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Molecular basis of signaling network involved in biological clock and circadian rhythms in higher plants

Research Project

Project/Area Number 13480226
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Molecular biology
Research InstitutionNagoya University

Principal Investigator

MIZUNO Takeshi  Nagoya University, Dep.Agricultural Bioscience, Professor, 大学院・生命農学研究科, 教授 (10174038)

Co-Investigator(Kenkyū-buntansha) YAMADA Hisami  Nagoya University, Dep.Agricultural Bioscience, Assistant Professor, 大学院・生命農学研究科, 助手 (30089859)
AIBA Hirofumi  Nagoya University, Dep.Agricultural Bioscience, Associate Professor, 大学院・生命農学研究科, 助教授 (60211687)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2003: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2002: ¥4,400,000 (Direct Cost: ¥4,400,000)
Fiscal Year 2001: ¥5,500,000 (Direct Cost: ¥5,500,000)
KeywordsBiological clock / Higher Plants / Arabidopsis thaliana / Circadian Rhythms / APRR Quintent / Photomornhogenesis / Control of Flowering Time / 情報伝達 / 形質転換植物
Research Abstract

Circadian rhythms are driven by an endogenous biological clock(s) that regulates many biochemical, physiological and behavioral processes in a wide variety of organisms. In higher plants too, there are a wide range of biological processes that are controlled through the circadian clock In these respects, recent intensive studies on the model plant Arabidopsis thaliana have begun to shed light on the molecular mechanisms underlying these circadian-controlled biological events. In Arabidopsis thaliana, a number of circadian-associated factors have been identified. Among those, TOC1 is believed to be a component of the central oscillator. TOC1 is a member of a small family of proteins, designated as ARABIDOPSIS PSEUDO-RESPONSE REGULATORS (APRR1/TOC1, APRR3, APRR5, APRR7, and APRR9). Nonetheless, it is not very clear whether or not the APRR family members other than APRR1(TOC1 are also implicated in the mechanisms underlying the circadian rhythm. To address this issue further, here we characterized a set of T-DNA insertion mutants, each of which is assumed to have a severe lesion in each one of the quintet genes. We found that a given mutation singly, if not directly, affects the circadian-associated biological events simultaneously : (i) the flowering time in the long-day photopertod conditions, and (ii) the red light sensitivity of seedlings during the early photomorphogenesis, (iii) the period of free-wnning rhythms of certain clock-controlled genes including CCA1 and APRR1/TOC1 in constant white light. These results suggest that, although the quintet members other than APRR1/TOC1 may not be directly integrated into the framework of the central oscillator, they are crucial for a better understanding of the molecular mechanisms underlying the Arabidopsis circadian clock.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] Nakamichi, N. その他: "Cell autonomous circadian waves of the APRR1/TOC1 quintet in an established cell line of Arabidopsis thaliana."Plant Cell Physiol.. 44. 360-365 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamashino, T.その他: "A link between circadian-controlled bHLH factors and APRR1/TOCI quintet in Arabidopsis thaliana."Plant Cell Physiol.. 44. 619-629 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mumkami, M.: "The evolutionary conserved OsPRR quintet : rice pseudo-response regulators implicated in circadian rhythm."Plant Cell Physiol.. 44. 1229-1236 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ito, S.その他: "Characterization of the APRR9 pseudo-response regulator belonging to the APRR1/TOC1 quintet in Arabidopsis thaliana."Plant Cell Physiol.. 44. 1237-1245 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, Y.その他: "Comparative genetic studies on the APRR5 and APRR7 genes belonging to the APRR1/TOC1 quintet implicated in circadian rhythm, control of flowering, and early photomorphogenesis."Plant Cell Physiol.. 44. 1119-1130 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] 杉山達夫, 水野 猛, 他 編: "植物の代謝コミュニケーション"共立出版. 260 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Makino, S., Matsushika, A., Kojima, M., Oda, Y., Mizuno, T.: "Light response of the circadian waves of the APRR1/TOC1 uintet : When does the quintet start singing rhythmically in Arabidopsis thaliana"Plant Cell Physiol.. 42. 334-339 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Makino, S., Matsushika, A., Kojima, M., Yamashino, T., Mizuno, T.: "The APRR1/TOC1 quintet implicated in circadian rhythms of Arabidopsis thaliana : I. Characterization with APRR1-overexpressing plants."Plant Cell Physiol. 43. 58-69 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsushika, A., Makino, S., Kojima, M., Yamashino, T., Mizuno, T.: "The APRR1/TOC1 quintet implicated in circadian rhythms of Arabidopsis thaliana : II. Characterization with CCA1-overexpressing plants."Plant Cell Physiol.. 43. 118-122 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murakami-Kojima, M., Nakamichi, N., Yamashino, T., Mizuno, T.: "The APRR3 component of the dock-associated APRR1/TOC1 quintet is phosphorylated by a novel protein kinase belonging to the WNK family, the gene for which is also transcribed rhythmically in Arabidopsis thaliana."Plant Cell Physiol.. 43. 675-683 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Matsushika, A., Imamura, A., Yamashino, T.Mizuno, T.: "Aberrant expression of the light-inducible and circadian-regulated APRR9 gene belonging to the circadian-associated APRR1/IOC1 quintet results in the phenotype of early flowering in Arabidopsis thaliana."Plant Cell Physiol.. 43. 833-843 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sato, E., Nakamichi, N., Yamashino, T., Mizuno, T.: "Aberrant expression of the Arabidopsis circadian-regulated APRR5 gene belonging to the APRRI/TOC1 quintet results in early flowering and hypersensitiveness to light in early photomorphogenesis."Plant Cell Physiol. 43. 1374-1385 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakamichi, N., Matsushika, A., Yamashino, T.Mizuno, T.: "Cell autonomous circadian waves of the APRR1/TOC1 quintet in an established cell line of Arabidopsis thaliana"Plant Cell Physiol.. 44. 360-365 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamashino, T., Matsushika, A., Fujimari, T., Sato, S., Kato, T., Tabata, S., Mizuno, T.: "A link between circadian-controlled bHLH factors and the APRR/TOC1 quintet in Arabidopsis thaliana."Plant Cell Physiol.. 44. 619-629 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murakami, M., Ashikari, M., Miura., K., Yamashino, T., Mizuno, T.: "The evolutionary conserved OsPRR quintet : rice pseudo-response regulators implicated in circadian rhythm."Plant Cell Physiol.. 44. 1229-1236 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ito, S., Matsushika, A., Yamada, H., Sato, S., Kato, T., Tabata, S., Yamashino, T., Mizuno, T.: "Characterization of the APRR9 pseudo-response regulator belonging to the APRR1/TOC1 quintet in Arabidopsis thaliana."Plant Cell Physiol.. 44. 1237-1245 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, Y., Sato, E., Shimizu, T., Nakamichi, N., Sato, S., Kato, T., Tabata, S., Nagatani, A., Yamashino, T., Mizuno, T.: "Comparative genetic studies on the APRR5 and APRR7 genes belonging to the APRR1/TOC1 quintet implicated in circadian rhythm, control of flowering time, and early photomorphogenesis."Plant Cell Physiol.. 44. 1119-1130 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakamichi, N.その他: "Cell autonomous circadian waves of the APRR1/TOC1 quintet in an established cell line of Arabidopsis thaliana"Plant Cell Physiol. 44. 360-365 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamashino, T.その他: "A link between circadian-controlled bHLH factors and the APRR1/TOC1 quintet in Arabidopsis thaliana"Plant Cell Physiol.. 44. 619-629 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Murakami, M.その他: "The evolutionary conserved OsPRR quintet : rice pseudo-response regulators implicated in circadian rhythm"Plant Cell Physiol.. 44. 1229-1236 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ito, S.その他: "Characterization of the APRR9 pseudo-response regulator belonging to the APRR1/TOC1 quintet in Arabidopsis thaliana"Plant Cell Physiol.. 44. 1237-1245 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamamot, Y.その他: "Comparative genetic studies on the APRR5 and APRR7 genes belonging to the APRR1/TOC1 quintet implicated in circadian rhythm, control of flowering, and early photomorphogenesis"Plant Cell Physiol.. 44. 1119-1130 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 杉山達夫, 水野 猛, 長谷俊治, 斉藤和季 編: "植物の代謝コミュニケーション"共立出版. 260 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsushika, A. et al.: "The APRR1/TOC1 quintet implicated in circadian rhythms of Arabidopsis thaliana : II. Characterization with CCA1-overexpressing plants"Plant Cell Physiol.. 43. 118-122 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Murakami-Kojima, M. et al.: "The APRR3 component of the clock-associated APRR1/TOC1 quintet is phosphorylated by a novel protein kinase belonging to the WNK family, the gene for which is also transcribed rhythmically in Arabidopsis thaliana"Plant Cell Physiol.. 43. 675-683 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hosoda, K. et al.: "Molecular Structure of the GARP Family of Plant Myb-related DNA-binding Motifs of the Arabidopsis Response Regulators"Plant Cell. 14. 2015-2029 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsushika, A. et al.: "Aberrant Expression of the Light-Inducible and Circadian-Regulated APRR9 Gene Belonging to the Circadian-Associated APRR1/TOC1 Quintet Results in the Phenotype of Early Flowering in Arabidopsis thaliana"Plant Cell Physiol.. 43. 833-843 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kiba, T. et al.: "Characterization of the ARR15 and ARR16 response regulators with special reference to the cytokinin signaling pathway mediated by the AHK4 histidine kinase in roots of Arabidopsis thaliana"Plant Cell Physiol.. 43. 1059-1066 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sato, E. et al.: "Aberrant expression of the Arabidopsis circadian-regulated APRR5 gene belonging to the APRR1/TOC1 quintet results in early folwering and htpersensitiveness to light in early photomorphogenesis"Plant Cell Physiol.. 43. 1374-1385 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Makino, S.: "Light response of the circadian waves of the APRR1/TOC1 uintet : When does the quintet start singing rhythmically in Arabidopsis thaliana"Plant Cell Physiol.. 42. 334-339 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suzuki, T.: "Two-types of putative nuclear factors that physically interact with histidine-containing phosphotransfer(HPt)signal transducers implicated in His-to-Asp phosphorelay in Arabidopsis"Plant Cell Physiol.. 42. 37-45 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suzuki, T.: "The Arabidopsis sensor His-kinase,AHK4,can respond to cytokinin"Plant Cell Physiol.. 42. 107-113 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ueguchi, C.: "Novel family of sensor histidine kinase genes in Arabidopsis thaliana"Plant Cell Physiol.. 42. 231-235 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Imamura, A.: "Cellular localization of the signaling components of Arabidopsis His-to-Asp phosphorelay"Biosci.Biotechnol.Biochem.. 65. 2113-2117 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamada, H.: "The Arabidopsis AHK4 histidine kinase is a cytokinin-binding receptor that transduses cytokinin signals across the membrane"Plant Cell Physiol.. 42. 1017-1023 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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