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Development of surface modification technology of titanium alloys for artificial bones using phosphate glasses

Research Project

Project/Area Number 13555173
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Inorganic materials/Physical properties
Research InstitutionNagoya Institute of Technology

Principal Investigator

KASUGA Toshihiro  Nagoya Institute of Technology, Graduate School of Engineering, Associate Professor, 工学研究科, 助教授 (30233729)

Co-Investigator(Kenkyū-buntansha) NIINOMI Mitsuo  Toyohashi University of Technology, Faculty of Engineering, Professor, 工学部, 教授 (50126942)
HAYAKAWA Tomokatsu  Nagoya Institute of Technology, Research Associate, 工学研究科, 助手 (00293746)
NOGAMI Masayuki  Nagoya Institute of Technology, Professor, 工学研究科, 教授 (90198573)
HATTORI Tomokazu  Meijo University, Faculty of Science and Engineering, Associate Professor, 理工学部, 助教授 (40172936)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥9,700,000 (Direct Cost: ¥9,700,000)
Fiscal Year 2003: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2002: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2001: ¥5,000,000 (Direct Cost: ¥5,000,000)
KeywordsPhosphate glass / Bonelike apatite / Glass / Glass-ceramic / Bioactivity / Simulated body fluid / Titanium alloy / High strength
Research Abstract

A bioactive calcium phosphate invert glass-ceramic containing β-Ca_3(PO_4)_2 crystals could be joined strongly with a Ti-29Nb-13Ta-4.6Zr alloy consisting of a β-titanium phase by heating the metal, on which the mother glass powders with a composition 60CaO-30P_2O_5-7Na_2O-3TiO_2 in mol% were placed, at 800℃ for 1 h in air ; the tensile joining strength was estimated to be 〜26MPa on average. A compositionally gradient layer was developed on the metallic substrate during the heating. The joining between the glass-ceramic and the metal is suggested to be controlled by viscous, flow of the glassy phase in the glass-ceramic and by reaction of the glassy phase with the oxide phase formed around the surface layer of the metal.
Bonelike apatite formation was observed on the glass-ceramic after 20 days of soaking in simulated body fluid (SBF). We found the apatite-forming ability of the glass-ceramic can be easily improved by autoclaving treatment in water. When the autoclaved sample was soaked in SBF, bonelike apatite began to form after 3 days. On the other hand, no apatite formed on the glass-ceramic, which was not autoclaved, even by soaking in SBF for 10 days. During the autoclaving, titanium ions in the amorphous phases around the surface form anatase phase and the hydrated titania groups, which may play an important role in the apatite formation.. A rod sample of the treated titanium alloy was implanted into a femur of rabbit. After 4-week implantation, newly formed bones were seen around the sample and they contacted directly without fibrous tissue.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Toshihiro Kasuga, et al.: "Calcium phosphate invest glass-ceramic coatings joined by self-development of compositionally gradient layers on a titanium alloy"Biomaterials. 22. 577-582 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toshihiro Kasuga, et al.: "Bioactive calcium phosphate invert glass-ceramic coating on β-type Ti-29Nb-13Ta-4.6Zr alloy"Biomaterials. 24. 283-290 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] toshihiro Kasuga, et al.: "Joining of Calcium Phoshate Invert Glass-Ceramics on a β-type Titanium Alloy"J.Am.Ceram.Soc.. 86. 1031-1033 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toshihiro Kasuga, et al.: "Calcium Phosphate Glass-Ceramics for Bioactive Coating on a β-Type Titanium Alloy"Adv.Engng.Mater.. 5. 498-501 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toshihiro Kasuga, et al.: "Enhancement of Biomimetic Apatite Forming Ability of Calcium Phosphate Glass-Ceramic by a Hydrothermal Treatment"J.Ceram.Soc.Japan. 111. 633-635 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Kasuga, et al.: "Apatite-Forming Ability of Calcium Phosphate Glass-Caramics Improved by Autoclaving"Key Engng.Mater.. 254-256. 753-756 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toshihiro Kasuga, Masayuki Nogami, Mitsuo Niinomi: "Preparation of Calcium Phosphate Glass-Ceramics and Their Coating on Titanium Alloys"Key Engng.Mater.. 192-195. 223-226 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toshihiro Kasuga, Yoshimasa Hosoi, Masayuki Nogami, Mitsuo Niinomi: "Apatite Formation on Calcium Phosphate Invert Glasses in Simulated Body Fluid"J.Am.Ceram.Soc.. 84. 450-452 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toshihiro Kasuga, Takeshi Mizuno, Mikio Watanabe, Masayuki Nogami, Mitsuo Niinomi: "Calcium phosphate invert glass-ceramic coatings joined by self-development of compositionally gradient layers on a titanium alloy"Biomaterials. 22. 577-582 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toshihiro Kasuga, Masayuki Nogami, Mitsuo Niinomi: "Preparation of Bioactive Calcium Pyrophosphate Glass-Ceramics"J.Mater.Sci.Lett.. 20. 1249-1251 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Mitsuo Niinomi, Tomokazu Hattori, Keizo Morikawa, Toshihiro Kasuga, Akihiro Suzuki, Hisao Fukui, Shigeo Niwa: "Development of Low Rigidity β-type Titanium Alloy for Biomedical Applications"Mater.Trans.. 43. 2970-2977 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Kasuga, T.Fujimoto, Y.Hosoi, M.Nogami: "Calcium Phosphate Invert Glasses and Glass-Ceramics with Apatite-Forming Ability"Key Engng.Mater.. 240-242. 265-268 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toshihiro Kasuga, Masayuki Nogami, Mitsuo Niinomi, Tomokazu Hattori: "Bioactive calcium phosphate invert glass-ceramic coating on β-type Ti-29Nb-13Ta-4.6Zr alloy"Biomaterials. 24. 283-290 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toshihiro Kasuga, Masayuki Nogami, Mitsuo Niinomi: "Joining of Calcium Phosphate Invert Glass-Ceramics on a β-type Titanium Alloy"J.Am.Ceram.Soc.. 86. 1031-1033 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toshihiro Kasuga, Masayuki Nogami, Mitsuo Niinomi: "Calcium Phosphate Glass-Ceramics for Bioactive Coating on a β-Type Titanium Alloy"Adv.Engng.Mater.. 5[7]. 498-501 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Toshihiro Kasuga, Tatsuya Fujimoto, Masayuki Nogami: "Enhancement of Biomimetic Apatite Forming Ability of Calcium Phosphate Glass-Ceramic by a Hydrothermal Treatment"J.Ceram.Soc.Japan. 11. 633-635 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Kasuga, T.Fujimoto, C.Wang, M.Nogami: "Apatite-Forming Ability of Calcium Phosphate Glass-Ceramics Improved by Autoclaving"Key Engng.Mater.. 254-256. 753-756 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] T.Kasuga, 他: "Calcium Phosphate Invert Glasses and Glass-Ceramics with Apatite-Forming Ability"Key Engng.Mater.. 240-242. 265-268 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toshihiro Kasuga, 他: "Bioactive Calcium Phosphate Invert Glass-Ceramic Coating on B-Type Ti-29Nb-13Ta-4.6Zr Alloy"Biomaterials. 24. 283-290 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toshihiro Kasuga, 他: "Joining of Calcium Phosphate Invert Glass-Ceramics on a a-type Titanium Alloy"J.Am.Ceram.Soc.. 86. 1031-1033 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toshihiro Kasuga, 他: "Novel Machinable Calcium Phosphate Glass-Ceramics for Biomedical Use"Mater.Sci.Forum. 426-432. 3183-3188 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toshihiro Kasuga, 他: "Calcium Phosphate Glass-Ceramics for Bioactive Coating on a a-Type Titanium Alloy"J.Engng.Mater.. 5. 498-501 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toshihiro Kasuga, 他: "Enhancement of Biomimetic Apatite Forming Ability of Calcium Phosphate Glass-Ceramic by a Hydrothermal Treatment"J.Ceram.Soc.Japan. 111. 633-635 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Toshihiro Kasuga: "Machinable Calcium Phosphate Ceramics"Phosphorus Res.Bull.. 13. 153-158 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toshihiro Kasuga: "Machinable Glass-Ceramics Containing Calcium Pyrophosphate Crystal"Phys.Chem.Glass. 43C. 314-316 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toshihiro Kasuga: "Calcium Phosphate Invert Glasses and Glass-Ceramics with Apatite-Forming Ability"Key Engng.Mater.. 240-242. 265-268 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toshihiro Kasuga: "Bioactive calcium phosphate invert glass-ceramic coating on β-type Ti-29Nb-13Ta-4.6Zr alloy"Biomaterials. 24. 283-290 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mitsuo Niinomi: "Development of Low Rigidity β-type Titanium Alloy for Biomedical Applications"Mater.Trans.. 43. 2970-2977 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toshihiro Kasuga: "Joining of calcium phosphate invert glass-ceramics on a β-type titanium alloy"J.Am.Ceram.Soc.. (掲載決定). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toshihiro Kasuga: "Biomaterials and Tissue Engineering (Chapter 4:Biocomposite Materials for Biotechnology)"Springer-verlag. (Chap.4)31 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Toshihiro Kasuga: "Preparation of bioactive calcium phosphate glass-ceramics"Journal of Materials Science Letters. 20. 1249-1251 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Toshihiro Kasuga: "Biomimetic apatite formation of calcium phosphate invert glasses"Phosphorus Research Bulletin. 12. 39-44 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Toshihiro Kasuga: "Apatite formation of TiO_2 in simulated body fluid"Journal of Crystal Growth. 235. 235-240 (2002)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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