| Project/Area Number |
12794020
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| Research Category |
Grant-in-Aid for University and Society Collaboration
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Tohoku University |
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Principal Investigator |
KASAI Noriyuki Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (60001947)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Masatsugu YS New Technology Institute Inc., President and Research Director, 所長 主席研究員
OKAMURA Tadashi Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (00333790)
MIYOSHI Ichiro Graduate School of Medicine, Research Associate, 大学院・医学系研究科, 助手 (10183972)
HOCHI Shinichi Shinshu University, Faculty of Textile Science and technology, Associate Professor, 繊維学部, 助教授 (10283243)
HIRABAYASHI Masumi Okazaki National Research Institutes, National Institute for Physiological Science, Associate Professor, 生理学研究所, 助教授 (20353435)
高橋 一広 東北大学, 医学系研究科, 助手 (20292427)
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| Project Period (FY) |
2000 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥30,900,000 (Direct Cost: ¥30,900,000)
Fiscal Year 2002: ¥15,400,000 (Direct Cost: ¥15,400,000)
Fiscal Year 2001: ¥15,500,000 (Direct Cost: ¥15,500,000)
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| Keywords | Genetic manipulated mice / ICSY / Embryonic cryo-preservation / Regional supporting network system / Technology for embryonic manipulation / Cooperation with academic and industrial institutions / 遺伝子操作動物 / 卵巣凍結保存 / 発生工学技術支援 / 地域ネットワーク / 凍結精子 / 体外受精 |
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| Research Abstract |
The aim of this project is to establish the support network system for the technology of gene-alternated mice production and embryonic manipulation by closer cooperation with academic and industrial fields.
First we tried to develop the technology for embryonic manipulation of transgenic mice production and nuclear transfer. In this project we developed the ALS model rat, OGP transgenic mice and the prion assay system by human prion gene knock-in mice. In addition, we did basic research of technologies for rabbit embryo cryopreservation and ICASI technology for rat.
On the other hand, we suffered from MHV infection to most of mice in our institute. Therefore we countered by the closer cooperation with the companies for laboratory animal technology. In this incident, we verified the cooperation network system with our academic institution and industrial institutions.
By this project, we obtained the basic data for establishing the support network system for the technology of laboratory animals by closer cooperation with academic and industrial fields.
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