| Project/Area Number |
13557074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
TATSUO Ido Tohoku University Cyclotron radioisotope Center, Professor, サイクロトロン・ラジオアイソトープセンター, 教授 (80134063)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Masatoshi Tohoku University Cyclotron Radioisotope Center, Professor, サイクロトロン・ラジオアイソトープセンター, 教授 (00125501)
IWATA Ren Tohoku University Cyclotron Radioisotope Center, Professor, サイクロトロン・ラジオアイソトープセンター, 教授 (60143038)
IMAHORI Yoshio Kyoto Universty of Medicine, Department of Neurosurgery. Associate Professor, 医学部, 助教授 (80191899)
KAGAYA Yutaka Tohoku University Graduate School of Medicine, Department of Cardiovascular Medicine, Associate Researcher, 医学部, 助手 (90250779)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥13,600,000 (Direct Cost: ¥13,600,000)
Fiscal Year 2002: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 2001: ¥8,500,000 (Direct Cost: ¥8,500,000)
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| Keywords | Positron Emission tomography / Radio laveled diacylglycerol / Brain Function / Tumor diagnosis / PLC activity / PLD activity / Myocardial remodeling / Recovery of injury / PLG活性評価 |
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| Research Abstract |
Clinical applications of second messenger imaging by PET has been demonstrated in the fields of brain function study, myocardial remodeling and tumor diagnosis. Basic study of cell culture and animal model made clear that the imaging by ^<11>C-labeled 1,2-diacylglycerol ([^<11>C]DAG) response to PLC activity and ^<18>F-labeled 1,2-diacylglycerol ([^<18>F]FDAG) response to PLD activity. [^<11>C]DAG is used as potential imaging tracers for postsynaptic biological responses in human brain of healthy normal subjects and with various diseases such as stroke, Parkinson's and Alzheimer's disease. The [^<11>C]DAG study in myocardial infarction(MI) suggested that this technology may be useful for visually detecting regions with activated PI metabolism in the process of ventricular remodeling after MI.
[^<18>F]FDAG applied to tumor detection based on the response to PLD activity in cultured cell, tumor tissues and animal models and the results suggested that [^<18>F]FDAG are used as potential imaging tracers for early stage of tumor growth.
The simplified PET-MR fusion imaging computer program has been developed to promote clinical application of kinetic analysis.
This technology for medical imaging of second messenger systems will be new frontier in various fields of rmedical diagnosis.
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