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Study of Baylisascaris procyonis larva migrans : Pathological and parasitological analysis and development of serological diagnosis.

Research Project

Project/Area Number 13460137
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied veterinary science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

FURUOKA Hidefumi  OBIHIRO UNIVERSITY, ANIMAL HUSBANDRY, ASSOCIATE PROFESSOR, 畜産学部, 助教授 (60238665)

Co-Investigator(Kenkyū-buntansha) 赤尾 信明  東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (00126559)
KAMIYA Haruo  HIROSAKI UNIVERSITY, MEDICINE, PROFESSOR, 医学部, 教授 (70002079)
SATO Hiroshi  HIROSAKI UNIVERSITY, MEDICINE, ASSISTANT PROFESSOR, 医学部, 講師 (90211945)
松井 高峯  帯広畜産大学, 畜産学部, 教授 (40111116)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2001: ¥6,200,000 (Direct Cost: ¥6,200,000)
KeywordsBaylisascaria procyonis / Larva migrans / Serodiagnosis / Pathology / Parasitology / 病理 / 寄生虫 / 血清診断 / 感染実験 / 感染モデル / 血清疫学
Research Abstract

Larva migrans caused by the common raccoon ascarid, Baylisascaris procyonis, is a zoonotic disease of critical importance in North America. We encountered the first proven outbreak of this disease in Japan in domestic rabbits in a small wildlife park. In this park, raccoons had been kept for 9 years, and one raccoon was donated to the park by a pet owner 8 weeks prior to the occurrence of an outbreak in rabbits. Circumstantial evidence indicates that the donated raccoon is the likely source of this outbreak. Also, we investigated the details of the central nervous lesion in the rabbits affected with B.procyonis larva migrans in Japan. In this study, we demonstrated ascarid larvae in only eight out of 23 animals diagnosed as B.procyonis larva migrans. Since it is not always possible to detect the larvae, the possibility of B.procyonis larva migrans must be given serious consideration to the characteristic lesions. Also, B.procyonis causes a severe retinal lesion in humans. The lesion is termed as diffuse unilateral subacute neuroretinitis (DUSN). To understand the pathogenesis of B.procyonis in gerbils, we inoculated the embryonated eggs of B.procyonis into Mongolian gerbils, and monitored their fundi with an ophthalmoscope. Histopathological examination revealed perivasculitis in the optic disk region, inflammatory proliferation of the pigment cells, and vitreitis in most cases. These findings were similar to those in human cases of DUSN, suggesting that gerbils might be a useful model for understanding the pathogenesis of B.procyonis infection in humans.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Hiroshi Sato: "First outbreak of Baylisascaris procyonis larva migrans in rabbits in Japan."Parasitol Int. 51(1). 105-108 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nobuaki Akao: "Diffuse retinochoroiditis due to Baylisascaris procyonis in Monglian gerbils."J Parasitol. 89(1). 174-175 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiroshi Sato: "Epidemiological aspects of the first outbreak of Baylisascaris procyonis larva migrans in rabbits in Japan."J Vet Med Sci. 65(4). 453-457 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hidefumi Furuoka: "Neuropathological observation of rabbits (Oryctolagus cuniculus) affected with raccoon roundworm (Baylisascaris procyonis) larva migrans in Japan."J Vet Med Sci. 65(6). 695-699 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiroshi Sato: "Larva migrans by Baylisascaris transfuga : Fatal neurological diseases in Mongolian jirds, but not in mice."J Parasitol. 90(in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiroshi Sato: "First outbreak of Baylisascaris procyonis larva migrans in rabbits in Japan."Parasitol Int.. 51(1). 105-108 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nobuaki Akao: "Diffuse retinochoroiditis due to Baylisascaris procyonis in Monglian gerbils."J Parasitol.. 89(1). 174-175 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiroshi Sato: "Epidemiological aspects of the first outbreak of Baylisascaris procyonis larva migrans in rabbits in Japan."J Vet Med Sci.. 65(4). 453-457 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hidefumi Furuoka H: "Neuropathological observation of rabbits (Oryctolagus cuniculus) affected with raccoon roundworm (Baylisascaris procyonis) larva migrans in Japan."J Vet Med Sci.. 65(6). 695-699 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hiroshi Sato: "Larva migrans by Baylisascaris transfuga : Fatal neurological diseases in Mongolian jirds, but not in mice."J Parasitol.. 90(in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nobuaki Akao: "Diffuse retinochoroiditis due to Baylisascaris procyonis in Monglian gerbils"J Parasitol. 89(1). 174-175 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiroshi Sato: "Epidemiological aspects of the first outbreak of Baylisascaris procyonis larva migrans in rabbits in Japan"J Vet Med Sci. 65(4). 453-457 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hidefumi Furuoka: "Neuropathological observation of rabbits (Oryctolagus cuniculus) affected with raccoon roundworm Baylisascaris procyonis) larva migrans in Japan"J Vet Med Sci. 65(6). 695-699 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiroshi Sato: "Larva migrans by Baylisascaris transfuga : Fatal neurological diseases in Mongolian jirds, but not in mice"J Parasitol. 90(in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hiroshi Sato: "First outbreak of Baylisascaris procyonis larva migrans in rabbits in Japan"Parasitology International. 51・1. 105-108 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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