| Project/Area Number |
13470372
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Fujita Health University |
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Principal Investigator |
HORIGUCHI Masayuki Fujita Health University, School of Medicine, Professor, 医学部, 教授 (70209295)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAKE Yozo Nagoya university, School of Nedicine, Professor, 医学部, 教授 (30166136)
SHIMADA Yashiaki Fujita Health University, School of Medicine, Lecturer, 医学部, 講師 (90261908)
小嶋 義久 藤田保健衛生大学, 医学部, 助手 (30340235)
重光 利朗 藤田保健衛生大学, 医学部, 講師 (50215969)
鈴木 宏光 藤田保健衛生大学, 医学部, 助手
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥8,900,000 (Direct Cost: ¥8,900,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥6,200,000 (Direct Cost: ¥6,200,000)
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| Keywords | Diabetic retinopathy / ERG / focalERG / Multifocal ERG / Blue cone / Silent substitution / Stray light / Second order lernel / 青錐体網膜電図 / 中長波長錐体網膜電図 / 全視野刺激網膜電図 / 加齢黄斑変性 / 網膜色素変性症 / 散乱光 / 反射光 / 一次核 / 二次核 / 赤緑錐体 / 黄斑 / 黄斑疾患 |
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| Research Abstract |
Diabetic retinopathy can be accurately diagnosed by fluorescein angiogram(FA). However, FA cannot be frequently repeated. Electroretinogram may be a useful tool for diagnosis of diabetic retinopathy. Since the diabetic change starts from local area of the ocular fundus and its severity varies from area to area, full-field ERG is not suited for study of diabetic retinopathy. Focal ERG is needed. Multifocal ERG(mfERG) can record focal ERG from many areas of the fundus simultaneously and is suited for diagnosis of diabetic retinopathy. We studied patients with diabetic retinopathy using blue cone mfERG that is recorded by silent substitution of color ORT monitor. Blue cone System is more vulnerable than red and green cone systems. Blue cone focal ERG (first order kernel), was abnormal in the area without visible abnormality of the retina, indicating that it is very sensitive to diabetic change. However, our study revealed that white lesions, such as hard or soft exudates, causes stray light effect on the focal responses. Our experiments also showed that the second order kernel is free from stray light effect. Therefore, we tried to extract the second order kernel of blue cone mfERG but were not successful because of its small amplitude. Our conclusion in this study is that the first order kernel of blue cone mfERG is very sensitive to diabetic change but is affected by white lesions, and the second order kernel of blue cone mfERG should be investigated.
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