• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of molecules involved in inactivation of mast cells.

Research Project

Project/Area Number 13557040
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 内科学一般
Research InstitutionThe University of Tokyo

Principal Investigator

KITAMURA Toshio  The University of Tokyo, Institute of Medical Science, Professor, 医科学研究所, 教授 (20282527)

Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2003: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2002: ¥4,500,000 (Direct Cost: ¥4,500,000)
Fiscal Year 2001: ¥4,800,000 (Direct Cost: ¥4,800,000)
Keywordsmast cell / NK receptor / allergy / paired Ig receptor / phosphatase / signal sequence trap / ITIMモチーフ / シグナルシークエンストラップ / 膜蛋白質 / シグナル伝達
Research Abstract

We searched for secreted and membrane proteins from cultured bone marrow-derived mouse mast cells using retrovirus-mediated signal sequence trap method SST-REX. From this screening, we identified a novel membrane protein harboring a homology with inhibitory NK receptors. This protein harbors a single immunoglobulin like domain in the extracellular domein and three or four ITIM inhibitory motifs in the intracellular domain, and was designated as LMIRl that stands for Jeukocyte-associated mono Ig receptor-l. From the data base search, we also identified LMIR-2-6 that resemble LMIR1, and isolated full-length cDNAs for these proteins. LMIRl and 3 harbors ITIM motifs in the intracellular domain, and upon ligation, they induced phosphorylation of phosphatases SHP1, SHP2, and SHIP, thereby inducing inhibitory signals. On the other hand, LMIR2, 4, 5, and 6 have short intracellular domain, and associate with activating receptors including DAP10, DAP12 and FcRg through the transmembrane domains. We have developed monoclonal antibodies against LMIR-1-6. To clarify the physiological roles of these molecules especially in the control of mast cell activation, we are now trying to identify the ligands for LMIR1 and 3, and to generate the knockout mice for LMIRI-3.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (140 results)

All Other

All Publications (140 results)

  • [Publications] Kagami, S.: "Role of Stat5a in T Helper Cell Differentiation."Blood. 97. 2358-2365 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirose, K.: "MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody."J.Biol.Chem.. 276. 5821-5828 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kamizono, S.: "The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2."J.Biol.Chem.. 276. 12530-12538 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawashima, T.: "STAT5 induces macrophage differentiation of M1 leukemia cells through activatiion of IL-6 production mediated by NF-κB p65."J.Immunol.. 167. 3652-3660 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tonozuka, Y.: "Molecular cloning of a human novel type I cytokine receptor related to Deltal."Cytogenetics and Cell Genetics. 93. 23-25 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishido, M.: "Cholesterol requirement for receptor transport from multivesicular late endosomes to the Golgi."J.Cell Science. 114. 1965-1976 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tullin, E.E.: "A novel secreted form of immune suppressor factor with high homology to vacuolar ATPase identified by forward genetic approach of functional screening based on cell proliferation."J.Biol.Chem.. 276. 27519-27526 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kimura, M.: "Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene."Immunity. 15. 275-287 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Senga, T.: "JAK/Stat3 dependent activation of RalGDS/Ral pathway in M1 mouse myeloid leukemic cells."J.Biol.Chem.. 276. 32678-32681 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Frasor, J.: "Differential roles for Stat5α and Stat5β in prolactin stimulation of estrogen receptor a and b transcription."Molecular Endcrinol.. 15. 2172-2181 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, S.: "Proleferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord."Exp.Neurol.. 172. 115-127 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tokoro, Y.: "Molecular cloning and characterization of mouse tspan-3, a novel member of the tetraspanin superfamily, expressed on resting dendritic cells."Biochem.Biophys.Res.Commun.. 288. 178-183 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamashita, Y.: "Sak serine-threonine kinase acrts as an effector of Tec tyrosine kinase."J.Biol.Chem.. 276. 39012-39020 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueno, M.: "Identification of an embryonic dorsal aorta specific gene, endomucin, and its inhibitory activity on cell adhesion."Biochem.Biophys.Res.Commun.. 287. 501-506 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ye, S.K.: "The IL-7 receptor controls the accessbility of the TCRγ locus by Stat5 and histone acetylation."Immunity. 15. 813-823 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, S.: "Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord."J.Neurosci.. 21. 9814-9823 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Arakawa, M.: "Negamycin can restore dystrophin in mdx skeletal muscle."Acta.Myologica. 20. 154-158 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitamura, T.: "Role of MgcRacGAP/CYK4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation."Cell Structure and Function. 26. 645-651 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tulin, E.E.: "Genetic approach and phenotype-based complementation screening for identification of stromal cell-derived proteins involved in cell proliferation."Exp.Cell Res.. 272. 23-31 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tulin, E.E.: "Inhibition of human endothelial cell proliferation by ShIF, a vacuolar H+-ATPAse-like protein."Oncogene. 21. 844-848 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sai, X.: "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein."J.Biol.Chem.. 277. 12915-12920 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nosaka, T.: "Pim-1 expression is sufficient to induce cytokine independence in murin hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation."Exp.Hematol.. 30. 697-702 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakamura, T.: "Cytokine receptor common β subunit-mediated STAT5 activation confers NFκB activation in murine pro B cell line Ba/F3 cells."J.Biol.Chem.. 277. 6254-6265 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Perez, O.D.: "Activation of the PKB/AKT pathway by ICAM-2."Immunity. 16. 51-65 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagai, Y.: "Essential role of MD-2 in LPS responsiveness and TLR4 distribution."Nat.Immunol.. 3. 667-672 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Gugasyan, R.: "Dok-related protein negatively regulates T cell development is RasGTPase activating protein and Nck docking sites."J.Cell.Biol.. 158. 115-125 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Stoeclin, G.: "Functional cloning of BRF-1, a regulator of ARE-dependent mRNA turnover."EMBO J.. 21. 4709-4718 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Komano, H.: "A new functional screening system for the identification of DNA encoding a regulator of γ-cleavage."J.Biol.Chem.. 277. 39627-39633 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ezoe, S.: "GATA-2 affects cytokine-dependent growth of hematopoietic cells through accumulation of p21WAF1 and p27Kip1 proteins."Blood. 100. 3512-3520 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yujiri, T.: "MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression."J.Biol.Chem.. 278. 3846-3851 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ozawa, T.: "A genetic approach to identifying mitochondrial proteins."Nat.Biotechnol.. 21. 287-293 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Minoshima, Y.: "Phosphorylation by Aurora B converts MgcRac GAP to a RhoGAP during cytokinesis."Dev.Cell. 4. 549-560 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nosaka, T.: "Mammalian twisted gastulation is essential for skeleto-lymphogenesis."Mol.Cell.Biol.. 23. 2969-2980 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitamura, T.: "Retrovirus-mediated gene transfer and expression cloning, powerful tools in functional genomics."Exp.Hematol.. 31. 1007-1014 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Bao, Y-C.: "Identification of a human cDNA sequence which encodes a novel membrane-associated protein containing a zinc metalloprotease motif."DNA Research. 10. 123-128 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murata, K.: "A novel tyrosine kinase inhibitor GTP14564 specifically inhibits constitutively active fms-like tyrosine kinase 3 through inactivation of STAT5."J.Biol.Chem.. 278. 32892-32898 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueno, H.: "A stromal cell-derived membrane protein that supports hematopoietic stem cells."Nat.Immunol.. 4. 457-463 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hisaoka, T.: "Expression of a member of tumor necrosis factor receptor superfamily, TROY, in the developing and the adult mouse brain."Brain Research. 143. 105-109 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takizawa, M.: "Requirement of gp130 signaling for the AGM hematopoiesis."Exp.Hematol.. 31. 283-289 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tahara, H.: "Reconstitution of CD8+T cells by retroviral transfer of the T-cell receptor ab chain genes isolated from a clonally expanded P815 infiltrating lymphocytes."J.Immunol.. 171. 2154-2160 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kumagai, H.: "Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells."Biochem.Byophys.Res.Commun.. 307. 719-729 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murata, K.: "Selective Cytotoxic Mechanism of GTP-14564, a Novel Tyrosine Kinase Inhibitor in Leukemia Cells Expressing a Constitutively Active Fms-like Tyrosine Kinase 3 (FLT3)."J.Biol.Chem.. 278. 32892-32898 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishiyama, C.: "Functional analysis of PU.1 domains in monocyte-specific gene regulation."FEBS letters. 561. 63-68 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishiyama, C.: "Overproduction of PU.1 in mast cell progenitors : its effect on monocyte-and mast cell-specific gene expression."Biochem.Byophys.Res.Commun.. 313. 516-521 (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ikeda, Y.: "Vasorin, a novel TGF-β binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo."Proc.Natl.Acad.Sci.USA.. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishizama, H.: "Musculin, a novel skeletal muscle-derived secretary factor."J.Biol.Chem.. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kagami, S., Nakajima, H., Suto, A., Hirose, K., Suzuki, K., Morita, S., Kato, I., Saito, Y., Kitamura, T., Iwamoto, I.: "Role of Stat5a in T Helper Cell Differentiation."Blood. 97. 2358-2365 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hirose, K., Kawashima, T., Iwamoto, I., Nosaka, T., Kitamura, T.: "MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody."J. Biol. Chem.. 276. 5821-5828 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kamizono, S., Hanada, T., Yasukawa, H., Minoguchi, S., Kato, R., Minoguchi, M., Hattori, K., Morita, S., Kitamura, T., Kato, H., Nakayama, K., Yoshimura, A.: "The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2."J. Biol. Chem.. 276. 12530-12538 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kawashima, T., Murata, K., Akira, S., Tonozuka, Y., Minoshima, Y., Feng, S., Kumagai, H., Tsuruga, H., Ikeda, Y., Asano, S., Nosaka, T., Kitamura, T.: "STAT5 induces macrophage differentiation of Ml leukemia cells through activation of IL-6 production mediated by NF-kB p65."J. Immunol.. 167. 3652-3660 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tonozuka, Y., Fujio, K., Sugiyama, T., Nosaka, T., Hirai, M., Kitamura, T.: "Molecular cloning of a human novel type I cytokine receptor related to Deltal."Cytogenetics and Cell Genetics. 93. 23-25 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ishido, M., Yamamoto, A., Kitamura, T., Nagayama, K., Ohashi, M.: "Cholesterol requirement for receptor transport from multivesicular late endosomes to the Golgi."J.Cell. Science. 114. 1965-1976 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tulin, E.E., Onoda, N., Macda, M., Hasegawa, M., Nosaka, T., Nomura, H., Asano, S., Kitamura, T.: "A novel secreted form of immune suppressor factor with high homology to vacuolar ATPase identified by forward genetic approach of functional screening based on cell proliferation."J. Biol. Chem.. 276. 27519-27526 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kimura, M., Koseki, Y., Yamashita, M., Watanabe, N., Shimizu, C., Katsumoto, T., Kitamura, T., Taniguchi, M., Koseki, H., Nakayama, K.: "Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene."Immunity. 15. 275-287 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Senga, T., Iwamoto, T., Kitamura, T., Miyake, Y., Hamaguchi, M.: "JAK/Stat3 dependent activation of RalGDS/Ral pathway in Ml mouse myeloid leukemic cells."J. Biol. Chem.. 276. 32678-32681 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Frasor, J., Park, K-S., Byers, M., Telleria, C., Kitamura, T., Yu-Lee, L., Djiane, J., Park-Sarge, 0.-K., Gibori, G.: "Differential roles for Stat5 α and Statβ in prolactin stimulation of estrogen receptor a and b transcription."Molecular Endcrinol.. 15. 2172-2181 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, S., Yamamoto, N., Kitamura, T., Nakamura, K., Nakafuku, M.: "Proleferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord."Exp. Neurol.. 172. 115-127 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tokoro, Y., Shibuya, K., Osawa, M., Tahara-Hanaoka, S., Iwama, A., Kitamura, T., Nakauchi, H., Shibuya, A.: "Molecular cloning and characterization of mouse tspan-3, a novel member of the tetraspanin superfamily, expressed on resting dendritic cells."Biochem. Biophys. Res. Commun.. 288. 178-183 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamashita, Y., Kaijigaya, S., Yoshida, K, Ueno, S., Ota, J., Ohmine, K., Ueda, M., Miyazato, A., Ohya, K., Kitamura, T., Ozawa, K., Mano, H.: "Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase."J. Biol. Chem.. 276. 39012-39020 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueno, M., Igarashi, K., Kimura, N., Okita, K., Takizawa, M., Nobuhisa, I., Kojima, T., Kitamura, T., Morgan, S.M., Shiomura, T., Suda, T., Nakashima, K., Taga, T.: "Identification of an embryonic dorsal aorta specific gene, endomucin, and its inhibitory activity on cell adhesion."Biochem. Byophys. Res. Commun.. 287. 501-506 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ye, S.K., Agata, Y., Lee, H.C., Kurooka, H., Kitamura, T., Shimizu, A., Honjo, T., Ikuta, K.: "The IL-7 receptor controls the accessbility of the TCR γ locus by Stat5 and histone acetylation."Immunity. 15. 813-823 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, S., Nagao, M., Kitamura, T., Nakatomi, H., Sugimori, M., Kosako, H., Yamamoto, N., Takebayashi, H., Weinmaster, G., Nakamura, K., Nakafuku, M.: "Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord."J.Neurosci.. 21. 9814-9823 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Arakawa, M., Nakayama, Y., Hara, T., Shiozuka, M., Takeda, S., Kaga, K., Kondo, S., Morita, S., Kitamura, T., Matsuda, R.: "Negamycin can restore dystrophin in mdx skeletal muscle."Acta Myologica. 20. 154-158 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitamura, T., Kawashima, T., Minoshima, Y., Tonozuka, Y., Hirose, K., Nosaka, T.: "Role of MgcRacGAP/CYK4 as a regulator of small GTPase Rho family in cytokinesis and cell differentiation."Cell Structure and Function. 26. 645-651 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tulin, E.E., Onoda, N., Hasegawa, M., Nosaka, T., Nomura, H., Kitamura, T.: "Genetic approach and phenotype-based complementation screening for identification of stromal cell-derived proteins involved in cell proliferation."Exp. Cell Res.. 272. 23-31 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tulin, E.E., Onoda, N., Hasegawa, M., Nomura, H., Kitamura, T.: "Inhibition of human endothelial cell proliferation by ShIF, a vacuolar H+-ATPAse-like protein."Oncogene. 21. 844-848 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sai, X., Kawamura, Y., Kokame, K., Yamaguchi, H., Shiraishi, H., Suzuki, R., Suzuki, T., Kawaichi, M., Miyata, T., Kitamura, T., De Strooper, B., Yanagisawa, K., Komano, H.: "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein."J. Biol. Chem.. 277. 12915-12920 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nosaka, T., Kitamura, T.: "Pim-1 expression is sufficient to induce cytokine independence in murin hematopoietic cells, but is dispensable for BCR-ABL-mediated transformation."Exp. Hematol.. 30. 697-702 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakamura, T., Ouchida, R., Kodarna, T., Kawashima, T., Watanabe, S., Morimoto, C., Kitamura, T., Tanaka, H.: "Cytokine receptor common β subunit-mediated STAT5 activation confers NFκB activation in murinepro B cell line Ba/F3 cells."J. Biol. Chem.. 277. 6254-6265 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Perez, 0.D., Kinoshita, S., Hitoshi, Y., Payan, D.G., Kitamura, T., Nolan, G.P., Lorens, J.: "Activation of the PKB/AKT pathway by ICAM-2."Immunity. 16. 51-65 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nagai, Y., Akashi, S., Nagafuku, M., Ogata, M., Iwakura, Y., Akira, S., Kitamura, T., Kosugi, A., Kimoto, M., Miyake, K.: "Essential role of MD-2 in LPS responsiveness and TLR4 distribution."Nat. Immunol.. 3. 667-672 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Gugasyan, R., Quilici, C., I, S.T., Grail, D., Verhagen, A.M., Roberts, A., Kitamura, T., Dunn, A.R., Lock, P.: "Dok-related protein negatively regulates T cell development ts RasGTPase activating protein and Nck docking sites."J. Cell Biol.. 158. 115-125 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Stoeclin, G., Colombi, M., Raineri, I., Leuenberger, S., Mallaun, M., Schmidlin, M., Gross, B., Lu, M., Kitamura, T., Moroni, C.: "Functional cloning of BRF-1, a regulator of ARE-dependent mRNA turnover."EMBO J.. 21. 4709-4718 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Komano, H., Kawamura, Y., Shiraishi, H., Sai, X., Suzuki, R., Kawaichi, M., Kitamura, T., Yanagisawa, K.: "A new functional screening system for the identification of DNA encoding a regulator of γ-cleavage."J. Biol. Chem.. 277. 39627-39633 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ezoe, S., Matsumira, I., Ishihara, K., Minegishi, N., Takahashi, S., Mchii, T., Kitamura, T., Yamamoto, M., Enver, T., Kanakura, Y.: "GATA-2 affects cytokine-dependent growth of hematopojetic cells through accumulation of p21 WAF1 and p27Kipl proteins."Blood. 100. 3512-3520 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yujiri, T., Nawata, R., Takahashi, T., Sato, Y., Tanizawa, Y., kitamura, T., Oka, Y.: "MEK kinase I interacts with focal adhesion kinase and regulates insulin receptor substrate-l expression."J. Biol. Chem.. 278. 3846-3851 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ozawa, T., Sako, Y., Sato, M., Kitamura, T., Umezawa, Y.: "A genetic approach to identifying mitochondrial proteins."Nat. Biotechnol.. 21. 287-293 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Minoshima, Y., Kawashima, T., Hirose, K., Tonozuka, Y., Kawajiri, A., Bao, Y-C., Deng, X., Tatsuka, M., Narumiya, S., May, W.S.Jr., Nosaka, T., Semba, K., Inoue, T., Satoh, T., Inagaki, M., Kitamura, T.: "Phosphorylation by Aurora B converts MgcRacGAP to a RhoGAP during cytokinesis."Dev. Cell. 4. 549-560 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nosaka, T., Morita, S., Kitamura, H., Nakajima, H., Shibata, F., Morikawa, Y., Kataoka, Y., Ebihara, Y., Kawashima, T., Itoh, T., Ozaki, K., Senba, B., Tsuji, K., Makishima, F., Yoshida, N., Kitamura, T.: "Mammalian twisted gastulation is essential for skeleto-lymphogenesis."Mol. Cell. Biol.. 23. 2969-2980 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kitamura, T., Koshino, Y., Shibata, F., Nakajima, H., Nosaka, T., Kumagai, H.: "Retrovirus-mediated gene transfer and expression cloning, powerful tools in functional genomics."Exp. Hematol.. 31. 1007-1014 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Bao, Y-C., Tsuruga, H., Hirai, M., Kitamura, T., Kumagai, H.: "Identification of a human cDNA sequence which encodes a novel membrane-associated protein containing a zinc metalloprotease motif."DNA Research. 10. 123-128 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murata, K., Kumagai, H., Kawashima, T., Irie, M., Nakajima, H., Tamitsu, K., Nosaka, T., Asano, S., Kitamura, T.: "A novel tyrosine kinase inhibitor GTP14564 specifically inhibits constitutively active fms-like tyrosine kinase 3 through inactivation of STAT5."J. Biol, Chem.. 278. 32892-32898 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ueno, H., Sakita-Ishikawa, M., Morikawa, Y., Nakano, T., Kitamura, T., Saito, M.: "A stromal cell-derived membrane protein that supports hematopoietic stem cells."Nat. Immunol.. 4. 457-463 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Hisaoka, T., Morikawa, Y., Kitamura, T., Semba, E.: "Expression of a member of tumor necrosis factor receptor superfamily, TROY, in the developing and the adult mouse brain."Brain Research. 143. 105-109 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Takizawa, M., Nobuhisa, I., Igarashi, K., Ueno, M., Nakashima, K., Kitamura, T., Taga, T.: "Requirement of gp130 signaling for the AGM hematopolesis."Exp. Hematol.. 31. 283-289 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tahara, H., Fujio, K., Araki, Y., Setoguchi, K., Misaki, Y., Kitamura, T., Yamamoto, K.: "Reconstitution of CD8+ T cells by retroviral transfer of the T-cell receptor ab chain genes isolated from a clonally expanded P815 infiltrating lymphocytes."J. Immunol.. 171. 2154-2160 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kumagai, H., Oki, T., Tamitsu, K., Feng, S-Z., Ono, M., Nakajima, H., Bao, Y-C., Kawakami, Y., Nagayoshi, K., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Kawakami, T., Kitamura, T.: "Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells."Biochem. nyophys. Res. Commun.. 307. 719-729 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Murata, K., Kumagai, H., Kawashima, T., Tamistu, K, Irie, M., Nakajima, H., Suzu, S., Shibuya, M., Kamihara, S., Nosaka, T., Asano, S., Kitamura, T.: "Selective Cytotoxic Mechanism of GTP-14564, a Novel Tyrosine Kinase Inhibitor in Leukemia Cells Expressing a Constitutively Active Fins-like Tyrosine Kinase 3 (FLT3)."J. Biol. Chem.. 278. 32892-32898 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishlyama, C., Nishlyama, M., Ito, T., Masaki, S., Masuoka, N., Yamane, H., Kitamura, T., Ogawa, H., Okumura, K.: "Functional analysis of PU.1 domains in monocyte-specific gene regulation."FEBS letters. 561. 63-68 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishiyama, C., Nishiyama, M., Ito, T., Masaki, S., Maeda, K., Masuoka, N., Yamane, H., Kitamura, T., Ogawa, H., Okumura, K.: "Overproduction of PU.1 in mast cell progenitors: its effect on monocyte-and mast cell-specific gene expression."Biochem. Biophys. Res. Commun.. 313. 516-521 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ikeda, Y., Imai, Y., Kumagai, H., Nosaka, T., Morikawa, Y., Hisaoka, T., Manabe, I., Maemura, K., Nakaoka, T., Imamura, T., Miyazono, K., Komuro, I., Nagai, R., Kitamura, T.: "Vasorin, a novel TGF-β binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo."Proc. Nati. Acad. Sci. USA. (in press.). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishizawa, H., Matsuda, M., Yamada, Y., Kawai, K., Suzuki, B., Makishima, M., Kitamura, T., Shimomura, I.: "Musculin, a novel skeletal mescie-derived secretary factor."J. Biol. Chen. (in press.). (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yujiri, T.: "MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor Substrate-1 expression."The Journal of Biological Chemistry. 278. 3846-3851 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ozawa, T.: "A genetic approach to identifying mitochondrial proteins."Nature Biotechnology. 21. 287-293 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Minoshima, Y.: "Phosphorylation by Aurora B converts MgcRacGAP to a RhoGAP during cytokinesis."Developmental Cell. 4. 549-560 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nosaka, T.: "Mammalian twisted gastulation is essential for skeleto-lymphogenesis."Molecular and Cellular Biology. 23. 2969-2980 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kitamura, T.: "Retrovirus-mediated gene transfer and expression cloning, powerful tools in functional genomics."Experimental Hematology. 31. 1007-1014 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Bao, Y-C.: "Identification of a human cDNA sequence which encodes a novel membrane-associated protein containing a zinc metalloprotease motif."DNA Research. 10. 123-128 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Murata, K.: "A novel tyrosine kinase inhibitor GTP14564 specifically inhibits constitutively active fins-like tyrosine kinase 3 through inactivation of STAT5."The Journal of Biological Chemistry. 278. 32892-32898 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ueno, H.: "A stromal cell-derived membrane protein that supports hematopoietic stem cells."Nature Immunology. 4. 457-463 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Hisaoka, T.: "Expression of a member of tumor necrosis factor receptor superfamily, TROY, in the developing and the adult mouse brain."Brain Research. 143. 105-109 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Takizawa, M.: "Requirement of gp130 signaling for the AGM hematopoiesis."Experimental Hematology. 31. 283-289 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tahara, H.: "Reconstitution of CD8+T cells by retroviral transfer of the T-cell receptor ab chain genes isolated from a clonally expanded P815 infiltrating lymphocytes."The Journal of Immunology. 171. 2154-2160 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kumagai, H.: "Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells."Biochemical and Biophysical Research Communications. 307. 719-729 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tulin, E.E.: "Genetic approach and phenotype-based complementation screening for identification of stromal cell-derived proteins involved in cell proliferation"Exp. Cell Res.. 272. 23-31 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Tulin, E.E.: "Inhibition of human endothelial cell proliferation by ShIF, a vacuolar H^+-ATPAse-like protein"Oncogene. 21. 844-848 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nosaka, T.: "Pim-1 expression is sufficient to induce cytokine independence in murin hematopoietic cells but is dispensable for BCR-ABL-mediated transformation"Exp.Hematol.. 30. 697-702 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Perez, O.D.: "Activation of the PKB/AKT pathway by ICAM-2"Immunity. 16. 51-65 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nagai, Y.: "Essential role of MD-2 in LPS responsiveness and TLR4 distribution"Nat.Immunol.. 3. 667-672 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Gugasyan, R.: "Dok-related protein negatively regulates T cell development ts RasGTPase activating protein and Nck docking sites"J. Cell Biol.. 158. 115-125 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Stoeclin, G.: "Functional cloning of BRF-1, a regulator of ARE-dependent mRNA turnover"EMBO J.. 21. 4709-4718 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Komano, H.: "A new functional screening system for the identification of DNA encoding a regulator of γ-cleavage"J.Biol.Chem.. 277. 39627-39633 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Ezoe, S.: "GATA-2 affects cytokine-dependent growth of hematopoietic cells through accumulation of p21^<WAF1> and p27^<Kip1> proteins"Blood. 100. 3512-3520 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yujiri, T.: "MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression"J.Biol.Chem.. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Minoshima, Y.: "Aurora B Phosphorylates MgcRacGAP and Induces RhoGAP Activity during M Phase Identification of a RhoGAP Indispensable for Cytokinesis"Developmental Cell. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nosaka, T.: "Dwarfism and lymphoid deficiency in mice lacking twisted gastrulation"Mol.Cell.Biol.. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kitamura, T.: "Retrovirus-mediated gene transfer and expression cloning, powerful tools in functional genomics"Exp.Hematol.. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kagami, S.: "Role of Stat5a in T Helper Cell Differentiation"Blood. 97. 2358-2365 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hirose, K.: "MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody"J. Biol. Chem.. 276. 5821-5828 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kamizono, S.: "The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2"J. Biol. Chem.. 276. 12530-12538 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kawashima, T: "STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-κB p65"J. Immunol.. 167. 3652-3660 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tonozuka, Y.: "Molecular cloning of a human novel type I cytokine receptor related to Delta1"Cytogeneties and Cell Genetics. 93. 23-25 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ishido, M.: "Cholesterol requirement for receptor transport from multivesicular late endosomes to the Golgi"J. Cell Science. 114. 1965-1976 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tulin, E.E.: "A novel secreted form of immune suppressor factor with high homology to vacuolar ATPase identified by forward genetic approach of functional screening based on cell proliferation"J. Biol. Chem.. 276. 27519-27526 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kimura, M.: "Regulation of Th2 cell diffrentiation by mel-18, a mammalian polycomb group gene"Immunity. 15. 275-287 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Senga, T.: "JAK/Stat3 dependent activation of RalGDS/Ral pathway in M1 mouse myeloid leukemic cells"J. Biol. Chem.. 276. 32678-32681 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Frasor, J.: "Differential roles for Stat5α and Stat5β in prolactin stimulation of estrogen receptor a and b transcription"Molecular Endcrinol. 15. 2172-2181 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamamoto, S.: "Proleferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord"Exp. Neurol.. 172. 115-127 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tokoro, Y.: "Molecular cloning and charcterization of mouse tspan-3, a novel member of the tetraspanin superfamily, expressed on resting dendritic cells"Biochem. Biophys. Res. Commun.. 288. 178-183 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamashita, Y.: "Sak serine-threonine kinase acts as an effector of Tec tyrosine kinase"J.Biol.Chem.. 276. 39012-39020 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ueno, M.: "Identification of an embryonic dorsal aorta specific gene, endomucin, and its inhibitory activity on cell adhesion"Biochem. Biopbys. Res. Commun.. 287. 501-506 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ye, S.K.: "The IL-7 receptor controls the accessbility of the TCRγ locus by Stat5 and histone acetylation"Immunity. 15. 813-823 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamamoto, S.: "Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord"J.Neurosci.. 21. 99814-9823 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tulin, E. E.: "SF20, a novel bone marrow stroma-derived factor that binds to mouse TSA-1 and supports lymphoid cell proliferation"J.Immunol.. 167. 6338-6347 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Arakawa, M.: "Negamycin can restore dystrophin in mdx sskeletal muscle"Acta Myologica. 20. 154-158 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tulin, E.E.: "Gnetic approach and phenotype-based complementation screening for identification of stromal cell-derived proteins involved in cell proliferation"Exp.Cell Res.. 272. 23-31 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tulin, E.E.: "Inhibition of human endothelial cell proliferation by ShIR, a vacuolar H+-ATPAse-like protein"Oncogene. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakamura, T.: "Cytokine receptor common β subunit-mediated STAT5 a activation confers NFκB activation through IkB-independent mechanism in a murine pro B cell line Ba/F3"J. Biol. Chem.. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Kitamura, T.: "Role of MgcRacGAP/CYK4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation"Cell Structure and Function. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Perez, O.D.: "Acitivation of the PKB/AKT pathway by ICAM-2"Immunity. 16. 51-65 (2002)

    • Related Report
      2001 Annual Research Report

URL: 

Published: 2001-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi