matsushita,K., Maruyama,I., Nagaoka,S., Torii,M.Oyama,T., Sakuta,T., Matsushita,K., Maruyama,I., Nagaoka,S., Torii,M.: "Efforts of Roxithromycin on Tumor necrosis Factor-alpha-nduced Vascular Endothelial Growth Factor Expression in Human Periodontal Ligament Cells in Culture"J. Periodont. 71. 1546-1553 (2000)
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[Publications] Sakuta,T., Matsushita,K., Yamaguchi,N., Oyama,T., Motani,R., Koga,T., Nagaoka.S., Abeyama,K., Maruyama,I., & Torii,M.: "Enhanced production of vascular endothelial growth factor by human monocytic cells stimulated with endotoxin through transcription factor SP-1"J. Med. Microbiol. 50. 233-237
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