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Development of fluorescent x-ray detection technique in FXCT

Research Project

Project/Area Number 13470178
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionUniversity of Tsukuba

Principal Investigator

TAKEDA Tohoru  University of Tsukuba, Institute of Clinical Medicine, Assistant Professor, 臨床医学系, 講師 (10197311)

Co-Investigator(Kenkyū-buntansha) AKATSUKA Takao  Yamagata University, Faculty of Engineering, Professor, 工学部, 教授 (80091875)
ITAI Yuji  University of Tsukuba, Institute of Clinical Medicine, Professor, 臨床医学系, 教授 (30010268)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥16,400,000 (Direct Cost: ¥16,400,000)
Fiscal Year 2002: ¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 2001: ¥9,800,000 (Direct Cost: ¥9,800,000)
KeywordsFluorescent x-ray / Computed tomography / Specific element / in vivo imaging / Fluorescent x-ray detection
Research Abstract

Fluorescent x-ray technique is used to evaluate very low contents of specific elements in the order of picograms, however the measurement must be performed in the surfade of object. Then for in biological sample, the specimen is required to be cut into thin slices and scanned with a beam perpendicular to its surface. Fluorescent x-ray computed tomography (FXCT) have being developed to reveal the distribution of specific element in living state. By positioning the x-ray detector at 90° to the beam, the linear polarization of synchrotron x-rays helps to significantly reduce the Compton scattering overlapping the K_α line of specific elements. However, Compton scattering has increased markedly in large object, and highly purified germanium detector cannot measure the huge amounts of photon. To improve this problem, three experiments such as filter method, parallel collimator method and Laue-mirror method, were done to examine the reduction of Compton scattering from object.
Filter method, which is firstly thought most easy and highly effective method to reduce Compton scattering, is not useful because secondary fluorescent x-ray was generated by filter itself and this fluorescent x-ray overlaps on the iodine K_α line. Intense parallel collimator method, which reduces the efficacy of fluorescent x-ray detection, is most effective to reduce Compton scattering and to detect small amounts of fluorescent x-ray. Most ideal Laue-mirror method is difficult to set up the mirror system, so further improvement of x-ray mirror and its dedicate control is needed.
For in vivo FXCT imaging, collimator or Laue-mirror method appear to be an useful technique to reduce the huge amounts of Compton scattering from large object.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Quawen Yu: "Preliminary experiment of fluorescent x-ray computed tomography to detect dual agents for biomedical study"J. Synchrotron Radiation. 8. 1030-1034 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tsutomu Zeniya: "Integrated image presentation of transmission and fluorescent x-ray CT using Synchrotron radiation"Nuclear Instruments and Method in Physics Research. A467-468. 1326-1328 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tohoru Takeda: "Iodine imaging in thyroid by fluorescent x-ray CT with 0.05mm spatial resolution"Nuclear Instruments and Method in Physics Research. A467-468. 1318-1321 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tohoru Takeda: "Medical imaging by Fluorescent x-ray CT : Its preliminary clinical evaluation"SPIE. 4503. 299-309 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tohoru Takeda: "Biomedical X-ray imaging with fluorescent and interferometric phase contrast method"Proceedings of The 6^<th> World Multiconference on Systemics, Cybernetics and Informatics 2002. 7-22 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tohoru Takeda: "Biomedical imaging by fluorescent x-ray micro-computed tomography"Proceedings of Joint Symposium on Bio-Sensing and Bio-imaging 2001. 112-117 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tohoru Takeda: "Progress in Pathology Volume 5"Greenwich Medical Media Ltd. UK. 194 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yu Q, Takeda T, Yuasa T, Hasegawa Y, Jin W, Thet-Thet-Lwin, Hyodo K, Dilmanian FA, Itai Y, Akatsuka T: "Preliminary experiment of fluorescent x-ray computed tomography to detect dual agents for biomedical study"J.Synchrotron Radiation. 8. 1030-1034 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeda T, Yu Q, Yashiro T, Zeniya T, Wu J, Hasegawa Y, Thet-Thet-Lwin, Hyodo K, Yuasa T, Dilmanian FA, Akatsuka T, Itai Y: "Iodine imaging in thyroid by fluorescent x-ray CT with 0.05mm spatial resolution"Nuclear Instruments and Method in Physics Research A. 467-468. 1318-1321 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Zeniya T, Takeda T, Yu Q, Hasegawa Y, Hyodo K, Yuasa T, Hiranaka Y, Itai Y, Akatsuka T: "Integrated image presentation of transmission and fluorescent x-ray CT using synchrotron radiation"Nuclear Instruments and Method in Physics Research A. 467-468. 1326-1328 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeda T, Zeniya T, Wu J, Yu Q, Thet-Thet-Lwin, Tsushiya Y, D.V.Rao, Yuasa T, Yashiro T, Dilmanian FA, Itai Y, Akatsuka T: "Medical imaging by fluorescent x-ray CT : Its preliminary clinical evaluation"SPIE. 4503. 299-309 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeda T, Momose A, Wu J, Yu Q, Zeniya T, Thet-Thet-Lwin, Yoneyama A, Itai Y: "Vessel imaging by interferometric phase-contrast x-ray technique"Circulation. 105. 1708-1712 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeda T, Yoneyama A, Wu J, Zeniya T, Tsuchiya Y, Thet-Thet-Lwin, D.V.Rao, Matsushita S, Yuasa T, Yashiro T, Aiyoshi Y, Hyodo K, Hirano K, Momose A, Akatsuka T, Yuji Itai: "Biomedical X-ray imaging with fluorescent and interferometric phase contrast method"Proceedings of The 6th World Multiconference on Systemics, Cybernetics and Informatics 2002. 17-22 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] D.V.Rao, Takeda T, Itai Y, Akatsuka T, Cesareo R, Brunetti A, Gigante GE: "Doppler broadening and its contribution to compton energy-absorption cross sections : An analysis of the compton component in terms of mass-energy absorption coefficient"J.Phys.Chem.Ref.Data. 31. 769-818 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takeda T, Zeniya T, Wu J, Thet-Thet-Lwin, Yu Q, Tsuchiya Y, Yashiro T, Yuasa T, D.V.Rao, Hyodo K, Dilmanian FA, Itai Y, Akatsuka T: "Biomedical imaging by fluorescent x-ray micro-computed tomography"Proceedings of Joint Symposium on Bio-Sensmg and Bio-imaging 2001. 112-117 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yuasa T, Noto D, Takeda T, Zeniya T, Wu J, Thet-Thet-Lwin, Hiranaka Y, Itai Y, Akatsuka T: "Multispectral autoradiography using coded aperture with M-array"Proceedings of Joint Symposium on Bio-Sensing and Bio-imaging 2001. 300-303 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Tohoru Takeda: "Biomedical X-ray imaging with fluorescent and interferometric phase contrast method"Proceedings of The 6^<th> World Multiconference on Systemics, Cybernetics and Informatics 2002. 7-22 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] D.V.Rao: "Doppler broadening and its contribution to compton energy-absorption cross sections : An analysis of the compton component in terms of mass-energy absorption coefficient"J.Phys.Chem.Ref.Data. 31. 769-818 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tohoru Takeda: "Biomedical imaging by fluorescent x-ray micro-computed tomography"Proceedings of Joint Symposium on Bio-Sensing and Bio-imaging 2001. 112-117 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tetsuya Yuasa: "Multispectral autoradiography using coded aperture with M-array"Proceedings of Joint Symposium on Bio-Sensing and Bio-imaging 2001. 300-303 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 銭谷 勉: "脳機能画像放射光励起蛍光X線トモグラフィーの基礎的検討"信学技報. M2002-75. 35-40 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 武田 徹: "放射光・X線イメージング"Medical Imaging Technology. 20. 184-193 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tohoru Takeda: "Biomedical imaging by fluorescent x-ray micro-computed tomography"JSBB. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Quawen Yu: "Preliminary experiment of fluorescent x-ray computed tomography to detect dual agents for biomedical study"J.Synchrotron Radiation. 8. 1030-1034 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsutomu Zeniya: "Integrated image presentation of transmission and fluorescent x-ray CT using Synchrotron radiation"Nuclear Instruments and Method in Physics Research. A467-468. 1326-1328 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tohoru Takeda: "Iodine imaging in thyroid by fluorescent x-ray CT with 0.05mm spatial resolution"Nuclear Instruments and Method in Physics Research. A467-468. 1318-1321 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tohoru Takeda: "Medical imaging by Fluorescent x-ray XT:Its preliminary clinical evaluation"SPIE. 4503. 299-399 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 銭谷 勉: "放射光蛍光X線CTで得られる蛍光X線像とコンプトン散乱X線像の統合"信学技報. MI200-55. 31-36 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tohoru Takeda: "Progress in Pathology Volume 5"Greenwich Medical Media Ltd.UK. 194 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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