| Project/Area Number |
13555227
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
生物・生体工学
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| Research Institution | Kobe University |
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Principal Investigator |
TAKEUCHI Toshifumi Kobe University, Graduate School of Science and Technology, Professor, 自然科学研究科, 教授 (70179612)
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| Co-Investigator(Kenkyū-buntansha) |
MAKINO Kenji Nissan Chemical Industries, Organic Materials Dept., Development Manager, 機能材料事業部, 主席(研究職)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2003: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2002: ¥4,300,000 (Direct Cost: ¥4,300,000)
Fiscal Year 2001: ¥8,100,000 (Direct Cost: ¥8,100,000)
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| Keywords | Molecular Imprinting / Molecular Recognition / Catalysts / Combinatorial Chemistry |
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| Research Abstract |
Atrazine imprinted synthetic polymers were prepared with a combined use of binding (methacrylic acid) and catalytic (2-sulfoethyl methacrylate) functional monomers, in which atrazine and other 6-chloro triazine herbicides were bound and converted to less toxic compounds. A chloride at the 6-position was converted to a methoxy group by the polymer in a methanol-containing solvant, where the imprinting effects enhanced the catalytic activity. Competitive inhibition of the atrazine transformation was observed in the presence of a structurally related binder, ametryn, suggesting that the catalytic reaction proceeded in the binding sites generated by the molecular imprinting process.
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