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Control of interface between tooth tissue and resin by amino acid derivative

Research Project

Project/Area Number 13470412
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field 補綴理工系歯学
Research InstitutionOKAYAMA UNIVERSITY

Principal Investigator

SUZUKI Kazuomi  Okayama Univ., Graduate School of Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授 (30050058)

Co-Investigator(Kenkyū-buntansha) TANAKA Jiro  Okayama Univ., Graduate School of Medicine and Dentistry, Assistant Prof., 大学院・医歯学総合研究科, 助手 (40171764)
IRIE Masao  Okayama Univ., Graduate School of Medicine and Dentistry, Assistant Prof., 大学院・医歯学総合研究科, 助手 (90105594)
YOSHIDA Yasuhiro  Okayama Univ., Graduate School of Medicine and Dentistry, Associate Prof., 大学院・医歯学総合研究科, 助教授 (90281162)
NISHIYAMA Norihiro  Nihon Univ., School of Dentistry at Matsudo, Associate Prof., 松戸歯学部, 助教授 (90112953)
矢谷 博文  岡山大学, 大学院・医歯学総合研究科, 教授 (80174530)
石川 邦夫  九州大学, 大学院・歯学研究院, 教授 (90202952)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥16,200,000 (Direct Cost: ¥16,200,000)
Fiscal Year 2003: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2002: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2001: ¥12,500,000 (Direct Cost: ¥12,500,000)
KeywordsTooth / Adhesion / Composite resin / Surface treatment / Collagen / Apatite / Hybrid / Functional monomer
Research Abstract

The bonding technique to tooth tissue including etching procedure and adhesive application was developed to get functional reconstruction of the caries in a wide area application. However, it is difficult to make a perfect bonding, a good characteristic of marginal gap closure, bonding strength and durability under a severe condition of buccal cavity. The main problem is on the formation and the physical properties of the interface layer between tooth tissue and resin. Therefore, we synthesize the amino acid derivative (NMωA) which has chemical compound affinity, especially by examining the interaction with dentinal collagen. In this study, in order to specify the NMωA formed by the interaction of collagen functional group, the relaxation time of NMωA in the collagen model chemical, compound that has an end part of imino unit and carboxyl unit was measured.
The measurement of ^<13>CNMR (T_1) is as follows. Oligopeptide of 10% (5 bodies of prolylprolylglycine, unit of protein/amino acid) … More were dissolved in hydrochloric acid added deuterium oxide aqueous solution. The aqueous solution was manufactured at the pH of 1.7. After homogenized, 0.6g of this oligopeptide aqueous solution was placed in the NMR sample tube. 6.73×105 or 20.19 x 10^5 mol of NMωA was used as the NMR sample. T_1 was measured using an EX270MHz spectrometer (Nihon Denshi), which is performed with 180゜-τ-90゜ pulse sequence, in the temperature of 25℃.
As oligopeptides were coexist in NMωA aqueous solution, in order to examine an interaction of amide unit and carbonyl unit in the molecule of NMωA with the oligopeptide, the value of T_1 of carbonyl carbon which revert to these functional groups was similar to that was coexists in the deashing dentine. Compared to that of the non-coexistence chain, there was a great decrease. From the above result, the presents of amide and carboxyl unit in the molecule of NMωA showed that the side chains functional group of carbonyl unit and hydrogen bond in the collagen are formed. Furthermore, in case of hydroxymethacrylate (HEMA), it was identified that there was a strong interaction between the carbonyl unit in the same peptide and the carbonyl unit in the molecule. Less

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Itou K., et al.: "Effect of priming time on tensile bond strength to bovine teeth and morphologic structure of interfaces by self-etching primers"The International Journal of Prosthodontics. 14. 225-230 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka L., et al.: "Polymer properties on resins composed of UDMA and methacrylates with the carboxyl group"Dental Materials Journal. 20. 206-215 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishiyama N., et al.: "A ^<13>C NMR study on the adsorption characteristics of HEMA to dentinal collagen"Journal of Dental Research. 81. 469-471 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakabo S., et al.: "Regulation of NaF release from bis-GMA/TEGDMA resin using γ-methacryloxypropyltrimethoxysilane"Dental Materials. 18. 81-87 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Irie M., et al.: "Effect of delayed polishing periods on interfacial gap formation of Class V restorations"Operative Dentistry. 28. 552-559 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tjandrawinata R., et al.: "Effect of adding spherical silica filler on physicomechanical properties of resin modified glass-ionomer cement"Dental Materials Journal. (In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Itou K.: "Effect of priming time on tensile bond strength to bovine teeth and morphologic structure of interfaces created by self-etching primers"The International Journal of Prosthodontics. 14. 225-230 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanaka J.: "Polymer properties on resins composed of UDMA and methacrylates with the carboxyl group"Dental Materials Journal. 20(3). 206-215 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakabo S.: "Effects of polysiloxane coating of NaF on the release profile of fluoride ion from bis-GMA/TEGDMA resin containing NaF"Dental Materials Journal. 20(1). 53-62 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Irie M.: "Current luting cements : marginal gap formation of composite inlay and their mechanical properties"Dental Materials. 17(4). 347-353 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishiyama N.: "A ^<13>C NMR study on the adsorption characteristics of HEMA to dentinal collagen"Journal of Dental Research. 81(7). 469-471 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakabo S.: "Effects of fluoride release from bis-GMA/TEGDMA resin regulated by γ-methacryloxypropyltrimethoxysilane on demineralization of bovine enamel"Biomaterials. 23(16). 3503-3508 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakabo S.: "Regulation of NaF release from bis-GMA/TEGDMA resin using γ-methacryloxypropyltrimethoxysilane"Dental Materials. 18(1). 81-87 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Irie M.: "Effects of delayed polishing on gap formation of cervical restorations"Operative Dentistry. 27(1). 59-65 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Irie M.: "Marginal gap formation of light-activated restorative materials : effects of immediate setting shrinkage and bond strength"Dental Materials. 18(3). 203-210 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Torii Y.: "Effect of self-etching primer containing N-acryloyl aspartic acid on enamel adhesion"Dental Materials. 19(4). 253-258 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Irie M.: "Effect of delayed polishing periods on interfacial gap formation of Class V restorations"Operative Dentistry. 28(5). 552-559 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tjandrawinata R.: "Effect of adding spherical silica filler on physico-mechanical properties of resin modified glass-ionomer cement"Dental Materials Journal. (In press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] S.Nakabo et al.: "Effects of fluoride release from bis-GMA/TEGDMA resin regulated by γ-methacryloxypropyltrimethoxysilane on demineralization of bovine enamel"Biomaterials. 23・16. 3503-3508 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Nishiyama et al.: "Dissociation states of the collagen functional group and the effects on the priming efficacy of HEMA to Collagen"Journal of Dental Research. 82・4. 257-261 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Nishiyama et al.: "The pKa effects of the carboxylic acid in N-methacryloyl-omega-amino acid on the demineralization and bond strengths to the teeth"Biomaterials. (in press).

    • Related Report
      2003 Annual Research Report
  • [Publications] N.Nishiyama et al.: "A ^<13>C NMR Study on the Adsorption Characteristics of HEMA to Dentinal Collagen"Journal of Dental Research. 81・7. 469-471 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] N.Nishiyama et al.: "Adhesion N-Methacryloyl-ω-Amino Acid Primers to Collagen Analyzed by ^<13>C NMR"Journal of Dental Research. 80・3. 855-859 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] K.Itou et al.: "Effect of Priming Time on Tensile Bond Strength to Bovine Teeth and Morphologic Structure of Interfaces Created by Self-Etching Primers"International Journal of Prosthodontics. 14・3. 225-230 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Irie et al.: "Current luting cements : marginal gap formation of composite inlay and their mechanical properties"Dental Materials. 17・4. 347-353 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] J.Tanaka et al.: "Polymer Properties on Resins Composed of UDMA and Methacrylates with the Carboxyl Group"Dental Material Journal. 20・3. 206-215 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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