| Project/Area Number |
12672220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
応用薬理学・医療系薬学
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| Research Institution | Tohoku Parmaceutical University |
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Principal Investigator |
SAKURADA Shinobu Tohoku Pharmaceutical University, Department of Physiology and Anatomy, Professor, 薬学部, 教授 (30075816)
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| Project Period (FY) |
2000 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2003: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2002: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | mu-opioid receptor antagonist / mu1-opioid receptor / mu2-opioid receptor / endomorphin-1 / endomorphin-2 / naloxonazine / β-funaltrexamine / D-Pro^2-endomorphins / D-Pro-endomorphin-1 / D-Pro-endomorphin-2 / DAMGO / μ opioid / 3-methoxynaltorexone |
|---|
| Research Abstract |
At least two mti-oploid receptor subtypes have been proposed; mul-and mu2-opioid rceptor subtypes. β-funaltrexamine irreversibly antagonizes both mul-and mu2-oploid receptors, whereas naloxonazine selectively antagonizes the mul-oplold receptor. However, the selective mu2-opioid antagonist has not yet been found. We found that D-Pro^2-endomorphin-1 selectively blocked the antinociceptive effect of i.t. administered DAMGO, as well as endomorphin-1, whereas antln6ciceptlon of Tyr-D-Arg-Phe-p-AJa, or endomorphin-2 was InhibIted by co-administration of D-Pro but not D-Pro Theses results indicate that these rwo D-Pro^2-endomorphins may be a useful tool to dlscrimate between the antinociceptive effects of mul-and mu2-oploid receptor agonists.
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