| Project/Area Number |
12680808
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Shinshu University |
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Principal Investigator |
MATSUMOTO Kiyoshi Shinshu University, Institute of Experimental Animals, Associate Professor, 医学部・動物実験施設, 助教授 (40173893)
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| Co-Investigator(Kenkyū-buntansha) |
TAGAWA Yoich Shinshu University, Institute of Experimental Animals, Lecturer, 医学部・動物実験施設, 講師 (70262079)
TAKAMOTO Masaya Shinshu University, Parasitology, Lecturer, 医学部・移植免疫感染症学講座, 講師 (90226928)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2002: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Eosinophil / Eosinophilia / Immunodeficiency / Rat / Parasitosis / Model animal / ConA肝炎 |
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| Research Abstract |
From our research, following results are obtained.
1) A quite new strain of spontaneous eosinophilic rat (Matsumoto Eosinophilia shinshu rats: MES/sdi) was produced.
2) All animals (more than 1500 rats tested) develop eosinophilia and bone marrow cell proliferation also observed.
3) From the results of anti-IL-5 study, it is suggested that IL-5 plays an important roles in pathogenesis of eosinophilia.
4) Histopathologically, eosinophilic proliferation and infiltration in the bone marrow, gastrointestinal tract, mesenteric lymph node, and spleen was found.
5) MES rats were resistant to infection with T. spiralis newborn larvae. This indicates that eosinophils destroy the newborn larvae in vivo.
From these results, it is concluded that MES rats could be a useful animal model for research on HES (Hypereosinophilic syndrome in humans) because the hypereosinophilia, with many associated eosinophilic lesions seen in the MES rats, is comparable to the features of HES in humans and other animals.
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