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A NOVEL SYNTHETIC ROUTE OF MOLECULARLY IMPRINTED POLYPYRROL FOR APPLICATION TO ELECTRONEUTRAL MOLECULES

Research Project

Project/Area Number 13440221
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 分離・精製・検出法
Research InstitutionYAMAGUCHI UNIVERSITY

Principal Investigator

NAGAOKA Tsutomu  YAMAGUCHI UNIVERSITY, DEPARTMENT OF APPLIED CHEMISTRY AND CHEMICAL ENGINEERING, PROFESSOR, 工学部, 教授 (00172510)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Masaharu  YAMAGUCHI UNIVERSITY, DEPARTMENT OF APPLIED CHEMISTRY AND CHEMICAL ENGINEERING, ASSOCIATE PROFESSOR, 工学部, 助教授 (70274181)
KAMIMURA Akio  YAMAGUCHI UNIVERSITY, DEPARTMENT OF APPLIED CHEMISTRY AND CHEMICAL ENGINEERING, ASSOCIATE PROFESSOR, 工学部, 助教授 (30194971)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥8,300,000 (Direct Cost: ¥8,300,000)
Fiscal Year 2002: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2001: ¥6,300,000 (Direct Cost: ¥6,300,000)
Keywordsoveroxidized polypyrrole / conducting polymer / molecular imprinting / amino acid / recognition of enantiomers / micelle / colloid / high selectivity / 導電性高分子 / 分子認識 / コール酸 / 過酸化ポリピロール / 光学異性体認識 / コレステロール / センサー / 高選択性
Research Abstract

Molecular imprinting techniques, which have developed during the last decade, are becoming a powerful tool for the preparation of artificial polymers that recognize target molecules. We have been applying the overoxidation technique for the preparation of polypyrrole (Ppy) films and colloids in order to evaluate the recognition performance of this technique. However, the main limitation of this approach has been the dopant charge, meaning that a template molecule must be anionic at least on polymerization.
To extend the possible range of target molecules, a technique using anionic analog templates has also been developed, and electroneutral or cationic molecules were successfully recognized with this technique. Another technique to remove the above limitation was also developed in this project. Attention was directed to a molecular recognition system with a cavity imprinted with a hydrophobic amino acid, which has been created in the hydrophobic core of a taurocholate anionic micelle doped in Ppy colloids. The important improvement of this technique is that an anionic (analog) template is no longer required. Further, the precisely formed shape-complementary cavities within the micelles gave a novel and straightforward synthetic route to highly effective enantiorecognition towards various amino acids.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report

Research Products

(22 results)

All Other

All Publications

  • [Publications] B.Deore, T.Nagaoka: "The direct electrochemical detection of amino acids at a Cu electrode in an acidic chromatographic effluent"Analytical Sciences. 17. i1691-i1694 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] U.Sree, Y.Yamamoto, B.Deore, H.Shiigi, T.Nagaoka: "Characterisaion of polypyrrole nano-films for membrane-based sensors"Synthetic Metals. 131. 161-165 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Okuno, T.Kitano, H.Yakabe, M.Kishimoto, B.A.Deore, H.Shiigi, T.Nagaoka: "Characterization of overoxidized Polypyrrole colloids imprinted with L-lactate and their application to enantioseparation of amino acids"Analytical Chemistry. 74. 4184-4190 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] B.Deore, H.Yakabe, H.Shiigi, T.Nagaoka: "Enantioselective uptake of amino acids using an electromodulated column packed with carbon fibres modified with overoxidised polypyrrole"Analyst. 127. 935-939 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Shiigi, K.Okamura, D.Kijima, A.Hionaka, B.Deore, U.Sree, T.Nagaoka: "Fabrication process and characterization of a novel structural isomer sensor. Molecularly imprinted overoxidized polypyrrole film"Electrochemical and Solid-State Letters. 6. H1-H3 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Shiigi, H.Yakabe, M.Kishimoto, D.Kijima, Y.Zhang, U.Sree, B.Deore, Tsutomu Nagaoka: "Molecularly Imprinted Overoxidized Polypyrrole Colloids : Promising Materials for Molecular Recognition"Microchimica Acta. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Deore, and T.Nagaoka: "The direct electrochemical detection of amino acids at a Cu electrode in an acidic chromatographic effluent"Analytical Sciences. 17. i1691-i1694 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] U.Sree, Y.Yamamoto, B.Deore, H.Shiigi, T.Nagaoka: "Characterization of polypyrrole nano-films for membrane-based sensors"Synthetic Metals. 131. 161-165 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Okuno, T.Kitano, H.Yakabe, M.Kishimoto, B.A.Deore, H.Shiigi and T.Nagaoka: "Characterization of overoxidized polypyrrole colloids imprinted with L-lactate and their application to enantioseparation of amino acids"Analytical Chemistry. 74. 4184-4190 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] B.Deore, H.Yakabe, H.Shiigi, and T.Nagaoka: "Enantioselective uptake of amino acids using an electromodulated column packed with carbon fibers modified with overoxidised polypyrrole"Analyst. 127. 935-939 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Shiigi, K.Okamura, D.Kijima, A.Hionaka, B.Deore, U.Sree, and T.Nagaoka: "Fabrication process and characterization of a novel structural isomer sensor. Molecularly imprinted overoxidized polypyrrole film"Electrochemical and Solid-State Letters. 6. H1-H3 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] H.Shiigi, H.Yakabe, M.Kishimoto, D.Kijima, Y.Zhang, U.Sree, B.Deore, and Tsutomu Nagaoka: "Molecularly Imprinted Overoxidized Polypyrrole Colloids : Promising Materials for Molecular Recognition"In press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] U.Sree, Y.Yamamoto, B.Deore, H.Shiigi, T.Nagaoka: "Characterisaion of polypyrrole nano-films for membrane-based sensors"Synthetic Metals. 131. 161-165 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] H.Okuno, T.Kitano, H.Yakabe, M.Kishimoto, B.A.Deore, H.Shiigi, T.Nagaoka: "Characterization of overoxidized polypyrrole colloids imprinted with L-lactate and their application to enantioseparation of amino acids"Analytical Chemistry. 74. 4184-4190 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] B.Deore, H.Yakabe, H.Shiigi, T.Nagaoka: "Enantioselective uptake of amino acids using an electromodulated column packed with carbon fibres modified with overoxidised polypyrrole"Analyst. 127. 935-939 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] H.Shiigi, K.Okamura, D.Kijima, A.Hionaka, B.Deore, U.Sree, T.Nagaoka: "Fabrication process and characterization of a novel structural isomer sensor. Molecularly imprinted overoxidized polypyrrole film"Electrochemical and Solid-State Letters. 6. H1-H3 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] H.Shiigi, H.Yakabe, M.Kishimoto, D.Kijima, Y.Zhang, U.Sree, B.Deore, Tsutomu Nagaoka: "Molecularly Imprinted Overoxidized Polypyrrole Colloids : Promising Materials for Molecular Recognition"Microchimica Acta. (印刷中).

    • Related Report
      2002 Annual Research Report
  • [Publications] H.Shiigi, M.Kishimoto, H.Yakabe, B.Deore, T.Nagaoka: "Highly Selective Molecularly Imprinted Overoxidized Polypyrrole Colloids : One-Step Preparation Technique"Anal.Sci.. 18. 41-44 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] B.Deore, T.Nagaoka: "Enantioselective Uptake of Amino Acids with Molecularly Imprinted Overoxidized Polypyrrole"Review of Polarography. 47. 76-86 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Z.Chen, K.Okamura, M.Hanaki, T.Nagaoka: "Selective Determination of Tryptophan by Using a Carbon Paste Electrode Modified with an Overoxidized Polypyrrole Film"Anal.Sci.. (印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] B.Deore, T.Nagaoka: "Chiral Discrimination of Amino Acids Using Polypyrrole and Its Overoxidized Form"Resarch Trends. (印刷中).

    • Related Report
      2001 Annual Research Report
  • [Publications] B.Deore, H.Shiigi, T.Nagaoka: "Triple Pulse Amperometric Detection of Underivatized Amino Acids at Polypyrrole Modified Copper Electrode in An Acidic Solution"Talanta. (印刷中).

    • Related Report
      2001 Annual Research Report

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Published: 2001-03-31   Modified: 2016-04-21  

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