| Project/Area Number |
13470200
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | National Center of Neurology and Psychiatry |
|---|
Principal Investigator |
UCHIYAMA Makoto NATIONAL INSTITUTE OF NEUROSCIENE, NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY (NCNP), NATIONAL INSTITUTE OF MENTAL HEALTH, DEPARTMENT OF PSYCHOPHYSIOLOGY, DIRECTOR, 精神保健研究所, 部長 (20221111)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHINOHARA Kazuyuki NAGASAKI UNIVERSITY, GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, DEPARTMENT OF TRANSLATIONAL MEDICAL SCIENCES, PROFESSOR, 大学院・医歯薬学総合研究科・医療科学専攻, 教授 (30226154)
|
|---|
| Project Period (FY) |
2001 – 2003
|
| Project Status |
Completed (Fiscal Year 2003)
|
| Budget Amount *help |
¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2003: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2002: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2001: ¥4,900,000 (Direct Cost: ¥4,900,000)
|
|---|
| Keywords | SLEEP / SLEEPINESS / PREMENSTRUAL SYNDROME / OVARIAN STEROIDS / MELATONIN / SUPRACHIASMATIC NUCLEUS / CLOCK GENE / CIRCADIAN PACEMAKER |
|---|
| Research Abstract |
We previously reported a patient suffering from premenstrual syndrome in which sleep/wake and core body temperature rhythms displayed phase advances in the follicular phase and phase delays in the luteal phase. To see effects of ovarian steroid hormones on the circadian pacemaker, we conducted animal experiments and found that estrogen phase-advanced the circadian expression of Per2 gene in the suprachiasmatic nucleus but had no effects on that of Pen gene, suggesting that Per1 and Per2 genes in the suprachiasmatic nucleus were differentially regulated by estrogen. These results provide an explanation for phase advances in the follicular phase in premenstrual syndrome. Further analyses on molecular mechanisms of estrogen revealed that the phase advance of Per2 gene expression caused by estrogen was mainly regulated by interactions between SRC-1 and CLOCK in the suprachiasmatic nucleus. We applied an ultrashort sleep-wake schedule to eight healthy women and studied diurnal fluctuations in sleep propensity, sleepiness, rectal temperature, and serum concentrations of melatonin, thyroid-stimulating hormone, and cortisol in the follicular and luteal phases. In the luteal phase, amplitude of core body temperature, total melatonin secretions, and amplitudes of TSH and cortisol rhythms were significantly decreased, whereas sleepiness and occurrence of slow-wave sleep during the daytime were significantly increased. Differences in the amount of daytime slow-wave sleep across the menstrual cycle were positively correlated with differences in the daily mean rectal temperature. The findings suggest that the amplitude of circadian oscillation may be dampened in the luteal phase. Increased daytime sleepiness in the luteal phase may be associated with increased daytime slow-wave sleep, due possibly to changes in thermoregulation in the luteal phase.
|
