| Project/Area Number |
13480300
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
FURUZONO Tsutomu National Cardiovascular Center Research Institute, Department of Biomedical Engineering, Division Head, 生体工学部, 室長 (30332406)
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| Co-Investigator(Kenkyū-buntansha) |
KISHIDA Akio National Cardiovascular Center Research Institute, Department of Biomedical Engineering, Director, 生体工学部, 部長 (60224929)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2003: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2002: ¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 2001: ¥6,200,000 (Direct Cost: ¥6,200,000)
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| Keywords | Fluorine-containing polymer / Aramid / Block copolymer / High intensity and water repellence / Biomedical material / 重縮合 / ペプチド合成試薬 |
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| Research Abstract |
In the medical field, it is well known that polytetrafluoroethylene (PTFE) is applied to artificial vessels due to their low bioactivity. However, one of the clinical problems caused by PTFE is ischemia by twist in living body. We selected the aromatic polyamides (aramids) as another functional material to overcome the problem of the mechanical properties of PTFE. The target of this study is the development of novel artificial vessels by synthesizing the block copolymer containing fluoroethylene and aramid segments.
1)The synthesis of the block copolymers containing fluoroethylene and aramid segments
First, a block copolymer was synthesized by low-temperature solution polycondensation of telechelic diamine containing fluoroethylene segments and isophthaloyl chloride [JP Patent 2002-252183 (2002), J.Polym.Sci., Part A : Polym. Chem., 41, 2840 (2003)]. Secondary block copolymers containing chain-controlled aramid and fluoroethylene number-average molecular weight of these copolymers were 1.7×10^4 and 2.0×10^4, respectively. We attempted the preparation of cast films from these copolymers. These films had uniform thickness, but do not have good mechanical properties.
2)The analyses of the surface and physical properties
We planned the analysis of the surface and physical properties of these copolymers. But we could not evaluate these properties because too much time was taken to synthesize these copolymers and prepare films. It is assumed that it is possible to synthesize the block copolymer having good mechanical properties by distribution adjustment of fluoroethylene and aramid segments. By overcome the problem of mechanical properties, it is expected that these copolymers are applied artificial vessels.
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