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Positional cloning of genes responsible for animal behavior and analysis of gene polymorphisms as a tool for genetic analysis

Research Project

Project/Area Number 13480282
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionNATIONAL INSTITUTE OF GENETICS

Principal Investigator

KOIDE Tsuyoshl  GENETIC STRAINS RESEARCH CENTER, ASSOCIATE PROFESSOR, 系統生物研究センター, 助教授 (20221955)

Co-Investigator(Kenkyū-buntansha) SHIROISHI Toshihiko  GENETIC STRAINS RESEARCH CENTER, PROFESSOR, 系統生物研究センター, 教授 (90171058)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥17,100,000 (Direct Cost: ¥17,100,000)
Fiscal Year 2002: ¥8,300,000 (Direct Cost: ¥8,300,000)
Fiscal Year 2001: ¥8,800,000 (Direct Cost: ¥8,800,000)
KeywordsWild mouse / Behavior / Genetics / Polymorphism / Genetic mapping / OTL / 遺云子多型 / 行動遺伝学 / 遺伝子マッピング
Research Abstract

We previously conducted multi-phenotype behavioral characterizations using a series of inbred strains derived from wild mice in addition to the common laboratory strains, the Mishima battery of mouse strains. In the study of spontaneous locomotor activity in the habituated normal home cages using infrared sensor, we found that mice of KJR strain was hyperactive in contrast to mice of BLG2 strain, which showed a low level of spontaneous locomotion. To unravel the genetic loci involved in this behavioral phenotype, we conducted QTL analysis on backcross populations of a cross between KJR and BLG2 strains. In the QTL analysis with 282 backcross progeny, two loci were found to be involved in the different spontaneous activity.
In the systematic screening in the public database for genes carrying poly-glutamine repeats in the products, we listed 50 genes in total We analyzed variation of the repeat length in the 62 loci among 16 inbred strains of mouse by PCR analysis followed by DNA sequencing. We fond high degree of polymorphism among strains.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Isobe et al.: "Molecular characterization of Pb recombination hotspot in the mouse major histocompatibility complex class I region"Genomics. 229. 229-235 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Chan et al.: "Maternal diabetes increases the risk of caudal regression caused by retinoic acid"Diabetes. 51. 2811-2816 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Furuse et al.: "QTL analyses of spontaneous locomotor activity using mouse strains of Mishima battery"Mammalian Genome. 13. 411-415 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Furuse te al.: "Genetic diversity underlying capsaicin intake in the Mishima battery of mouse strains"Brain Research Bulletin. 57. 49-55 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Furuse, T., Blizard, D. A., Moriwaki, K., Miura, Y., Yagasaki, K., Shiroishi, T., Koide, T.: "Genetic diversity underlying capsaicin intake in the Mishima battery of mouse strains"Brain Research Bulletin. 57. 49-55 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Furuse, T., Takano-Shimizu, T., Moriwaki, K., Shiroishi, T., Koide, T.: "QTL analyses of spontaneous locomotor activity using mouse strains from Mishima battery"Mammalian Genome. 13. 411-415 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Chan, B. W. H., Chan, K.-S., Koide, T., Yeung, S.-M., Leung, M. B. W., Copp, A. J., Loeken, M. R., Shiroishi, T., Shum, A. S. W.: "Maternal Diabetes Increases the Risk of Caudal Regression Caused by Retinoic Acid"Diabetes. 51. 2811-2816 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Isobe, T., Yoshino, M., Mizuno, K, Fisher Lindahl, K., Koide, T., Gaudiery, S., Gojobori, T., Shiroishi, T.: "Molecular characterization of the Pb recombination hotspot in the mouse major histocompatibility complex class I region"Genomics. 80. 229-235 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Isobe et al.: "Molecular characterization of Pb recombination hotspot in the mouse major histocompatibility complex class I region"Genomics. 229. 229-235 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Chan et al.: "Maternal diabetes increases the risk of caudal regression caused by retinoic acid"Diabetes. 51. 2811-2816 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Furuse et al.: "QTL analyses of spontaneous locomotor activity using mouse strains of Mishima battery"Mammalian Genome. 13. 411-415 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Furuse te al.: "Genetic diversity underlying capsaicin intake in the Mishima battery of mouse strains"Brain Research Bulletin. 57. 49-55 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Furuse, Blizard, Moriwaki, Miura, Yagasaki, Shiroishi, Koide: "Genetic diversity underlying capsaicin intake in the Mishima battery of mouse strains"Brain Research Bulletin. 57. 49-55 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Furuse, Takano-S., Moriwaki, Shiroishi, Koide: "QTL analyses of spontaneous activity using mouse strains from Mishima battery"Mammalian Genome. (投稿中).

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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