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Tumor sensitization to chemotherapy of radiation by artificial oxygen carriers

Research Project

Project/Area Number 13470244
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKEIO UNIVERSITY

Principal Investigator

KOBAYASHI Koichi  Keio Univ., School of Medicine, Professor, 医学部, 教授 (80051704)

Co-Investigator(Kenkyū-buntansha) WATANABE Masazumi  Keio Univ., School of Medicine, Instructor, 医学部, 助手 (90201227)
KAWAMURA Masafumi  Keio Univ., School of Medicine, Associate Professor, 医学部, 講師 (70169770)
HORINOUCHI Hirohisa  Keio Univ., School of Medicine, Associate Professor, 医学部, 講師 (60173647)
SHIGEMATSU Naoyuki  Keio Univ., School of Medicine, Associate Professor, 医学部, 講師 (30178868)
YAMAMOTO Manabu  Keio Univ., School of Medicine, Instructor, 医学部, 助手 (10317159)
山内 徳子  慶應義塾大学, 医学部, 助手 (30306732)
大塚 崇  慶應義塾大学, 医学部, 助手 (40306717)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 2002: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥9,500,000 (Direct Cost: ¥9,500,000)
Keywordsrat / tumor / Ly-80 / artificial oxygen carrier / chemotherapy / radiation / LK-80 / 腫瘍内酸素分圧 / 腫瘍循環 / 動脈内注入 / 補助科学療法
Research Abstract

Oxygenation of tumor tissue by intraarterial infusion of rHSA-FecycP : Tumor tissue oxygen tension started to use 5 minutes after the start of infusion, and remained elevated for 15 minutes. Based on this finding, since it takes at least 15 minutes to irradiate 20Gy using our irradiator, we decided to start irradiation and infusion simultaneously.
Combination of rHSA-FecycP, and chemotherapy : Cisplatin, 10mg/body, was administered followed, by intraarterial infusion of rHSA-FecycP. Early death occurred frequently by combination of cisplatin and rHSA-FecycP, presumably due to overt toxicity. This precluded further study.
Combination of rHSA-FecycP with radiation : Local tumor control was superior in the combination group compared with radiation alone. Survival was also significantly extended by combining rHSA-FecycP with radiation.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Iwamaru A, Kobayashi K, et al.: "Measurement of tumor blood flow using colored dye extraction microspheres in two rat tumor models"Int J Oncol. 18. 227-232 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kobayashi K, Watanabe M, et al.: "Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes"J Biomed Mater Res. 64. 48-51 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwamaru A, Kobayashi K, et al.: "Analysis of angiogenic profiles by estimation of tumor blood flow with colored dye extraction microspheres after antiangiogenic therapy"Oncol Rep. 10. 1127-1131 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwamaru A, Kobayashi K, et al.: "Measurement of tumor blood flow using colored dye extraction microspheres in two rat tumor models"Int J Oncol. 18. 227-232 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kobayashi K, Watanabe M., et al.: "Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes"J Biomed Mater Res. 64. 48-51 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Iwamaru A, Kobayashi K, et al.: "Analysis of angiogenin profiles by estimation of tumor blood flow with colored dye extraction microspheres after antiangiogenin therapy"Oncol Rep. 10. 1127-1131 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] A Iwamaru, K Kobayashi et al.: "Measurement of tumor blood flow using colored dye extraction microspheres in two rat tumor models"Int J Oncol. 18巻. 227-232 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] K kobayashi, M Watanabe et al.: "Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes"J Biomed Mater Res. 64巻. 48-51 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] A Iwamaru, K Kobayashi et al.: "Analysis of angiogenic profiles by estimation of tumor blood flow with colored dye extraction microspheres after antiangiogenic therapy"Oncol Rep. (in press).

    • Related Report
      2002 Annual Research Report
  • [Publications] A.Iwamaru, M.Watanabe, H.Horinouchi, K.Kobayashi: "Measurement of tumor blood flow using cotored dye extraction microspores in two rat tumor models"International Journal of Oncology. 18. 227-232 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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