TANIGAWA Noboru Kansai Medical University Faculty of Medicine Assistant Professor, 医学部, 講師 (90227215)
KAWA Ha sk Kansai Medical University Faculty of Medicine Associate Professor, 医学部, 助教授 (30152896)
HARIMA Yoko Kansai Medical University Faculty of Medicine Associate Professor, 医学部, 助教授 (80140276)
OKUDA Yoshikazu Kansai Medical University Faculty of Medicine Instructor, 医学部, 助手 (90252866)
|Budget Amount *help
¥9,600,000 (Direct Cost: ¥9,600,000)
Fiscal Year 2002: ¥4,600,000 (Direct Cost: ¥4,600,000)
Fiscal Year 2001: ¥5,000,000 (Direct Cost: ¥5,000,000)
To evaluate the feasibility of a new liquid embolic material, 'Onyx', for treating liver tumor.
Material and Methods:
'Onyx' is a mixture of 6%(w/v) ethylene-vinyl alcohol polymer dissolved in anhydrous dimethyl sulfoxide (DMSO) with 28%(w/v) tantalum powder. In addition to 6% Onyx, we also tried 4%, 2% and 1% solutions, prepared by adjusting the amount of DMSO. We used 15 white rabbits with liver tumors created by percutaneous injection of VX2 tumor cells. In 4 groups with 3 rabbits in each, the liver arteries were embolized with 6%, 4%, 2% and 1% Onyx, respectively, and in 3 rabbits DMSO alone was injected. The injections were performed just proximal to the bifurcation of the proper hepatic artery, followed by celiac arteriography. Post mortem, the livers were examined by soft tissue radiography, and liver-tissue sections microscopically.
The maximum number of arterial branching points passed by embolic material in either right or left hepatic arteries was 11, 15 and 16, for 6%, 4% and 2% Onyx, respectively, but was non-measurable for 1% Onyx. Minimum diameters of arteries reached by 6%, 4%, 2% and 1% Onyx in tumorous areas were 40μm, 35μm, 20μm and 10μm, respectively, and in non-tumorous areas 35μm, 5μm, 5μm and 5μm, respectively.
This study suggests that Onyx may be feasible for treatment of hepatic tumors.