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Identification and regulation of differentiation In bone marrow -derived vascular progenitor cells

Research Project

Project/Area Number 13557061
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Circulatory organs internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

HIRATA Yasunobu  The University or Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (70167609)

Co-Investigator(Kenkyū-buntansha) SATA Masataka  The University or Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (80345214)
SUZUKI Etsu  The University or Tokyo, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 (40313134)
Project Period (FY) 2001 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥11,600,000 (Direct Cost: ¥11,600,000)
Fiscal Year 2003: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2002: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2001: ¥9,000,000 (Direct Cost: ¥9,000,000)
Keywordsneointima / arteriosclerosis / stem cell / bone marrow / VSMC / LacZ / 成体幹細胞 / 新生内膜I / 欠陥平滑筋 / LacZ
Research Abstract

We have suggested that bone marrow-derived progenitor cells may contribute to the pathogenesis of vascular diseases. On the other hand, It was reported that bone marrow cells do not participate substantially in vascular remodeling in other experimental systems. in this study, three distinct types of mechanical vascular injuries were induced in the same mouse whose bone marrow had been reconstituted with that of GFP or LacZ mice. All injuries are known to cause smooth muscle cell (SMC) hyperplasia. At 4 weeks after wire-mediated endovascular injury, a significant number of the neointlmal and medial cells derived from bone marrow. In contrast, marker-positive cells were seldom detected in the lesion induced by perivascular cuff replacement. There were only a few bone marrow-derived cells in the neointima after ligation of the common carotid artery. These results indicate that the origin of Intimal cells is diverse and that contribution of bone marrow-derived cells to neointlmal hyperpiasia depends on the type of model.

Report

(4 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] Sata M, Sugawara S, Yoshizumi M, Ouchi Y, Hirata Y, Nagai R: "Acute and chronic smooth muscle ell apoptosis after mechanical vascular injury can occur independently of the fas-death pathway."Arterioscler Thromb Vasc Biol. 21. 1733-1737 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishimatsu H, Hirata Y 他: "Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury : studies on transgenic/knockout mice of adrenomedullin gene."Circ Res. 90. 657-663 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sata M, Hirata Y 他: "Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis."Nat Med. 29. 403-409 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki E, Nishimatsu H, Satonaka H, Walsh K, Goto A, Omata M, Fujita T, Nagai R, Hiiata Y: "Angiotensin II induces myocyte enhances factor 2- and calcineurin/ nuclear factor of activated T cell-dependent transcriptional activation in vascular myocytes."Circ Res. 90. 1004-1011 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shindo T, Manabe I, Maemura K, Sata M, Hirata Y, Kadowaki T, Nagai R, etc.: "Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling."Nat Med. 8. 856-863 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Abe M, Sata M, Nishimatsu H, Nagata D, Suzuki E, Terauchi Y, Kadowaki T, Matsuo H, Hirata Y, Nagai R: "Adrenomedullin augments collateral development in response to acute ischemia."Biochem Biophys Res Commun. 306. 10-15 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sata M, Tanaha K, Ishizaha N, Hirata Y, Nagai R: "Absence of p53 leads to accelerated neointimal hyperplasia after vascuhir injury."Arterioscler Thromb Vase Biol. 23. 1548-1552 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tnaka K, Hirata Y 他: "Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries."Clrc Res. 93. 783-790 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Satonaka H, Hirata Y 他: "Calcineurin promotes the expression of monocyte chemoattractant protein-1 in vascular myocytes and mediates vascular inflammation."Circ Res. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Niu P, Hirata Y 他: "Protective Effects of Endogenous Adrenomedullin on Cardiac Hypertrophy, Fibrosis, and Renal Damage."Circulation. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sata M, Sugiura S, Yoshlzumi M, Ouchi Y, Hirata Y, Nagal R: "Acute and chronic smooth muscle cell apoptosls after mechanical vascular injury can occur independently of the fas-death pathway."Arterioscier Thromb Vasc Biol. 21. 1733-1737 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Kakoki M, Nagata D, Hayakawa H, Satonaka H, Sata M, Tojo A, Suzuki E, Kangawa K, Matsuo H, Kitamura T, Nagai R: "Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury : studies on transgenic/knockout mice of adrenomedullin gene."Circ Res. 90. 657-663 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sata M, Saiura A, Kunisato A, Tojo A, Okada S, Tokuhisa T, Hirai H, Mauuchi M, Hirata Y, Nagai R: "Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis."Nat Med. 8. 403-409 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Suzuki E, Nishimatsu H, Satonaka H, Walsh K, Goto A, Omata M, Fujita T, Nagai R, Hirata Y: "Anglotensin II Induces myocyte enhancer factor 2-and calcineurin/nuclear factor of activated T cell-dependent transcriptional activation in vascular myocytes."Circ Res. 90. 1004-1011 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S.Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Ishikawa T, Suzuki T, Morita H, Maemura K, Sota M, Hirata Y, Komukai M, Kagechika H, Kadowaki T, Kuraboyashi M, Nagai R: "Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling."Nat Med. 8. 856-863 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Abe M, Sata M, Nishimatsu H, Nagata D, Suzuki E, Terauchi Y, Kadowaki T, Minamino N, Kangawa K, Matsuo H, Hirata Y, Nagai R: "Adrenomedullin augments collateral development in response to acute ischemia.."Biochem Biophys Res Commun. 306. 10-15 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Sata M, Tanaka K, Ishizaka N, Hirata Y, Nagai R: "Absence of p53 leads to accelerated neointimal hyperplasia after vascular injury."arterioscler Thromb Vasc Biol. 23. 1548-1552 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tnaka K, Sata M, Hirata Y, Nagai R: "Diverse contribution of bone morrow cells to neointimd hyperplasia after mechanical vascular injuries."Circ Res. 93. 783-790 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Satonaka H, Suzuki E, Nishimatsu H, Takeda R, Goto A, Fujita T, Nagai R, Hirata Y: "Calcineurin promote the expression of monocyte chemoattractant protein-1 in vascular myocytestes and mediates vascular inflammation."Circ Res. (In press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Niu P.Shindo T, Iwata H, limuro S, Tckeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K, Hirata Y, Nagai R: "Protective Effects of Endogenous Adrenomedullin on Cardiac Hypertrophy, Fibrosis, and Renal Damage."Circulation. (In press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Satonaka H, Hirata Y 他: "Calcineurin promotes the expression of monocyte chemoattractant protein-1 in vascular myocytes and mediates vascular inflammation."Circ Res. (in press). (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Tanaka K, Hirata Y 他: "Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries."Circ Res. 93. 783-790 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sata, M, Hirata, Y 他: "A bsence of p53 leads to accelerated neointimal hyperplasia after vascular injury."Arterioscier.Thromb.Vasc.Biol. 23. 1548-0552 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nishimatsu H, Hirata Y 他: "Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice."Hypertens Res. 26 Suppl. S79-S84 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Abe M, Hirata Y 他: "Adrenomedullin augments collateral development in response to acute ischemia."Biochem Biophys Res Commun. 306. 10-15 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fukino K, Hirata Y 他: "Genetic background influences therapeutic effectiveness of VEGF."Biochem Biophys Res Commun. 310. 143-147 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sata M, Hirata Y. et al.: "Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis"Nature Med.. 8. 403-409 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suzuki E, Hirata Y. et al.: "Angiotensin II induces myocyte enhancer factor 2-and calcineurin/nuclear factor of activated T cell-dependent transcriptional activation in vascular myocytes"Circ.Res.. 90. 1004-1011 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nishimatsu H, Hirata Y. et al.: "Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury : studies on transgenic/knockout mice of adrenomedullin gene"Circ.Res.. 90. 657-663 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shindo T, Hirata Y. et al.: "Kruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling"Nature Med.. 8. 856-863 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sata M, Hirata Y. et al.: "Mouse genetic evidence that tranilast reduces smooth muscle cell hyperplasia via a p21(WAF1)-dependent pathway"Arterioscler Thromb Vasc. Biol.. 22. 1305-1309 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suzuki N, Hirata Y. et al.: "Orthogonality of calcium concentration and ability of 4,5-diaminofluorescein (DAF-2) to detect NO"J.Biol.Chem.. 277. 47-49 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nagata D, Hirata Y, et al.: "Transcriptional activation of the cyclin D1 gene is mediated by multiple cis elements including SP1 sites and a cyclic AMP responsive element in vascular endothelial cells"J Biol Chem. 276. 662-669 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Wang Y, Hirata Y, et al.: "Crucial Role of Type 1, but Not Type 3, Inositol 1, 4, 5-Trisphosphate(IP3)Receptors in IP3-Induced Ca2+ Release, Capacitative Ca2+ Entry, and Proliferation of A7r5 Vascular Smooth Muscle Cells"Circ Res. 88. 202-209 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kojima H, Hirata Y, et al.: "Bioimaging of nitric oxide with fluorescent indicators based on rhodamine chromophore"Anal Chem. 73. 1967-1973 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Saiura A, Hirata Y, et al.: "Circulating smooth muscle progenitor cells contribute to atherosclerosis"Nature Med. 7. 382-383 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sata M, Hirata Y, et al.: "Acute and chronic smooth muscle cell apoptosis after mechanical vascular injury can occur independently of the fas-death pahtway"Arterioscler Thromb Vasc Biol. 21. 1733-1737 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Saiura A, Hirata Y, et al.: "Tranilast inhibits transplant-associated coronary arteriosclerosis in a murine model of cardiac transplantation"Eur J Pharmacol. 433. 163-168 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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