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Development of antimicrobial denture base resin with antibacterial denatured apatites

Research Project

Project/Area Number 12671911
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionTsurumi University

Principal Investigator

HIRABAYASHI Shigeru  Tsurumi University, School of Dental Medicine, Lecturer, 歯学部, 講師 (30121130)

Co-Investigator(Kenkyū-buntansha) OHSHIMA Tomoko  Tsurumi University, School of Dental Medicine, Lecturer, 歯学部, 講師 (50233101)
MAEDA Nobuko  Tsurumi University, School of Dental Medicine, Professor, 歯学部, 教授 (10148067)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2000: ¥2,800,000 (Direct Cost: ¥2,800,000)
Keywordsdenture base resins / denture plaque / inorganic antibacterial agent / antimicrobial effects / 義歯床用レジン
Research Abstract

The denture plaque control is an important problem in a society composed largely of elderly people. Therefore, to develop antimicrobial denture base resins, the experimental resins in which were added two apatite-based antibacterial agents were prepared and their antimicrobaial effects were investigated. The influences of addition of antibacterial agents on the physical properties of experimental resins were also examined.
A silicate-containing apatite (Si-HAp : Ube Materials) and a silver-sintering apatite (Ag-HAp : Sangi) were used as antibacterial agent. These were added in a commercial denture base resin (Acron Clear : GC) in the range of 3 〜 5 mass%. The durability of antimicobial effects to Candida albicans, flexural strength and color stability of them were examined with aging in water from 0 to 6 months.
The antimicrobial effects of experimental resins were maintained in all experimental groups even at 6 months after immersion in water, although its effect was higher for the resin with Ag-HAp than for the resin with Si-HAp. The flexural strengths of experimental resins decreased about 5〜10 % as compared with that of non-added resin, but there was no significant difference in the elastic modulus and flexural deflection between experimental resins and non-added resin. These flexural properties of experimental resins did not decrease significantly after 6 months in water. The color difference (ΔE^*ab) of experimental resin after 6 months in water to before immersion was about 2.5 for the resins with Ag-HAp and about 4.3 for the resins with Si-HAp. These values were negligible because transparent resin was used as the base resin. From these results, it was suggested that the experimental resins could use in clinical application.

Report

(3 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] 平林 茂: "アパタイト系抗菌剤を添加した義歯床用レジンの抗菌効果"歯科材料・器械. 20・特37. 41 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 平林 茂: "アパタイト系抗菌剤を添加した義歯床用レジンの抗菌効果(第2報)抗菌効果の持続性と変色"歯科材料・器械. 20・特38. 144 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 平林 茂: "アパタイト糸抗菌剤を添加した義歯床用レジンの抗菌効果(第3報)6ヵ月水中浸漬後の抗菌効果と曲げ強さ"歯科材料・器械. 20・特39. (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shigeru HIRABAYASHI: "Antimicrobial effect of denture base resins with apatite-based antibacterial agents"J. J. Dent. Mater.. Vol.20-Special 37. 41 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shigeru HIRABAYASHI: "Antimicrobial effect of denture base resins with apatite-based antibacterial agents (Part 2) Durability of antimicrobial effect and discoloration"J. J. Dent. Mater.. Vol.20-Special 38. 144 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shigeru HIRABAYASHI: "Antimicrobial effect of denture base resins with apatite-based antibacterial agents (Part 3) Antimicrobial effect and bending strength at 6 months after immersion in water"J. J. Dent. Mater.. Vol.20-Special 39. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 平林 茂: "アパタイト系抗菌剤を添加した義歯床用レジンの抗菌効果(第2報) 抗菌効果の持続性と変色"歯科材料・器械. 20・特38. 144 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 平林 茂: "アパタイト系抗菌剤を添加した義歯床用レジンの抗菌効果(第3報) 6ヵ月水中浸漬後の抗菌効果と曲げ強さ"歯科材料・器械. 20・特39. (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 平林茂: "アパタイト系抗菌剤を添加した義歯床用レジンの抗菌効果"歯科材料・器械. 20・特37. 41 (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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