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Chemically modified STM tips for molecular imaging of DNA and cytochrome c

Research Project

Project/Area Number 13440219
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 分離・精製・検出法
Research InstitutionThe University of Tokyo

Principal Investigator

UMEZAWA Yoshio  The Universily of tokyo, Graduate Schoolof Science, Professor, 大学院・理学系研究科, 教授 (80011724)

Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥17,300,000 (Direct Cost: ¥17,300,000)
Fiscal Year 2002: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2001: ¥13,200,000 (Direct Cost: ¥13,200,000)
KeywordsSTM / DNA / carbon nanotube / SAM / surface analysis / chemically modified tips / Hydrogen bonding interaction / nucteotides / 化学的相互作用 / 科学修飾探針
Research Abstract

Cheniistry-iacilitated intermolecular electron tunneling is another approach to molecular imaging that is reported herein. The chemical imaging was obtained from a distinctive chemical affinity between the imaging tip of scanning tunneling microscopy (STM) and the substrate that afters the tunneling current. This was achieved by tailored chemical modification of the STM tips. When chemically modified tips are used for STM measurements, contrast enhancements at specific regions in STM images occur on the basis of hydrogen bond, charge-transfer, and metal-coordination interactions, and as a result, allowed to detect not only the distribution of specific chemical species and functional groups but also the orientation of functional groups. The contrast enhancements reflect the increase in a tunneling current due to the overlap of electronic wave functions induced by the chemical interactions between tip and sample. The molecular imaging of oligonucleotides was achieved therefrom.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Y.Umezawa, T.Ito: "Chemically Modified Scanning Tunneling Microscopy Tips for Molecular Imaging"Electrochemistry. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Nishino, T.Ito, Y.Umezawa: "Selective Observation of Hydroxy and Carboxylate Moieties by Scanning Tunneling Microscopy Using Chemically Modified Tips with Differing Extent of Hydrogen Bond Acidity or Basicity"Journal of Electroanalytical Chemistry. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y.Umezawa: "Seeing What Was Unseen. New Analytical Methods for Molecular Imaging"The Chemical Record. 3. 22-28 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Nishino, T.Ito, Y.Umezawa: "Carbon Nanotube Scanning Tunneling Microscopy Tips for Chemically Selective Imaging"Anal. Chem. 74. 4275-4278 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y. Umezawa, and T. Ito: "Chemically Modified Scanning Tunneling Microscopy Tips for Molecular Imaging"Electrochemistry. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T. Nishino, T. Ito, and Y. Umezawa: "Selective Observation of Hydroxy and Carboxylate Moieties by Scanning Tunneling Microscopy Using Chemically Modified Tips with Differing Extent of Hydrogen Bond Acidity or Basicity"Journal of Electroanalytical Chemistry. in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Y Umezawa: "Seeing What Was Unseen. New Analytical Methods for Molecular Imaging"The Chemical Record. 3. 22-28 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T. Nishino, T. Ito, and Y. Umezawa: "Carbon Nanotube Scanning Tunneling Microscopy Tips for Chemically Selective Imaging"Anal. Chem.. 74. 4275-4278 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Nishino, T.Ito, Y.Umezawa: "Carbon Nanotube STM Tips for Chemically Selective Imaging"Anal. Chem.. 74,No.16. 4275-4278 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Nishino, T.Ito, Y.Umezawa: "Selective Observation of Hydroxy and Carboxylate Moieties by Scanning Tunneling Microscopy Using Chemically Modified Tips with Differing Extent of Hydrogen Bond Acidity or Basicity"J. Electroanal. Chem.. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Ito, Y.Umezawa: "Chemically Modified Scanning Tunneling Microscopy Tips for Molecular Imaging"Electrochemistry. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Nishino, P.Buhlmann, T.Ito, Y.Umezawa: "Scanning tunneling microscopy with chemically modified tips : orientation-sensitive observation of ether oxygens"Surface Science. 490,No 1-2. L579-L584 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T, Nishino, P.Buhlmann, T.Ito, Y.Umezawa: "Discrimianation of Functional groups with Scanning Tuuneling Microscopy Using Chemically Modified Tips Recognition of Ether Oxygens Through Hydrogen Bond Interactions"Physical Chemistry Chemical Physics. 3. 1867-1869 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Ohshiro, T.Ito, P.Buhlmann, Y.Umezawa: "Scanning Tunneling Microscopy with Chemically Modified Tips : Discrimination of Porphyrin Centers Based on Metal Coordination and Hydrogen Bonc Interactions"Analytical Chemistry. 73,No 5. 878-883 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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