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Basic and clinical research for perioperative management of braid-death donor and heart transplanted recipient

Research Project

Project/Area Number 13470320
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOsaka University

Principal Investigator

HAYASHI Yukiko  Osaka University, Faculty of Medicine, Associate professor, 医学系研究科, 助教授 (60294063)

Co-Investigator(Kenkyū-buntansha) KAMIBAYASHI Takahiko  Osaka University, Faculty of Medicine, Assistant professor, 医学系研究科, 助手 (10273640)
SHIBATA Masahiko  Osaka University, Faculty of Medicine, Assistant professor, 医学系研究科, 助手 (50216016)
MASHIMO Takashi  Osaka University, Faculty of Medicine, Professor, 医学系研究科, 教授 (60157188)
KOMAMURA Kazuo  Research Institute National Cardiovascular Center, Laboratory of Cardiac Dynamics, Head, 循環動態機能部, 室長
畔 政和  国立循環器病センター, 手術部, 部長(研究職)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥12,300,000 (Direct Cost: ¥12,300,000)
Fiscal Year 2003: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2002: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2001: ¥5,100,000 (Direct Cost: ¥5,100,000)
KeywordsBrain death / Heart transplantation / Arrhythmias / Central nervous system / Adrenomedullin / アドレメデュリン
Research Abstract

1)Establishment of brain death model (rats)
According to the method by Pratschke et al. (Transplantation 67 : 343-8, 1999) and some modifications, we have established the animal model of brain death. Our model can provide longer hemodynamic stability during and following induction of brain-death.
2)Myocardial sensitization of volatile anesthetics in brain-dead rats
Myocardial sensitizing effects of isoflurane and sevoflurane are less potent than that of halothane in brain-dead rats. However, both isoflurane and sevoflurane exert more potent myocardial sensitization in brain-dead rats compared with brain-dead rats without any volatile anesthetic.
3)Myocardial protection from arrhythmias with minimum hemodynamic instability
Nicorandil, an ATP sensitive potassium channel opener, exerts potent antiarrhythmic effect on halothane-epinephrine arrhythmias with small hemodynamic changes.
4)Central regulation of hemodynamics
Stimulation of Imidazohne receptor type 1 in the central nervous system provides antiarrhythmic effect on halothane-epinephrine arrhythmias in rats through activation of vagal nerve.
5)Adrenomedullin during nerioperative period of heart transplantation
Plasma level of adrenomedullin, a potent vasodilating peptide, dramatically increases following separation of cardiopulmonary bypass in patients undergoing heart transplantation compared with patients undergoing usual cardiac operations, suggesting that adrenomedullin maybe related with myocardial injury.
6)Monitoring of function of right heart during anesthetic management of heart transplantation
A pulmonary artery catheter, which can measure ejection fraction of right ventricle, is effective in anesthetic management of patients undergoing heart transplantation.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report

Research Products

(22 results)

All Other

All Publications

  • [Publications] 高山あかね, 林行雄, ほか: "心臓移植手術周術期管理におけるスワンガンツCCD/CEDVサーモダイリューションカテーテル^<【○!R】>の使用経験"循環制御. 23. 445-448 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawai K, Hayashi Y et al.: "Nicorandil prevents epinephrine-induced-arrhythmias in halothane anesthetized rats by nitric oxide dependent mechanism"Naunyn-Schmiedeberg's Archieves of Pharmacology. 366. 522-527 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitamura S, Nakatani T et al.: "Cardiac tranplantation under new legislation for organ transplantation in Japan : report of two cases"Jan Circ J. 64. 333-339 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 中谷武嗣, 笹子佳門ほか: "心不全治療のcardioprotection慢性期から急性期へ末期的心不全に対する外科的治療法としての左心補助人工心臓と心臓移植"心臓. 34. 54-57 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 中谷武嗣, 笹子佳門ほか: "【わが国の心臓移植の現況】国立循環器病センターでの経験。"今日の移植. 14. 418-424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 林 行雄: "臨床麻酔学全書"真興交易. 347-360 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 林 行雄, 真下 節: "麻酔科学スタンダードII"克誠堂. 337-346 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 林 行雄: "専門医のための麻酔科学レビュー2003"総合医学社. 177-180 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 林 行雄: "専門医のための麻酔科学レビュー2002"総合医学社. 177-180 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 林 行雄: "臓器移植麻酔マニュアル"真興交易. 126-140 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 林 行雄: "専門医のための麻酔科学レビュー2001"総合医学社. 180-184 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawai K, Hayashi Y, Ito I, Kamibayashi T, Takada K, Kagawa K, Yamatodani A, Mashimo T.: "Nicorandil prevents epinephrine-induced-arrhythmias in halothane anesthetized rats by nitric oxide dependent mechanism."Naunyn-Schlniedeberg's Achieves of Pharmacology. 366. 522-527 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitamura S, Nakatani T, Yagihara T, Sasako Y, Kobayashi J, Bando K, Minatoya K, Hanatani A, Komamura K, Imakita M, Yutani C, Kuro M, Kimura K, Nonogi H, Miyatake K.: "Cardiac transplantation under new legislation for organ transplantation in Japan: report of two cases."Jan Circ J. 64. 333-339 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takayama A, Hayashi Y, Yamano R, Iwasaki M, Kamibayashi T, Mashimo T.: "Utility of the Swan-Ganz CCO/CEDV thermodilution catherter <R○>^の during anesthetic management of heart transplantation.(In Japanese)"Circ Cont. 23. 445-448 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakatani T, Sasako Y, Hanatani A, Kobayashi J, Bando K, Ono Y, Nowata K, Tag sari O, Komamura K, Kimono K, Yagihara T, Miyatake K, Kitamura S.: "Cardiopretection for heart failure therapy. Surgical therapy for end-stage heart failure (Left ventricular assist device and heart transplantation)(In Japanese)"Heart. 34. 54-57 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakatani T, Sasako Y, Hanatani A, Kobayashi J, Bando K, Ono Y, Niwaya K, Tagusari O, Sato N, Komamura K, Kumon K, Yutani C, Yagihara T, Miyatake K, Kitamura S.: "Experience of cardiac transplantation at National Cardiovascular Center. (In Japanese)"Transplantation Today. 14. 418-424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 高山あかね, 林 行雄ほか: "心臓移植手術周術期管理におけるスワンガンツCCD/CEDVさーもだいりゅーしょんカテーテル^【○!R】の使用経験"循環制御. 23. 445-448 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawai K, Hayashi Y et al.: "Nicorandil Prevents epinephrine-induced-arrhythmias in halothane anesthetized rats by nitric oxide dependant mechanism"Naunyn-Schmiedeberge's Archieves of Pharmacology. 366. 522-527 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 林 行雄: "心臓移植の麻酔"臨床麻酔学全書。花岡和雄、真下 節、福田和彦(編集). 347-360 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] 林 行雄, 真下 節: "肺移植、心臓移植の麻酔"麻酔科学スタンダードII。小川節郎、新宮 興、武田純三、西野 卓(編集). 337-346 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 高山あかね, 林 行雄, ほか: "心臓移植手術周術期管理たおけるスワンガンツCCD/CEDVさーもだいりゅーしょんカテーテル^<【○!R】>の使用経験"循環制御. 23. 445-448 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawai K, Hayashi Y et al.: "Nicorandil prevents epinephrine-induced-arrhythmias in halothane anesthetized rats by nitric oxide dependent mechanism"Naunyn-Schmiedeberg's Archieves of Pharmacology. 366. 522-527 (2002)

    • Related Report
      2002 Annual Research Report

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Published: 2001-03-31   Modified: 2016-04-21  

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