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Measurement of the neural activation potential of rat cerebral cortex using functional optical reflection tomography

Research Project

Project/Area Number 13480293
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionOsaka University

Principal Investigator

HARUNA Masamitsu  Osaka University, Faculty of Medicine, Professor, 医学部, 教授 (20029333)

Co-Investigator(Kenkyū-buntansha) MAKI Atsushi  Hitachi Ltd., Research Scientist, 研究員
OHMI Masato  Osaka University, Faculty of Medicine, Research Associate, 医学部, 助手 (60273645)
KANOSUE Kazuyuki  Osaka University, Faculty of Medicine, Professor, 医学部, 教授 (50127213)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥9,300,000 (Direct Cost: ¥9,300,000)
Fiscal Year 2002: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2001: ¥5,800,000 (Direct Cost: ¥5,800,000)
KeywordsFunctional reflection optical tomography (f-ORT) / Coherence gate (OCT) / Neural activation potential / Measurement of refractive index of biological tissue / Analysis of brain function
Research Abstract

Our research target is proposal and demonstration of a novel functional optical reflection tomography (f-ORT). This unique technique is used for measurement of spatial and temporal distribution of neural activation potential of the cerebral cortex of rats, showing that the f-ORT is effective for brain neurology.
(1) A SLD is used as the light source of the existing optical coherence tomography (OCT); however, the coherence length of SLD is 10 to 20 μm which is insufficient for detection of neural activation potential. In order for the detection, the SLD was replaced by a mode-locked Ti:sapphire laser which supplied the pulsewidth as short as lOfs. This laser can provide us OCT with the spatial resolution of 3 μm after proper compensation of chromatic dispersion of the interferometer.
(2) In order to the high-resolution OCX described above, we developed the 1,3-μm OCT in which the imaging depth is improved to be 1.5mm or more. Subsequently, the desired optical reflection tomography was de … More veloped by combination of the coherence-gate optics and confocal optics.
(3) The imaging data must be acquired as fast as possible in order to detect the neural activation potential in synchronization with the cardiac rate. Such a high-speed data acquisition can be realized by non-mechanical optical-delay scanning. In the f-ORT, the optical-delay scanning is performed by PZT fiber phase modulators, as a result, more than 50 optical-delay scans per second were obtained. All the raster scan signals are summed up to improve drastically the signal-to-noise ratio.
(4) In the preliminary experiment, a refractive index change was detected by the f-ORT when a sound stimulus was applied to a rat. The index change may correspond to the neural activation potential due to a sound stimulus. A remarkable change of the optical reflection signal was detected in a 100-μm deep area 20s after application of the sound stimulus. On the basis of research results, as mentioned above, we have been developing the f-ORT for brain neurology. Less

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (56 results)

All Other

All Publications (56 results)

  • [Publications] Masato Ohmi: "Optical reflection tomography along the geometrical thickness"Proc.SPIE, Progress in Biomed.Opt. & Imaging. Vol.4251. 76-80 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "In situ tomographic observation of tissue sufface during laser ablation"Proc.SPIE, Progress in Biomed.Opt. & Imaging. Vol.4257. 329-333 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masato Ohmi: "Optical reflection tomography along the geometrical thickness toward in vivo imaging of biological tissue"Conf.Lasers & Electro-Optics (CLEO/PR2001). Technical Digest. 356-357 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Rhyu Konoshita: "Measurement of calcium of biological tissues along the depth by laser ablation"Conf. Lasers & Electro-Optics (CLEO/PR2001). Technical Digest. 238-239 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Novel low-coherence interferometric technique in biomedical measurement and imaging"Joint Symposium on Bio-Sensing and Bio-Imaging. Technical Digest. 140-145 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masato Ohmi: "Comparison of 0.8μm and 1.3μm images of optical coherence tomography using fiber-optic low-coherence interferometers"The 8th Microoptics Conf (MOC'01). Technical Digest. 88-91 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 春名 正光: "光コヒーレンストモグラフィ(OCT)"O plus E. Vol.24No.2. 167-171 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 丸山 秀樹: "低コヒーレンス光干渉を用いた屈折率と厚さ同時測定による樹脂硬化評価への応用"電子情報通信学会論文誌. Vol.J85-CNo.2. 103-106 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hideki Maruyama: "Low-coherence interferometer system for the simultaneous measurement of refractive index and thickness"Applied Optics. Vol.41No.7. 1315-1322 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Huijuan Zhao: "Imaging of in vitro chicken leg using time-resolved near-infrared optical tomography"Physics in Medicine and Biology. Vol.47. 1979-1993 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 春名 正光: "特集:生体光トモグラフィ・光トポグラフィ-実用化と新たな技術展開-"オプトロニクス. No.247. 176-178 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 近江 雅人: "実サイズ光トモグラフィ"オプトロニクス. No.247. 184-188 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Recent development in optical coherence tomography for clinical diagnoses"3rd Asian Pacific Laser Symposium (APLS2002). Technical Digest. 165-170 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Quasi in-focus OCT using multiple tomography with shift of the lens focal plane"Asian Symposium on Biomedical Optics and Photomedicime (BOPM2002). Technical Digest. 114-115 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masato Ohmi: "Ultra-high resolution OCT using a halogen lamp as the light source"Asian Symposium on Biomedical Optics and Photomedicime (BOPM2002). Technical Digest. 116-117 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Detection of phase transition of biological membranes by the low coherence interferometry : Effect of circumstances of membrane on the phase transition"Asian Symposium on Biomedical Optics and Photomedicime (BOPM2002). Technical Digest. 144-145 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 春名 正光: "低コヒーレンス光干渉を用いた生体計測と断層イメージング"応用光学. Vol.3. 1-6 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 春名 正光(共著): "『ポストゲノム時代の内視鏡学』、21.光コヒーレンストモグラフィ"中山書店. 147-152 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masato Ohmi: "Optical reflection tomography along the geometrical thickness"Proc. SPIE, Progress in Biomed. Opt. & Imaging. Vol. 4251. 76-80 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "In situ tomographic observation of tissue surface during laser ablation"Proc. SPIE, Progress in Biomed. Opt. & Imaging. Vol. 4257. 329-333 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masato Ohmi: "Optical reflection tomography along the geometrical thickness toward in vivo imaging of biological tissue"The 4th Pacific Rim Conference on Lasers and Electro-Optics (CLEO/PR2001). Vol. 1. 356-357 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Rhyu Konishita: "Measurement of calcium of biological tissues along the geometrical thickness toward in vivo imaging of biological tissue"The 4th Pacific Rim Conference on Lasers and Electro-Optics (CLEO/PR2001). Vol. 1. 238-239 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Novel low-coherence interferometric technique in biomedical measurement and imaging"Proc. Joint Symposium on Bio-Sensing and Bio-Imaging. 140-145 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masato Ohmi: "Comparison of 0.8μm and 1.3μm images of optical coherence tomography using fiber-optic low-coherence interferometers"Proc. The 8th Microoptics Conf. (MOC'Ol). 88-91 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Optical coherence tomography (OCT)"O plus E. Vol. 24, No. 2. 167-171 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hideki Maruyama: "Evaluation of hardening of UV-light cured epoxy by simultaneous measurement of refractive index and thickness using the low cohdrenee-interferometry"The transaction of the institute of electronics. Vol. J85-C, No. 2. 103-106 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hideki Maruyama: "Low-coherence interferometer system for the simultaneous measurement of refractive index and thickness"Applied Optics. Vol. 41, No. 7. 1315-1322 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Huijuan Zhao: "Imaging of in vitro chicken leg using time-resolved near-infrared optical tomography"Physics in Medical and Biology. Vol. 47. 1979-1993 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Optical tomography and optical topography"Optronics. Vol. 247. 176-178 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masato Ohmi: "Optical tomography along the geometrical thickness"Optronics. Vol. 247. 184-188 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Recent development in optical coherence tomography for clinical diagnoses"Proc. 3rd Asian Pacific Laser Symposium (APLS2002). 165-170 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Quasi in-focus OCT using multiple tomography with shift of the lens focal plane"Proc. Asian Symposium on Biomedical Optics and Photomedicine (BOPM2002). 114-115 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masato Ohmi: "Ultra-high resolution OCT using a halogen lamp as the light source"Proc. Asian Symposium on Biomedical Optics and Photomedicine (BOPM2002). 116-117 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Detection of phase transition of biological membranes by the low coherence interferometry: Effect of circumstances of membrane on the phase transition"Proc. Asian Symposium on Biomedical Optics and Photomedicine (BOPM2002). 116-117 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Masamitsu Haruna: "Biomedical-optic measurement and tomographic imaging using the low coherence interferometry"Applied Optics(in Japanese). Vol. 3. 1-6 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 春名 正光: "光コヒーレンストモグラフィ(OCT)"O plus B. Vol.24 No.2. 167-171 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 丸山 秀樹: "低コヒーレンス光干渉を用いた屈折率と厚さ同時測定による樹脂硬化評価への応用"電子情報通信学会論文誌. Vol.J85-C No.2. 103-106 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hideki Maruyama: "Low-coherence interferometer system for the simultaneous measurement of refractive index and thickness"Applied Optics. Vol.41 No.7. 1315-1322 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Huijuan Zhao: "Imaging of in vitro chicken leg using time-resolved near-infrared optical tomography"Physics in Medicine and Biology. Vol.47. 1979-1993 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 春名 正光: "特集:生体光トモグラフィ・光トポグラフィ-実用化と新たな技術展開-"オプトロニクス. No.247. 176-178 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 近江 雅人: "実サイズ光トモグラフィ"オプトロニクス. No.247. 184-188 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masamitsu Haruna: "Recent development in optical coherence tomography for clinical diagnoses"3rd Asian Pacific Laser Symposium (APLS2002)Technical Digest. (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masamitsu Haruna: "Quasi in-focus OCT using multiple tomography with shift of the lens focal plane"Asian Symposium on Biomedical Optics and Photomedicime (BOPM2002)Technical Digest. 114-115 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masato Ohmi: "Ultra-high resolution OCT using a halogen lamp as the light source"Asian Symposium on Biomedical Optics and Photomedicime (BOPM2002)Technical Digest. 116-117 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masamitsu Haruna: "Detection of phase transition of biological membranes by the low coherence interferometry : Effect of circumstances of membrane on the phase transition"Asian Symposium on Biomedical Optics and Photomedicime (BOPM2002)Technical Digest. 144-145 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 春名 正光: "低コヒーレンス光干渉を用いた生体計測と断層イメージング"応用光学. Vol.3. 1-6 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] 春名 正光(共著): "『ポストゲノム時代の内視鏡学』、21.光コヒーレンストモグラフィ"中山書店. 147-152 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Masamitsu Haruna: "In situ tomographic observation of tissue surface during laser ablation"Proc. SPIE, Progress in Biomed. Opt. & Imaging. Vol.4257. 329-333 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masato Ohmi: "Optical reflection tomography along the geometrical thickness"Proc. SPIE, Progress in Biomed. Opt. & Imaging. Vol.4251. 76-80 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 春名 正光: "光コヒーレンストモグラフィ(OCT) -原理と開発の現状-"臨床消化器内科. Vol.16. 131-133 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 春名 正光: "生体のマイクロ光診断と実サイズ光トモグラフィ"O Plus E. Vol.23. 86-89 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masato Ohmi: "Optical reflection tomography along the geometrical thickness toward in vivo imaging of biological tissue"Conf. Lasers & Electro-Optics (CLEO/PR2001). Technical Digest. 356-357 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Rhyu Konoshita: "Measurement of calcium of biological tissues along the depth by laser ablation"Conf. Lasers & Electro-Optics (CLEO/PR2001). Technical Digest. 238-239 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masamitsu Haruna: "Novel Low-coherence interferometric technique in biomedical measurement and imaging"Joint Symposium on Bio-Sensing and Bio Imaging. Technical Digest. (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masato Ohmi: "Comparison of 0.8μm and 1.3 μm images of optical coherence tomography using fiber-optic low-coherence interferometers"The 8th Microoptics Conf. (MOC'01). Technical Digest. 88-91 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 春名 正光: "光コヒーレンストモグラフィ(OCT)"O plur E. Vol.24. 168-171 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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