• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Construction of Molecular Devise using Metal Complex-type Artificial DNA 60187333

Research Project

Project/Area Number 13554024
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Inorganic chemistry
Research InstitutionThe University of Tokyo

Principal Investigator

TANAKA Kentaro  The University of Tokyo, Graduate School of Science, Associate Professor, 大学院・理学系研究科, 教授 (60187333)

Co-Investigator(Kenkyū-buntansha) ASAO Tetsuji  Taiho Pharmaceutical Co. Ltd., Director (Researcher), 化学研究所, 所長(研究職)
HIRAOKA Shuichi  The University of Tokyo, Graduate School of Science, Doctor, 大学院・理学系研究科, 助手 (10322538)
田中 健太郎  東京大学, 大学院・理学系研究科, 助教授 (40281589)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥14,300,000 (Direct Cost: ¥14,300,000)
Fiscal Year 2002: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2001: ¥10,900,000 (Direct Cost: ¥10,900,000)
KeywordsArtifical DNA / Metal Complex / Self-Assebmly / Nucleoside / Oligonuclentide / DNA / 核酸塩基 / 遺伝子 / ピリジン
Research Abstract

DNA has a structural basis to array functionalized building blocks. In this study, one to five Cu^<2+>-mediated base pairs of hydroxypyridone nucleobases have been systematically incorporated into the middle of a DNA duplex, resulting in the formation of a magnetic chain by the line-up of mono- to pentanuclear Cu^<2+> complexes stacked within the DNA helix. The Cu^<2+> ions in each complex couple ferromagnetically with one another through unpaired d electrons. An outline of a right-handed, double-stranded structure with Cu^<2+> array inside the DNA is proposed, where the Cu^<2+>-Cu^<2+> distance is almost the same as that between natural base pairs. This strategy represents a new method for arranging metal ions in solution in a discrete and predictable fashion and contrasts with the non-biological approach of others, leading to the possibility of metal-based molecular devices such as molecular magnets and wires.

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] M.Tasaka, K.Tanaka, M.Shiro, M.Shionoya: "Towards Nano-Assembly of Metals with Engineered DNAs"Supramolecular chemistry. 13. 255-261 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Tanaka, Y.Yamada, M.Shionoya: "Formation of Silver(I)-Mediated DNA Duplex and Triplex through an Alternative Base Pair of Pyridine Nucleobases"Journal of the American chemical society. 124. 8802-8803 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S.Aketani, K.Tanaka, K.Yamamoto, A.Ishihama, H.Cao, A.Tengeiji, S.Hiraoka, M.Shiro, M.Shionoya: "Syntheses and Structure-Activity Relationships of Nonnatural β-C-Nucleoside 5'-Triphosphates Bearing an Aromatic Nucleobase with Phenolic Hydroxyl Groups : Inhibitory Activities against DNA Polymerases"Journal of medicinal chemistry. 45. 5594-5603 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Tanaka, A.Tengeiji, T.Kato, N.Toyama, M.Shiro, M.Shionoya: "Efficient Incorporation of A Copper Hydroxypyridone Base Pair in DNA"Journal of the American chemical society. 124. 12494-12498 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K.Tanaka, A.Tengeiji, T.Kato, N.Toyama, M.Shionoya: "A Discrete Self-Assembled Metal Array in Artificial DNA"Science. 299. 1212-1213 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M. Tasaka, K. Tanaka, M. Shiro, and M. Shionoya: "Toward Nano-Assembly of Metals through Engineered DNAs"Supramolecular chemistry. 13. 255-261 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Tanaka, Y. Yamada, and M. Shionoya: "Formation of Silver(I)-Mediated DNA Duplex and Triplex through an Alternative Base Pair of Pyridine Nucleobases"Journal of the American chemical society. 124. 8802-8803 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] S. Aketani, K. Tanaka, K. Yamamoto, A. Ishihama, H. Cao, A. Tengeiji, S. Hiraoka, M. Shiro, and M. Shionoya: "Syntheses and Structure-Activity Relationships of Nonnatural β-C-Nucleoside 5'-Triphosphates Bearing an Aromatic Nucleobase with Phenolic Hydroxy Groups : Inhibitory Activities against DNA Polymerases"Journal of medicinal chemistry. 45. 5594-5603 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Tanaka, A. Tengeiji, T. Kato, N. Toyama, M. Shiro, and M. Shionoya: "Efficient Incorporation of A Copper Hydroxypyridone Base Pair in DNA"Journal of the American chemical society. 124. 12494-12498 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] K. Tanaka, A. Tengeiji, T. Kato, N. Toyama, and M. Shionoya: "A Discrete Self-Assembled Metal Array in Artificial DNA"Science. 299. 1212-1213 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] M.Tasaka, K.Tanaka, M.Shiro, M.Shionoya: "Toward Nano-Assembly of Metals through Engineered DNAs"Supramolecular chemistry. 13. 255-261 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Tanaka, Y.Yamada, M.Shionoya: "Formation of Silver(I)-Mediated DNA Duplex and Triplex through an Alternative Base Pair of Pyridine Nucleobases"Journal of the American chemical society. 124. 8802-8803 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Aketani, K.Tanaka, K.Yamamoto A.Ishihama, H.Cao, A.Tengeiji, S.Hiraoka, M.Shiro, M.Shionoya: "Syntheses and Structure-Activity Relationships of Nonnatural β-C-Nucleoside 5'-Triphosphates Bearing an Aromatic Nucleobase with Phenolic Hydroxy Groups : Inhibitory Activities against DNA Polymerases"Journal of medicinal chemistry. 45. 5594-5603 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Tanaka, A.Tengeiji, T.Kato, N.Toyama, M.Shiro, M.Shionoya: "Efficient Incorporation of A Copper Hydroxypyridone Base Pair in DNA"Journal of the American chemical society. 124. 12494-12498 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] K.Tanaka, A.Tengeiji, T.Kato, N.Toyama, M.Shionoya: "A Discrete Self-Assembled Metal Array in Artificial DNA"Science. 299. 1212-1213 (2003)

    • Related Report
      2002 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi