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パルス電解ストップドフロー分光法による酸素ラジカルの反応特異性の解明

Research Project

Project/Area Number 12875164
Research Category

Grant-in-Aid for Exploratory Research

Allocation TypeSingle-year Grants
Research Field 工業物理化学
Research InstitutionTokyo Institute of Technology

Principal Investigator

大坂 武男  東京工業大学, 大学院・総合理工学研究科, 教授 (80152099)

Co-Investigator(Kenkyū-buntansha) 岡島 武義  東京工業大学, 大学院・総合理工学研究科, 助手 (70194347)
北村 房男  東京工業大学, 大学院・総合理工学研究科, 助教授 (00224973)
徳田 耕一  東京工業大学, 大学院・総合理工学研究科, 教授 (40016548)
Project Period (FY) 2000 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords活性酸素 / 酸素ラジカル / ストップドフロー分光法 / スーパーオキシドイオン / 過酸化水素 / 酵素 / 酸素 / 電気化学 / 活性酸素種 / 電流振動現象 / アドアトム電極 / 電気化学センサ
Research Abstract

本研究は、様々な生命現象に密接に関連している活性酸素の電解生成、その場検出、反応制御、反応特異性の解明を目的として行われ、本年度は次の成果を得た。
1.非水溶媒中、吊り下げ水銀電極で電解生成したスーパーオキシドイオンおよび過酸化水素によって誘起される電流振動現象のメカニズムを解明し、新規な電気化学界面振動現象を明らかにした。
2.過酢酸と過酸化水素の電気化学的同時分析法を確立した。
3.アルカリ性水溶液中においてポリアニリン及びポリアニリンスルホン酸修飾電極を用いてスーパーオキシドイオンを電解生成できることを見出し、その生成機構を明らかにした。
4.自己組織化単分子膜電極を用いて、アスコルビン酸と神経伝達物質を同時分離・定量することに成功した。

Report

(2 results)
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • Research Products

    (50 results)

All Other

All Publications (50 results)

  • [Publications] M.S.SAHA: "Current Oscillation Behavior of O_2/O_2-Redox Couple at HMDE in Non-aqueous Aprotic Media"J. Electroanal. Chem.. 496・1〜2. 61-68 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.ARIHARA: "Characterization of the Adsorption State of Carboanate Ions at the Au(111) Electrode Sarface ..."J. Electroanal. Chem.. 510. 128-135 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.R.RAJ: "Electroanalysis of Ascorbate and Dopamine at Gold Electrode Modified with Positively Charged ..."J. Electroanal. Chem.. 496・1〜2. 44-49 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] N.WAKABAYASHI: "Effect of Adsorbed Anions on the Outer-Sphere Electron-Transfer Reactions of Cobalt Complexes ..."J. Electroanal. Chem.. 499. 161-168 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] F.MATSUMOTO: "Electrochemical Reduction of Molecular Oxygen at Hg Adatom-Modified Au Electrode"J. Electroanal. Chem.. 505. 150-158 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.I.AWAD: "Simultaneous Electroanalysis of Peroxyacetic Acid and Hydrogen Peroxide"Anal. Chem. 73・8. 1839-1843 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.R.RAJ: "Facilitated Electrochemical Oxidation of NADH and its Model Compound at Gold Electrode ..."Bioelectrochemistry. 53. 251-256 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.R.RAJ: "Electroanalytical Applications of Cationic Self-assembled Monolayers"Bioelectrochemistry. 53. 183-191 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 上杉慎治: "水銀アドアトム修飾電極上での過酸化水素の還元反応における電気化学振動現象"Electrochemistry. 69・9. 681-685 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.R.RAJ: "Simultaneous Electroanalysis of Ascorbic Acid, Dihydroxyphenylacetic Acid, Homovanilic Acid..."Chem. Lett. 670-671 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.S.AWAD: "Electroanalysis of Peracetic Acid in the Presence of a Large Excess of Hydrogen Peroxide"Anal. Lett.. 34・7. 1215-1221 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.R.RAJ: "Electrocatalytic Sensing of NADH at an in situ Functionalized self-assembled Monolayer on ..."Electrochem. Commun. 3. 633-638 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.R.RAJ: "Electrochemical and in situ FTIR Spectroscopic Investigation on the Electrochemical Transformation ..."Langmuir. 17. 7378-7386 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] H.ONO: "Electrogeneration of Superoxide Ion at Polyaniline-modified Electrodes in Aqueous Media"Electrochemistry. 69・12. 953-955 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.ARIHARA: "In situ Monitoring of the Mercury Electrode Surface in HClO_4 Solutions by Means of Infrared ..."J. Electroanal. Chem. 5/8. 139-143 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 大木成政: "アルカリ性水溶液中におけるポリアニリンスルホン酸修飾電極を用いたスーパーオキシドイオンの電解生成"Electrochemistry. 70・1. 23-29 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] C.R.RAJ: "Analytical Applications of Functionalized Self-assembled Monolayers on Gold Electrodes ..."Electroanalysis. (発表予定). (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.OHSAKA: "Superoxide Ion Sensor"Anal. Sci. (発表予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] L.MAO: "Electrochemical Characterization of Catalytic Activites of Manganese Oxides to Oxygen ..."J. Electrochem.. Soc. 149・4(発表予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.S.SAHA: "Interferometric Measurement of the Current Oscillation in the Redox Reaction of the O_2/O_2 ..."J. Phys. Chem. (発表予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Y.TIAN: "A Facilitated Electron-Transfer of Copper-Zinc Superoxide Disumutase (SOD) Based on a Cysteine ..."Biochem. Biophys. Acta. (発表予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.OKAJIMA: "Chemiluminescence of Indole and Its Derivatives Induced by Electrogenerated Superoxide Ion ..."Electrochem. Acta. (発表予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.S.El-DEAB: "An Extraordinary Electrocatalytic Reduction of Oxygen on Gold Nanoparticles-electrodeposited ..."Electrochem. Commun. 4(発表予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] D.ZHANG: "Electrochemical Reduction of Dioxygen on Mercury Electrode in Alkaline Aqueous Media"Jpn. J. Deuterium Sci.. (発表予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] 大坂武男(分担): "界面ハンドブック"エヌ・ティー・エス. 1208 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 大坂武男(分担): "電気化学測定マニュアル"丸善(株)(電気化学会編)(発表予定). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] S.A.John: "Alkanethiol Structure and Supporting Electrolyte Effects on the Electrochemical and in situ Fourier Transform…"Langmuir. 16. 876-880 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] C.R.Raj: "Electrocatalytic Oxidation of NADH at the Self-Assembled Monolayer of Ni(II) Macrocycle on Gold…"Bioelectrochemistry. 51. 181-186 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.V.Gobi: "Anion Recognition and Electrochemical Characteristics of the Self-Assembled Monolayer of Ni (II) Azamacro…"J.Electroanal.Chem.. 485. 61-70 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] J.F.Wu: "Electrochemical Uscillatory Phenomena in the O_2/O_2^- Redox Reaction on Hg-Coated Gold Electrode"Electrochemistry. 68. 277-279 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.A.John: "Can N-Ethyl-N'-Octadecyl Viologen Dimerize on Octadecane thiol-Coated Gold Electrode?"Electrochim.Acta. 45. 4041-4048 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] N.Nanbu: "Adsorption of Atomic Hydrogen on a Polycrystalline Pt Electrode Surface Studied by FT-IRAS"J.Electroanal.Chem.. 485. 128-134 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.S.Saha: "Electrochemical Oscillatory Phenomena Based on the Electrogenerated Superoxide Ion"Jpn.J.Deuterium Sci.. 9. 35-40 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大坂武男: "アドミッション・ポリシーの確立と明示を"化学と教育. 48. 342 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大坂武男: "分子修飾電極の速度論的解析および活性酸素種の反応制御への展開"Electrochemistry. 68. 608 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.A.John: "Structural Effects on the Electrochemical and Spectroelectrochemical Properties of Asymmetric…"J.Electroanal.Chem.. 492. 137-144 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.I.Awad: "Simultaneous Electroanalysis of Peracetic Acid and Hydrogen Peroxide Using Square-Wave Voltammetry"Electrochemistry. 68. 895-897 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Arihara: "Adsorption structure of the Heptyl Viologen Cation Radical on a Mercury Electrode Surface"J.Electroanal.Chem.. 488. 117-124 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] C.R.Raj: "Electroanalytical Applications of Cationic Self-Assembled Monolayers : Square-Wave Voltammetric…"Bioelectrochemistry. 52(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] F.Matsumoto: "Electrochemical Reduction of Molecular Oxygen at Hg Adatom-Modified Au Electrode"J.Electroanal.Chem.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] C.R.Raj: "Facilitated Electrochemical Oxidation of NADH and its Model Compound at Gold Electrode…"Bioelectrochemistry. 52(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.I.Awad: "Electroanalysis of Peracetic Acid in the Presence of a Large Excess of Hydrogen Peroxide"Anal.Lett.. 34(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.I.Awad: "Simultaneous Electroanalysis of Peroxyacetic Acid and Hydrogen Peroxide"Anal.Chem.. 73(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] N.Wakabayashi: "Effect of Adsorbed Anions on the Outer-sphere Electron Transfer Reactions of Cobalt Complexes at Platinium…"J.Electroanal.Chem.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] C.R.Raj: "Electroanalysis of Ascorbate and Dopamine at Gold Electrode Modified with Positively Charged SAM…"J.Electroanal.Chem.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.S.Saha: "Current Oscillation Behavior of O_2/O_2^-Redox Couple at HMDE in Non-Aqueous Aprotic Media"J.Electroanal.Chem.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大坂武男: "電位測定-参照電極・水溶液系-"Electrochemistry. 68. 610-614 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大坂武男(分担): "第5版電気化学便覧"丸善(株). 756 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Ohsaka(分担): "Precision Polymers and Nano-Organaized Systems"Kodansha Ltd.. 350 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 大坂武男(分担): "界面ハンドブック"(株)エヌ・ティー・エス(印刷中). (2001)

    • Related Report
      2000 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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