Intervention-studies in weight control and skeletal muscle characteristics with food restriction and exercise

• Project/Area Number: 13480009
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 体育学
• Research Institution: KYUSHU UNIVERSITY
• Principal Investigator: KUMAGAI Shuzo Institute of Health Science, Ass. Prof., 健康科学センター, 助教授 (80145193)
• Co-Investigator(Kenkyū-buntansha): NAKANO Hiroshi Department of Human Development, Nakamura Gakuen University, Assist. Prof., 人間発達学部, 講師 (60301678) ; HIGAKI Yasuki Department of Preventive Medicine, Saga Medical School, Assist. Prof., 予防医学, 講師 (10228702) ; KATSURA Shigeru Graduate School of Integrated Science and Art, University of East Asia, Prof., 大学院・総合学術研究科, 教授 (70038446) ; ITO Tatsumi Faculty of Agriculture, Prof., 大学院・農学研究院, 教授 (50038246)
• Project Period (FY): 2001 – 2002
• Project Status: Completed (Fiscal Year 2002)
• Budget Amount: ¥2,200,000 (Direct Cost: ¥2,200,000); Fiscal Year 2002: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: abdominal fat / food restriction / high fat diet / leptin / obesity / oxidative enzyme / skeletal muscle characteristics / weight reduction / 筋繊維組成 / 速筋繊維優位ラット / インスリン感受性 / インスリン抵抗性 / エネルギー代謝 / 酵素活性 / 自発的活動量

Research Abstract

Skeletal muscle plays an important role in energy metabolism. Therefore, its characteristics have been studied in numerous experiments on obesity as well as diabetes to investigate their contribution. According to the clinical and experimental data mainly obtained from cross-sectional studies, fiber composition, capillarization, enzyme activities in the muscle were considered to be involved in the possible pathogenesis of obesity. However, without interventions, all of these cross-sectional studies were inadequate to clarify any of these hypotheses. Longitudinal studies provided the possibility to reveal the causality between skeletal muscle characteristics and obesity. We carried out studies based on a precise study protocol. In these studies, skeletal muscle adaptation to diet-induced weight control is being investigated in rats. Visceral adipose was chosen to be the classificatory criterion. Energy intake is not significantly different. Muscle samples are collected from the same portion of the same muscle before and after the diet periods. Results which may contribute to the knowledge of obesity/lean-susceptibility are expected.

Research Products

• [Publications] Zou B.et al.: "Overview of skeletal muscle adaptation to diet-induced weight control"Jpn J Health Prom Sci. 5・1. 1-13 (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Zou B.et al.: "Adaptation in skeletal muscle characteristics to a high-fat diet in rats with different intra-abdominal-obesity susceptibilities"J Nutr Sci Vitaminol. 49・4(accepted for publication). (2003)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Zou B. et al.: "Overview of muscle adaptation to diet-induced weight control"Jpn J Health Prom Sci. 5-1. 1-13 (2003)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Zou B. et al.: "Adaptation in skeletal muscle characteristics to a high-fat diet in rats with different intra-abdominal-obesity susceptibilities"J Nutr Sci Vitaminol. accepted for publication.
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Zou B, Suwa M, Kumagai S: "Overview of skeletal muscle adaptation to diet-induced weight control"Jpn J Health Prom Sci. 5・1. 1-13 (2003)