| Project/Area Number |
13557135
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
KUMON Hiromi Okayama University Graduate School of Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授 (30144760)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOYAMA Teruhiko Okayama University Hospital, Assistant, 医学部附属病院, 助手 (40325113)
KAJIYA Fumihiko Okayama University Graduate School of Medicine and Dentistry, Professor, 大学院・医歯学総合研究科, 教授 (70029114)
NISHIGAKI Kazu Yuge National College of maritime technology Principal, 学校長 (40031447)
MATSUNAKA Toshiyuki Aloka Co.ltd, Division of TP technology, Manager, TP技術部, 部長(研究職)
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| Project Period (FY) |
2001 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 2002: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 2001: ¥4,600,000 (Direct Cost: ¥4,600,000)
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| Keywords | voiding disorder / urodynamic study / bladder outlet obstruction / benign prostatic hyperplasia / Doppler ultrasonography |
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| Research Abstract |
1. Flow velocity of urine can be measured by ultrasound sonography
It had been believed to be impossible to measure the intraurethral flow velocity by ultrasonography, since urine does not contain any particles reflecting ultrasound. We hypothesized that according to Bernoulli's principle a decrease of flow pressure caused by an accelerated urinary flow produces micro bubbles associated with cavitation responsible for Doppler signals. This hypothesis was confirmed by A simultaneous detection of microtubbles specific to cavitation with a charged-coupled device (CCD) camera and Doppler signals with an ultrasound scanner was conducted.
2. Velocity related parameters are proved to be useful for evaluating bladder outlet obstruction(BOO).
Functional cross-sectional area at prostatic urethra (UFA=UR/UV: UV: velocity at prostatic urethra, UR: flow rate) and velocity ratio (VR=V1/V2: V1: velocity at prostatic urethra, V2: velocity at sphincteric urethra) were proved to be practical parameters far evaluating BOO. "'e investigated the best flow velocity related parameter, which allowed prediction of improvement of lower urinary tract symptoms (LUTS) after α 1-blocker treatment.. The patients with higher V2 might be poor responders against alpha-blocker treatment.
3. Custom made software has been improved.
In order to reduce analytic time and apply the system not only for BOO but also for whole voiding dysfunction, analytic software has been improved.
(1) Automatic plotting of ROI (region of interest) ~
(2) Indication of corrected angle
(3) Automatic graphic indication of previously proposed parameters (Al, A2 and VR)
(4) Automatic graphic indication of new parameters to analyze bladder function
4. Velocity-flow plots.
Two dimensional graph plots between velocity related parameter and flow rate in whole voiding has been performed. A delay of initial velocity signal may be useful to diagnose voiding dysfunction
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