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Multinuclear localized spectroscopy at ultra-high field wholebody MRI

Research Project

Project/Area Number 13470192
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

MITSUMORI Fumiyuki  National Institute for Environmental Studies, Endocrine Disruptors & Dioxin Research Project, Leader, 環境ホルモン・ダイオキシン研究プロジェクト, 総合研究官 (90125229)

Co-Investigator(Kenkyū-buntansha) YAMANE Kazusuke  National Institute for Environmental Studies, Endocrine Disruptors & Dioxin Research Project, Senior Researcher, 環境ホルモン・ダイオキシン研究プロジェクト, 主任研究員 (40182589)
WATANABE Hidehiro  National Institute for Environmental Studies, Endocrine Disruptors & Dioxin Research Project, Senior Researcher, 環境ホルモン・ダイオキシン研究プロジェクト, 主任研究員 (60370269)
UMETSU Toyoshi  National Institute for Environmental Studies, Endocrine Disruptors & Dioxin Research Project, Senior Researcher, 環境ホルモン・ダイオキシン研究プロジェクト, 主任研究員 (00223610)
ITAI Yuji  University of Tsukuba, Department of Radiology, Professor, 臨床医学系, 教授 (30010268)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥11,800,000 (Direct Cost: ¥11,800,000)
Fiscal Year 2003: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 2002: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 2001: ¥7,000,000 (Direct Cost: ¥7,000,000)
Keywordsultra-high field MRI / multinuclear MRS / imaging / spectroscopy / triple-tuned rf coli / TEM型信号検出器
Research Abstract

We implemented three channels of transmitter and four channels of receiver to the 4.7T MRI spectrometer To enable triple nuclei measurements for ^1H, ^<31>P and ^<13>C, we constructed triple-tuned rf coils. First, we made a dual loop coil (8cm in diameter) for ^<31>P. Then, a single loop coil (12cm in diameter) was added up. These surface coils were integrated with a ^1H TEM coil for head (inner diameter of 30cm). This integrated probe was carefully tuned for three frequencies at 200.43, 81.14, and 50. 40MHz. Couplings among three frequencies were kept small enough. For the software to enable measurements in triple nuclei, we made a pulse sequence combining a ultra-short-echo time STEAM sequence for ^1H and an ISIS sequence for^<31>P This sequence enables us to measure ^1H and ^<31>P spectra from the same localized area in an interleave manner. For the localized spectroscopy for ^<13>C we added up a feature of ^<13>C editing to H localized spectrum. To attain the editing we added an inversion pulse for ^<13>C nucleus during the TM period of the STEAM sequence in alternative scans. TE for the STEAM was also adjusted to 7.7ms, which corresponds to 1/J_<CH> for sp_3-boded CH spins. With a triple tuned coil and a sequence for interleave measurements for ^1H, ^<31>P, and ^<13>C we tested performances of our method. ^1H, ^1H-detected ^<13>C, and ^<31>P spectra were successfully observed in the localized 2x2x2cm^3 area in the phantom sample containing 50 mM acetate, 50mM glutamate, and 100mM ATP. Then we applied the method to human brains. In the 3x3x3cm^3 area in the occipital lobe of human brain we could measure ^1H and ^<31>P spectra in ten minutes. We named this method as TRINITY after TRIple Nuclei In Triple channel spectroscopY.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] F.Mitsumori, M.Kumagai: "Pharmacological fMRI method for animal brain based on Mn2+-induced activity specific contrast"Proc.Soc.Magn.Reson.Med.. 9. 1328-1328 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Mitsumori: "fMRI method for animal brain based on Mn2+-induced activity-specific contrast"Proc.Int.Symp.Med.Imag.. 2002. 58-59 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 三森文行: "環境科学とin vivo NMR"分光研究. 51. 297-309 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Mitsumori, N.Takaya: "Interleave measurements of multinuclear spectra from the same localized area at 4.7Tesla wholebody MRI system"Proc.Soc.Magn.Reson.Med.. 11. 1138-1138 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 三森文行: "超高磁場人体用MRIにおける多核種同時計測法の開発に関する研究"インナービジョン. 18(8). 41-41 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Mitsumori, N.Takaya, H.Watanabe: "A method for interleave measurements of 1H, 1H-{13C}, and 31P spectra from the same localized area at 4.7T wholebody system"Proc.Soc.Magn.Reson.Med.. 12. 2461-2461 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 三森文行: "基礎から学ぶMRI"インナービジョン. 187 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Mitsumori, M.Kumagai: "Pharmacological fMRI method for animal brain based on Mn^<2+>-induced activity specific contrast."Proc.Soc.Magn.Reson.Med.. 9. 1328 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Mitsumori: "fMRI method for animal brain based on Mn^<2+>-induced activity-specific contrast."Proc.Int.Symp.Med.Imag.. 58-59 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Mitsumori: "Environmental Science and in vivo NMR (in Japanese)."Bunko Kenkyu. 51. 297-309 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Mitsumori, N.Takaya: "Interleave measurements of multinuclear spectra from the same localized area at 4.7Tesla wholebody MRI system."Proc.Soc.Magn.Reson.Med.. 11. 1138 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Mitsumori: "Multinuclear localized spectroscopy at ultra-high field wholebody MRI (in Japanese)."Innervision. 18(8). 41 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Mitsumori, N.Takaya, H.Watanabe: "A method for interleave measurements of ^1H, ^1H-{^<13>C}, and ^<31>P spectra from the same localized area at 4.7T wholebody system."Proc.Soc.Magn.Reson.Med.. 12. 2461 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] F.Mitsumori, N.Takaya: "Interleave measurements of multinuclear spectra from the same localized area at 4.7Tesla wholebody MRI system"Proc.Soc.Magn.Reson.Med.. 11. 1138-1138 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] F.Mitsumori, N.Takaya, H.Watanabe: "A method for interleave measurements of ^1H, ^1H-{^<13>C}, and ^<31>P spectra from the same localized area at 4.7T wholebody system"Proc.Soc.Magn.Reson.Med.. 12. 2461-2461 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 三森文行: "超高磁場人体用MRIにおける多核種同時計測法の開発に関する研究"インナービジョン. 18. 41-41 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 三森文行: "MRIの潜在力とその進化に期待する"新医療. 31. 40-42 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] 三森文行: "MRIの原理とハードウェア in「MRの最近の進歩と安全性」"日本磁気共鳴医学会. 97 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] F.Mitsumori: "fMRI method for animal brain based on Mn^<2+>-induced activity-specific contrast"Proc. Int. Symp. Med. Imag.. 2002. 58-59 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 三森文行: "環境科学とin vivo NMR"分光研究. 51(12). 297-309 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] F.Mitsumoti, M.Kumagai: "Proceedings of Nineth Annual Meeting of ISMRM."International Society for Magnetic Resonance in Medicine. 2351 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 三森文行: "基礎から学ぶMRI"インナービジョン. 187 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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