| Project/Area Number |
13557028
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Hygiene
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| Research Institution | Hokkaido University |
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Principal Investigator |
FUJITA Hiroyoshi Hokkaido Univ., School of Med., Prof., 大学院・医学研究科, 教授 (60142931)
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| Co-Investigator(Kenkyū-buntansha) |
IGARASHI Kazuhiko Hiroshima Univ.School of Med., Prof., 医学部, 教授 (00250738)
SHIBAHARA Shigeki Tohoku Univ.School of Med., Prof., 大学院・医学系研究科, 教授 (70206142)
SATO Haruo Sato Inst.Pharmaceutical Res., Director, 所長(研究職)
OGAWA Kazuhiro Tohoku Univ.School of Med., Instructor, 大学院・医学系研究科, 助手 (30344659)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2003: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2002: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 2001: ¥7,100,000 (Direct Cost: ¥7,100,000)
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| Keywords | metalloporthyrin / heme oxygenase / Bach1 / Nrf2 / transcriptional control / cell differentiation / erythroid cells / ヘム / NO供与体 / ポルフィリン / ヘムオキシゲナーゼ-1 / 転写因子 / 低酸素応答 / 金属 / 白血病発症 / NFE2 / 造血細胞分化 |
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| Research Abstract |
Evaluation of porphyrin derivatives on lives were carried out in the points of effects on cell differentiation as well as on transcription. We, evidenced that Bach1 is the first heme-controlled transcriptional factor in vertebrates. Bach1 is shown to be regulated heme oxygenase-1, which is one of the members of defense system against chemical hazards. Thus, it seems to be possible the evaluation of toxicity via Bach1. In addition, Bach1 also regulates erythroid cell differentiation through globin ge nes. The function of Bach1 can be exchanged by metalloporphyrins other than heme, suggesting some porphyrin derivatives could be applied as drugs to control differentiation.
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