| Project/Area Number |
13470242
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
OGAWA Michio Kumamoto University, School of Medicine, Professor, 医学部, 教授 (30028691)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Masahiko Kumamoto University, School of Medicine, Lecturer, 医学部, 講師 (80284769)
EGAMI Hiroshi Kumamoto University, School of Medicine, Associate Professor, 医学部, 助教授 (00264284)
MORI Katsutaka Kumamoto University, College of Medical Science, Professor, 医療技術短期大学部, 教授 (10040213)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥12,900,000 (Direct Cost: ¥12,900,000)
Fiscal Year 2002: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2001: ¥8,100,000 (Direct Cost: ¥8,100,000)
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| Keywords | acute pancreatitis / CARS / cytokine antagonist / organ dysfunction / infection / cytokine / サイトカイン拮抗物質 / 遠隔臓器障害 / 重症急性膵炎 / SIRS / 敗血症 / 臓器障害 / 好中球 |
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| Research Abstract |
Acute pancreatitis is a potentially fatal disease. Most patients develop systemic inflammatory response syndrome (SIRS), which is induced by inflammatory cytokines. Alternatively, patients with severe inflammatory insults also undergo an anti-inflammatory phase, the compensatory anti-inflammatory response syndrome (CARS). This condition is characterized by the production of cytokine antagonists and, as a result, suppression of cytokine response, which may result in immune suppression. In this project, we analyzed acute pancreatitis from the viewpoints of CARS.
We elucidated the following points with this study, 1) In acute pancreatitis, abundant a mount cytokine antagonist is produced. 2) In the anaphase of the disease, de novo production of cytokines is suppressed by the cytokine antagonists. 3) Endotoxin can stimulate neutrophils accumulated in the distant organs to produce neutrophil elastase and reactive oxygen, and, as a result, provoke distant organ destruction without de novo cytokine production.
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