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Investigation of traumatic brain injury mechanism: The role of shock wave aid "lens effect" of the sk*

Research Project

Project/Area Number 13557113
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field Cerebral neurosurgery
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

YOSHIMOTO Tkashi  Tohoku University, President, 総長 (50091765)

Co-Investigator(Kenkyū-buntansha) KUSAKA Yasuko  Tohoku University Hospital, Research Associate, 医学部附属病院, 助手 (00292219)
SAITO Tsutomu  Tohoku University, Institute of Fluid Science, Associate Professor, 流体科学研究所, 助教授 (00302224)
TAKAYAMA Kazuyoshi  Tohoku University, Institute of Fluid Science, Professor, 流体科学研究所, 教授 (40006193)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2002: ¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 2001: ¥7,100,000 (Direct Cost: ¥7,100,000)
KeywordsShock Wave / Traumatic Brain Injury / Diffuse Axonal Injury / Shearing Injury / Cavitation / High-Speed Photography / Holography / Concussion model / caviation / 高速度撮影装置 / 超高速度撮影装置
Research Abstract

Although various mechanism for traumatic brain injuries (TBI) have been proposed, much of them still hypothesis due to difficulties in elucidating their dynamic process. Therefore, we have investigated the mechanism of traumatic injury, especially the effect of shapes aid structure of skull, using the methodology of investigating shock waves, which is also a phenomena considered to be involved in the occurrence of TBI and accompanying much energy in very short period of time. The effect of shock wave on brain was also investigated in animal experiments.
Traumatic impact generated by bullet at 20 m/s was exposed on a cranium model made of acryl cylinder, 10% gelatin, teflon, water, which are mimicking skull, brain, dura, and CSF respectively, and the phenomenon within 1 ms after the impact was visualized by high-speed photography and holography. After the impact, two kinds of waves were observed (one starting from the margin toward center, and one starting at the impact point and propaga … More ting parallel toward the direction of impact). Although there needs modification in experimental set up to visualize covitation and morphological lens effect of the skull which might be involved for the occurrence of coup and contra-coup injury, we could observe the tendency for the second wave to generate injury.
For the investigation of shock wave-induced brain injury, we have produced compact type shock wave generator to expose limited area of brain on shock waves (under request for patent). Using it, pressure dependent TBI were investigated histologically. The pressure threshold for the brain damage was 1 MPa. Interestingly, when shock waves were exposed on brain via skull, the animal exhibited transient paresis, but showed no evidence of histological evaluation. Therefore, we have considered this as new concussion model. Using present shock wave source and by comparing the histology and electrophysiological findings of the animal model, the role of shock waves during TBI can be clarified in the future. Less

Report

(3 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • Research Products

    (42 results)

All Other

All Publications (42 results)

  • [Publications] Nakagawa A, Kusaka Y, Komatsu M, Hirano T, Sato M, Shirane R, Tkayama K, Yoshimoto T.: "Application of shock wave for cranioplasty. In vivo study on rat calvarium and basic study for irradiating shock wave on the brain"Acta Bioengineering Biomechanics. 4(suppl 1). 178-179 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirano T, Komatsu M, Uenohara H, Takahashi A, Takayama K, Yoshimoto T.: "A novel method of drug delivery for fibrinolysis with Ho : YAG laser-induced liquid jet"Laser Med Sci. 17. 165-172 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Hirano T, Kusaka Y, Sato M, Shirane R, Takayama K, Yoshimoto T.: "Biological effect of shock waves on rat brain : Pathological evaluation by compact Ho : YAG laser-induced cavitational shock wave generator"SPIE Proceedings. 4948. (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Hirano T, Kusaka Y, Sato M, Uenohara H, Shirane R, Takayama K, Yoshimoto T.: "Biological effect of shock waves : Pressure dependent pathological changes in the rat brain"Proceedings of IFMBE. 3(2). 984-985 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Kusaka Y, Hirano T, Saito T, Shirane R, Takayama K, Yoshimoto T.: "Application of low amplitude shock wave for cranioplasty : Experiment in the rat calvarium"Proceedings of IFMBE. 3(2). 1004-1005 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Kusaka Y, Hirano T, Sato M, Shirane R, Takayama K, Yoshimoto T.: "Experimental application of shock waves as treatment modality in the vicinity of brain and skull"J Neurosurg. July. 156-162 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Hirano T, Komatsu M, Sato M, Uenohara H, Ohyama H, Kusaka Y, Shirane R, Takayama K, Yoshimoto T.: "Ho: YAG laser-induced liquid jet knife: Possible novel method for dissection"Laser Surg Med. 31. 129-135 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 中川敦寛, 日下康子, 平野孝幸, 佐藤真理子, 斎藤務, 白根礼造, 高山和喜: "衝撃波を用いた頭蓋骨形成:衝撃波照射方法と安全性に関する検討"平成14年度衝撃波シンポジウム講演論文集. 413-416 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 中川敦寛, 日下康子, 平野孝幸, 佐藤真理子, 斎藤務, 白根礼造, 高山和喜: "衝撃波による圧依存性脳損傷に関する組織学的検討"平成14年度衝撃波シンポジウム講演論文集. 417-420 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 中川敦寛, 日下康子, 平野孝幸, 小松真, 佐藤真理子, 吉田貴之, 白根礼造, 高山和喜, 吉本高志: "衝撃波による骨形成誘導に関する基礎的研究"平成13年度衝撃波シンポジウム講演論文集. 705-708 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 中川敦寛, 平野孝幸, 日下康子, 佐藤真理子, 上之原広司, 白根礼造, 高山和喜, 吉本高志: "頭蓋近傍における衝撃波の医療応用に関する基礎実験"東北大学流体科学研究所第14回研発表会講演論文集. 90-93 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 小松 真 他: "細管から放出される衝撃波の伝播特性"平成13年度衝撃波シンポジウム講演論文集. 705-708 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 佐藤真理子, 平野孝幸, 中川敦寛, 上之原広司, 小松真, 高橋明, 吉本高志, 高山和喜: "Ho: YAGレーザー誘起液体ジェットに随伴する衝撃波"日本流体力学会年会2002講演論文集. 438-439 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 佐藤真理子, 平野孝幸, 中川敦寛, 上之原広司, 吉田康子, 白根礼造, 高山和喜, 吉本高志: "Ho: YAGレーザーの水中発振による脳組織への影響"日レ医誌(JJSLSM). 22. 219-219 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 佐藤真理子, 中川敦寛, 平野孝幸, 上之原広司, 白根礼造, 吉本高志, 高山和喜: "レーザー誘起水ジェットとその応用に関する研究"平成14年度衝撃波シンポジウム講演論文集. 341-342 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A., Kusaka Y, Komatsu M, Hirano T, Sato M, Shirane R, Takayama K, Yoshimoto T: "Application of shock wave for cranioplasty. In viva study on rat calvarium and basic study for irradiating shock wave on the brain."Acta Bioengineering Biomechanics. 4 suppl 1. 178-179 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hirano T, Komatsu M, Uenohara H, Takahashi A, Takayama K, Yoshimoto T: "A novel method of drug delivery for filxinolysis with Ho: YAG laser-induced liquid jet."Laser Med Sci. 17. 165-172 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Hirano T, Kusaka Y, Sato M, Shirane R, Takayama K, Yoshimoto T: "Biological effect of shock waves on rat brain: Pathological evaluation by compact Ha: YAG laser-induced cavitational shack wave generator."SPIE Proceeding. 4948. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Hirano T, Kusaka Y, Sato M, Uenohara H, Shirane R, Takayama K, Yoshimoto T: "Biological effect of shock waves: Pressure dependent pathological changes in the rat brain."Proceedings of IFMBE. 3(2). 984-985 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Kusaka Y, Hirano T, Sato M, Shirane R, Takayama K, Yoshimoto T: "Application of low amplitude shock wave for cranioplasty: Experiment in the rat colvarium."Proceedings of IFMBE. 3(2). 1004-1005 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Kusaka Y, Hirano T, Saito T, Shirane R, Takayama K, Yoshimoto T: "Experimental application of shock waves as treatment modality in the vicinity of brain and skull."J Neurosurg. 99. 156-162 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Hirano T, Komatsu M, Sato M, Uenohara H, Ohyama H, Kusaka Y, Shirane R, Takayama K, Yoshimoto T: "Ho: YAG laser-induced liquid jet knife: Possible novel method for dissection."Laser Surg Med. 31. 129-135 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Kusaka Y, Hirano T, Sato M, Saito T, Shirane R, Takayama K: "Cranioplasty using shock waves: Experiments on shock wave delivery and safety."Proceedings of Symposium on Shock Waves JAPAN 2003. 413-416 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Kusaka Y, Hirano T, Sato M, Saito T, Shirane R, Takayama K: "Histological evaluation of pressure-dependent shock wave-induced brain damage."Proceedings of Symposium on Shock Waves JAPAN 2003. 417-420 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Kusaka Y, Hirano T, Komatsu M, Sato M, Yoshida T, Shirane R, Takayama K, Yoshimoto T: "Application of shock wave for the treatment of skull defect: In vivo study in rat calvarium and basic study concerning safely for the brain"Proceedings of Symposium on Shock Waves JAPAN 2003. 705-708 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Hirano T, Kusaka Y, Sato M, Uenohara H, Shirane R, Takayama K, Yoshimoto T: "Application of shock waves is the vicinity of skull and brain: experiments conceming shock wave source and safety"Proceedings, Annual research meeting, Institute of Fluid Science, Tohoku University. 90-93 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Komatsu M, Hirano T, Nakagawa A, Sato M, Uenohara H, Yoshimoto T, Takayama K: "Characteristics of laser-induced shock waves released from a narrow tube."Proceedings of Symposium on Shock Waves JAPAN 2003. 705-708 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato M, Hirano T, Nakagawa A, Uenohara H, Komatsu M, Takahashi A, Yoshimoto T, Takayama K: "Medical application of shock waves caused by Ho: YAG laser-induced liquid jet."Proceedings, 2002 Meeting of Japan Society of Fluid Mechanics. 438-439 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A, Hirano T, Komatsu M, Uenohara H, Yoshida Y, Shirane R, Takayama K, Yoshimoto T: "Generation of shock waves after irradiation of laser within water."JJSLSM. 22. 219 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Sato M, Nakagawa A, Hirano T, Uenohara H, Shirane R, Yoshimoto T, Takayama K: "Study on laser-induced water jet and its application."Proceedings of Symposium on Shock Waves JAPAN 2003. 341-342 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Nakagawa A et al.: "Application of shock wave for cranioplasty. In vivo study on rat calvarium and basic study for irradiating shock wave on the brain"Acta of Bioengineering and Biomechanics. 4(suppl.1). 178-179 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakagawa A et al.: "Biological effect of shock waves : Pressure dependent pathological changes in the rat brain"Proceedings of 2nd European Medical & Biological Engineering Conference. 984-985 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakagawa A et al.: "Application of low amplitude shock wave for cranioplasty : Experiment in the rat calvarium"Proceedings of 2nd European Medical & Biological Engineering Conference. 1004-1005 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 小松真 他: "細管から放出される衝撃波の伝播特性"平成13年度衝撃波シンポジウム講演論文集. 689-692 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 中川敦寛 他: "衝撃波による骨形成誘導に関する基礎的研究"平成13年度衝撃波シンポジウム講演論文集. 705-708 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hirano T et al.: "Formation of a liquid jet by interaction between a laser-induced bubble and a shock wave"Lasers in Medical Science. 17. 165-172 (2002)

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      2002 Annual Research Report
  • [Publications] 高山和喜: "衝撃波医療"日本機会学会誌. 104・997. 814-815 (2001)

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      2001 Annual Research Report
  • [Publications] 高山和喜: "衝撃波の学際応用"日本機会学会論文集(B編). 67・657. 1-2 (2001)

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      2001 Annual Research Report
  • [Publications] 平野孝幸 他: "QスイッチパルスHo : YAGレーザー脳塞栓破砕術に関する基礎研究"第13回日本機械学会バイオエンジニアリング部門学術講演会講演論文集. 258-259 (2001)

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      2001 Annual Research Report
  • [Publications] 中川敦寛: "Ho : YAGレーザー水中発振による生体組織への影響"日本レーザー医学会誌. 22・3. 219 (2001)

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      2001 Annual Research Report
  • [Publications] Saito T, et al.: "Hazard predictions for volcanic explosions"Journal of volcanology and geothermal research. 106. 39-51 (2001)

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      2001 Annual Research Report
  • [Publications] Komatsu M, et al.: "Basic research on laser-induced shock/bubble interaction and water flow for medical application"Proceedings of 1st International Symposium on Advanced Fluid Information. 567-572 (2001)

    • Related Report
      2001 Annual Research Report

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Published: 2001-04-01   Modified: 2016-04-21  

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