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Investigation of Domestic and Yunnang Plants for Antiproliferative and Anti-HIV Constituents

Research Project

Project/Area Number 12672080
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionFukuoka University

Principal Investigator

OKABE Hikaru  Fukuoka University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (10078678)

Co-Investigator(Kenkyū-buntansha) FUJIOKA Toshihiro  Fukuoka University, Faculty of Pharmaceutical Sciences, Associate Professor, 薬学部, 助教授 (80165357)
NAGAO Tsuneatsu  Fukuoka University, Faculty of Pharmaceutical Sciences, Research Assistant, 薬学部, 助手 (90180455)
ABE Fumiko  Fukuoka University, Faculty of Pharmaceutical Sciences, Research Assistant, 薬学部, 助手 (10090747)
KASHIWADA Yoshiki  Niigata College of Pharmacy, Associate Professor, 助教授 (30169429)
Project Period (FY) 2000 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsAntiproliferative Constituents / Human stomach cancer / Human uterine cancer / Mouse melanoma / Tannins / Flavonoids / Phenylethanoid glycosides / Triterpenoids / 腫瘍細胞増殖抑制作用 / マツカゼソウ / Lippia cancescens / Inula helenium / クマリン / フラボン / セスキテルペン / クマツヅラ科植物 / アレチハナガサ / コバノランタナ / トリテルペン / ポリフェノール / 腫瘍細胞増殖抑制 / ヒト胃ガン細胞 / ヒト子宮頚ガン細胞 / マウス悪性メラノーマ細胞 / 抗腫瘍活性植物成分
Research Abstract

The MeOH extracts of 609 plant materials from 403 species belonging to 98 families were checked for their antiproliferative activity against 3 tumor cell lines, human stomach cancer cell (MK-1), human uterine cancer cell (HeLa), malignant mouse melanoma cell (B16F10). Among them the extracts of 78 plant species showed 50% growth inhibition at the concentration less than 12.5 μg/ml, however, more than half of them were already investigated and the active constituents have been specified. Twenty-four plant extracts among those which have attracted our interests were further fractionated guided by activity, and the constituents were isolated, identified, or the structures of new compounds were determined. Variety of compounds, chalcones, flavones, isoflavones, tannins and related compounds, phenylethanoid glycoside phenylpropanoic acid esters, coumarins, alkaloids, terpenoids, steroids and triterpenids, were isolated and their antiproliferative activities against three tumor cell lines were determined. The details of the results are shown in the report.
Some plant extracts were screened for the anti-HIV activity, however, we could not get the promising results, and the further investigation is now suspended.

Report

(4 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Yoshiki Kashiwada: "Anti-AIDS Agents 38. Anti-HIV Activity of 3-O-Acyl Ursolic Acid Derivatives"Journal of Natural Products. 63. 1619-2000 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiki Kashiwada: "Synthesis and Anti-AIDS Activity of 3-Alkylamido-3-deoxy-betulinic Acid Derivatives"Chemical and Pharmaceutical Bulletin. 48. 1387-1390 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiki Kashiwada: "3,28-Di-O-(dimethylsuccinyl)-betulin Isomers as Anti-HIV Agents"Bioorganic & Medicinal Chemistry Letters. 11. 183-185 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuneatsu Nagao: "Antiproliferative Constituents in the Plants 7. Leaves of Clerodendron bungei and Leaves and Bark of C. trichotomum"Biological and Pharmaceutical Bulletin. 24. 1338-1341 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Junei Kinjo: "Antiproliferative Constituents in the Plant 8. Seeds of Rhynchosia volubilis"Biological and Pharmaceutical Bulletin. 24. 1443-1445 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fumiko Abe: "Antiproliferative Constituents in the Plants 9. Aerial Parts of Lippia dulcis and Lippia canescens"Biological and Pharmaceutical Bulletin. 25. 920-922 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuneatsu Nagao: "Antiproliferative Constituents in the Plants 10. Flavones from the Leaves of Lantana, montevidensis B_<RIQ>. and Consideration of Structure-Activity Relationship"Biological and Pharmaceutical Bulletin. 25. 875-879 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Junei Kinjo: "Activity-Guided Fractionation of Green Tea Extract with Antiproliferative Activity against Human Stomach Cancer Cells"Biological and Pharmaceutical Bulletin. 25. 1238-1240 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tenji Konishi: "Antiproliferative Sesquiterpene Lactones from the Roots of Inula helenium"Biological and Pharmaceutical Bulletin. 25. 1370-1372 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Junei Kinjo: "Antiproliferative Activity of Phenylpropanoid Ester Glycosides from Ligstrum purpurascens"Natural Medicines. 56. 136-138 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toshihiro Fujioka: "Antiproliferative Constituents from Umbelliferae Plants VI. New Ursane-Type Saikosaponin Analogs from the Fruits of Bupleurum rotundifolium"Chemical and Pharmaceutical Bulletin. 51. 365-372 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiki Kashiwada, et al.: "Anti-AIDS Agents 38. Anti-HIV Activity of 3-O-Acyl Ursolic Acid Derivatives"Journal of Natural Products. 63. 1619-1622 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiki Kashiwada, et al.: "Synthesis and Anti-HIV Activity of 3-Alkyl-amido3-deoxy-betulinic Acid Derivatives"Chemical and Pharmaceutical Bulletin. 48 (9). 1387-1390 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshiki Kashiwada, et al.: "3,28-Di-O-(dimethylsuccinyl)-betulin Isomers as Anti-HIV Agents"Bioorganic & Medicinal Chemistry Letters. 11. 183-185 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuneatsu Nagao, et al.: "Antiproliferative Constituents in the Plants 7. Leaves of Clerodendron bungei and Leaves and Bark of C. trichotomum"Biological and Pharmaceutical Bulletin. 24 (11). 1338-1341 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Junei Kinjo, et al.: "Antiproliferative Constituents in the Plant 8. Seeds of Rhynchosia volubilis"Biological and Pharmaceutical Bulletin. 24 (12). 1443-1445 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fumiko Abe, et al.: "Antiproliferative Constituents in the Plant 9. Aerial Parts of Lippia dulcis and Lippia canescens"Biological and Pharmaceutical Bulletin. 25 (7). 920-922 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsuneatsu Nagao, et al.: "Antiproliferative Constituents in the Plant 10. Flavones from the Leaves of Lantana montevidensis B_<RIQ.> and Consideration of Structure-Activity Relationship"Biological and Pharmaceutical Bulletin. 24 (11). 1338-1341 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Junei Kinjo, et al.: "Activity-Guided Fractionation of Green Tea Extract with Antiproliferative Activity against Human Stomach Cancer cells"Biological and Pharmaceutical Bulletin. 25 (9). 1238-1240 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tenji Konishi, et al.: "Antiproliferative Sesquiterpene Lactones from the Root of Inula helenium"Biological and Pharmaceutical Bulletin. 25 (10). 1370-1372 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Junei Kinjo, et al.: "Antiproliferative Activity of Phenylpropanoid Ester Glycosides from Ligstrum purpurascens"Natural Medicines. 56 (4). 136-138 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toshihiro Fujioka, et al.: "Antiproliferative Constituents from Umbelliferae Plants VI. New Ursane-Type Saikosaponin Analogs from the Fruits of Bupleurum rotundifolium"Chemical and Pharmaceutical Bulletin. 51 (4). 365-372 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Fumiko Abe: "Antiproliferative Constituents in Plants 9. Aerial Parts of Lippia dulcis and Lippia canescens"Biological and Pharmaceutical Bulletin. 25・7. 920-922 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tsuneatsu Nagao: "Antiproliferative Constituents in Plants 10. Flavones from the Leaves of Lantana montevidensis BRIQ. and Consideration of Structure-Activity Relationship"Biological and Pharmaceutical Bulletin. 25・7. 875-879 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Junei Kinjo: "Activity-Guided Fractionation of Green Tea Extract with Antiproliferative Activity against Human Stomach Cancer Cells"Biological and Pharmaceutical Bulletin. 25・9. 1238-1240 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tenji Konishi: "Antiproliferative Sesquiterpene Lactones from the Roots of Inula helenium"Biological and Pharmaceutical Bulletin. 25・10. 1370-1372 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toshihiro Fujioka: "Antiproliferative Constituents from Umbelliferae Plants VI. New Ursane-Type Saikosaponin Analogs from the Fruits of Bupleurum rotundifolium"Chemical and Pharmaceutical Bulletin. 51・4. (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Nagao, F.Abe, H.Okabe: "Antiproliferative Constituents in the Plants 7. Leaves of Clerodendron bungei and Leaves and Bark of C. trichotomum"Biological and Pharmaceutical Bulletin. 24・11. 1338-1341 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] J.Kinjo, T.Nagao, T.Tanaka, G.Nonka, H.Okabe: "Antiproliferative Constituents in the Plants 8. Seeds of Rhynchosia volubilis"Biological and Pharmaceutical Bulletin. 24・12. 1443-1445 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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