| Project/Area Number |
13557164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
補綴理工系歯学
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| Research Institution | NIIGATA UNIVERSITY |
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Principal Investigator |
UOSHIMA Katsumi NIIGATA UNIVERSITY, Medical and Dental Hospital, Professor, 医歯学総合病院, 教授 (50213400)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Akihiko NIIGATA UNIVERSITY, Medical and Dental Hospital, Lecturer, 医歯学総合病院, 講師 (20283020)
OKIJI Takashi NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合病院, 教授 (80204098)
NOMURA Syuuichi NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合病院, 教授 (40018859)
TAGAMI Junji Tokyo Medical and Dental University, Graduate School, Professor, 大学院・医歯学総合研究科, 教授 (50171567)
MIURA Hiroyuki Tokyo Medical and Dental University, Graduate School, Professor, 大学院・医歯学総合研究科, 教授 (40199956)
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| Project Period (FY) |
2001 – 2003
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| Project Status |
Completed (Fiscal Year 2003)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 2003: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 2002: ¥3,300,000 (Direct Cost: ¥3,300,000)
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| Keywords | non-metallic / patch test / proteomics / allergy / 抗原性 |
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| Research Abstract |
The purpose of this study was to establish non-metallic reagents of dental materials for patch tests and to investigate the biological responses against those antigens.
1.First, we tried to analyze the constituents of some specific dental materials. However, we failed to do so after 6 month or so. Because of the lack time, we decided to perform patch tests among allergic patients using "as is" dental materials such as cements and resins. 65 patients were tested with "as is" materials and 24 patients were tested with single reagents. 10 control non-allergic volunteers were tested with "as is" materials as well. As a result, there were significant numbers of patch test positives among the allergic patients and even a healthy volunteer showed severe positive a resin. We have to study these non-metallic dental material allergies from now on.
2.To study genetic differences between allergic patients and healthy individuals, we collected peripheral bloods out of 5 volunteers and proteomes were compared. As a result, we found approximately 10 putative proteins that might be playing some roles in the allergic reactions in the patients.
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