| Project/Area Number |
12680853
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Department of Biomedical Engineering Faculty of Engineering Osaka Electro-Communication University (2002)
Suzuka University of Medical Science (2000-2001) |
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Principal Investigator |
NAGAKURA Toshiaki Osaka Electro-Communication University, Biomedical Engineering, Professor, 工学部, 教授 (40288577)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Rika Suzuka University of Medical Science, Medical Electronics, Associate, 応用工学部, 助手 (50288578)
YOSHINO Seiji Suzuka University of Medical Science, Medical Electronics, Associate Professor, 応用工学部, 助教授 (90024596)
SAITO Kouji Suzuka University of Medical Science, Medical Electronics, Professor, 応用工学部, 教授 (00261040)
KUSUOKA Hideo Osaka University, Faculty of medicine, Professor, 医学部臨床, 教授
ISHIHARA Ken Ehime University Hospital, Medical Informatics, Professor, 医学部・医療情報部, 教授 (20304610)
桝田 晃司 愛媛大学, 医学部・医療情報部, 助手 (60283420)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2002: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2001: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2000: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Functional tissue characterization / Arteriosclerosis / Index / IMT / β / Multiple dimensions / 3D mode image / 4D mode image / 4Dモード |
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| Research Abstract |
It is for a purpose of this study to check in a non-invasive an arteriosclerosis before the morphologic change which I cannot detect in a conventional diagnostic method. We call this method a functional tissue characterization. By high speed ultrasound echography, we measure a change of cross-section area of a carotid artery, expansion speed in a resolution by a less wavelength of the ultrasound.
The measured continuous blood pressure in a tonometry method on an echo image simultaneously recorded. Analyzed how carotid artery transformed by blood pressure, it would be the diagnosis for arteriosclerosis, in other words it would be a non-invasive arteriosclerosis diagnosis system. From a change of this being viscoelasitc studies, we showed that functional behavior of an artery wall of a young was different from a senior. Furthermore, we developed 3D mode image which arranged time series of the carotid artery cross section which displayed the action of cross section of carotid artery. Furth
… More
ermore, we did development to the 4D mode image which displayed intuitively existence of an arteriosclerosis a color mapping of blood pressure information on the 3D mode image. By this method, it is possible to understand visually localizing arteriosclerosis more easily.
We examined comparison between our index and IMT (the thickness of a membrane complex of carotid artery wall) which is common index of arteriosclerosis, a and β index and which is standard index from a standpoint of elastic studies. From the result, as for all indexes, as for the index, increase tends by an aging, but there is a case to slip off in a senior greatly in β. IMT used commonly for evaluation of an arteriosclerosis is the superior index which is stable in a quantitative diagnosis of an arteriosclerosis currently. However, existence of an arteriosclerosis can be estimated, but it is only an average index of an arteriosclerosis. The greatest problems, it can not detect arteriosclerosis, If an arteriosclerosis does not progress, So it in not a sensitive to an arteriosclerosis in a young. However, our method can diagnose even young. Furthermore, our method have a visual and quantitative evaluation, it is possible to estimate, even if an arteriosclerosis is not average type. This method may be effective in n arteriosclerosis diagnosis for the artery does not have an morphologic change. Less
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